SPHEROID

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Fibrotic liver extracellular matrix induces cancerous phenotype in biomimetic micro-tissues of hepatocellular carcinoma model
《Hepatobiliary & Pancreatic Diseases International》2025年第1期92-103,共12页Kosar Nouri Abbas Piryaei Homeyra Seydi Ibrahim Zarkesh Ibrahim Ghoytasi Bahare Shokouhian Mustapha Najimi Massoud Vosough 
financially supported by grants from Royan In-stitute(grant No.400000200);Bahar Tashkhis Teb Co.(BTT,9703,9809,and 9903)。
Background: Despite considerable advancements in identifying factors contributing to the development of hepatocellular carcinoma(HCC), the pathogenesis of HCC remains unclear. In many cases, HCC is a consequence of pr...
关键词：Liver fibrosis Decellularized extracellular matrix SPHEROID Epithelial-to-mesenchymal transition Cell differentiation Hepatocellular carcinoma 
Three-dimensional models:from cell culture to Patient-Derived Organoid and its application to future liposarcoma research
《Oncology Research》2025年第1期1-13,共13页SAYUMI TAHARA SYDNEY RENTSCH FERNANDA COSTAS CASAL DE FARIA PATRICIA SARCHET ROMA KARNA FEDERICA CALORE RAPHAEL E.POLLOCK 
supported by DoD Grant W81XWH-22-1-0530.
Liposarcoma is one of the most common soft tissue sarcomas,however,its occurrence rate is still rare compared to other cancers.Due to its rarity,in vitro experiments are an essential approach to elucidate liposarcoma ...
关键词：Cell culture LIPOSARCOMA Patient-Derived Organoid(PDO) SPHEROID Three-dimensional(3D)cell culture 
Low-magnitude high-frequency vibration reduces prostate cancer growth and extravasation in vitro
《Mechanobiology in Medicine》2024年第4期83-96,共14页Amel Sassi Kimberly Seaman Xin Song Chun-Yu Lin Yu Sun Lidan You 
supported by the Natural Science and Engineering Research Council(NSERC,Grant No:06465-14).
Prostate cancer(PCa)continues to rank among the most common malignancies in Europe and North America with significant mortality rates despite advancements in detection and treatment.Physical activity is often recommen...
关键词：Low-magnitude high-frequency vibration Mechanical loading Vibration Prostate cancer Bone metastasis OSTEOCYTE Microfluidic SPHEROID 
Co-culture of natural killer cells and tumor spheroids on a heterogeneous multilayer paper stack
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第12期1097-1107,共11页Yuanyuan XIE Xiaoyan YANG Rong PAN Lixia GAO Ling YU 
supported by the National Natural Science Foundation of China(No.32171401);the Natural Science Foundation of Chongqing(Nos.CSTB2022NSCQ-MSX0808 and cstc2021jcyj-bsh0239);the Innovation Platform for Academicians of Hainan Province(No.YSPTZX202126),China。
Multilayer paper-based cell culture,as an in vitro three-dimensional(3D)cell culture method,has been frequently used to research drug bioavailability,therapeutic efficacy,and dose-limiting toxicity in malignant tumors...
关键词：Multilayer paper stack CO-CULTURE Tumor spheroid Human umbilical vein endothelial cell(HUVEC) Natural killer cell(NK cell) Migration 
Environmental genotoxicity assessment of nanoparticles using human airway epithelial model
《Emerging Contaminants》2024年第4期308-316,共9页Sirirak Hemmaphan Kotchapawn Somprasong Narisa K.Bordeerat 
supported by the Thailand Science Research and Innovation Fundamental Fund(TUFF 46/2565);by Thammasat University Research Fund(TUFT-FF 38/2565).
Because of the growing use of nanoparticles(NPs)in manufacturing consumer goods,it is essential to identify new in vitro approaches to assess their toxicity and improve risk assessment.Humans are exposed to NPs from c...
关键词：GENOTOXICITY NANOPARTICLES Human bronchial/tracheal epithelial cell 3D spheroid 
Framework nucleic Acid-MicroRNA mediated hepatic differentiation and functional hepatic spheroid development for treating acute liver failure
《Bioactive Materials》2024年第11期611-626,共16页Hongyan Wei Tiantian Xue Fenfang Li Enguo Ju Haixia Wang Mingqiang Li Yu Tao 
National Key Research and Development Program of China(2019YFA0111300);Thousand Talents Plan,the Guangdong Provincial Pearl River Talents Program(2019QN01Y131);Medical Science and Technology Research Fund of Guangdong Province(A2022112).
The specific induction of hepatic differentiation presents a significant challenge in developing alternative liver cell sources and viable strategies for clinical therapy of acute liver failure (ALF). The past decade ...
关键词：Hepatic differentiation Framework nucleic acid Functional hepatic spheroids Transcriptome sequencing analysis Acute liver failure therapy 
Spheroid construction strategies and application in 3D bioprinting
《Bio-Design and Manufacturing》2024年第5期800-818,共19页Chunxiang Lu Chuang Gao Hao Qiao Yi Zhang Huazhen Liu Aoxiang Jin Yuanyuan Liu 
supported by the National Natural Science Foundation of China(Nos.61973206,61703265,61803250,and 61933008);the Shanghai Science and Technology Committee Rising-Star Program(No.19QA1403700);the National Center for Translational Medicine(Shanghai)SHU Branch.
Tissue engineering has been striving toward designing and producing natural and functional human tissues.Cells are the fundamental building blocks of tissues.Compared with traditional two-dimensional cultured cells,ce...
关键词：SPHEROIDS STRATEGIES 3D bioprinting BIOFABRICATION 
Vascular units as advanced living materials for bottom-up engineering of perfusable 3D microvascular networks
《Bioactive Materials》2024年第8期499-511,共13页I.D.Orge H.Nogueira Pinto M.A.Silva S.J.Bidarra S.A.Ferreira I.Calejo R.Masereeuw S.M.Mihail C.C.Barrias 
developed under the scope of the EndoSWITCH project(PTDC/BTMORG/5154/2020);supported by the Portuguese Founda-tion for Science and Technology(FCT).The authors thanks FCT for Iasmim Orge’s PhD scholarship SFRH/BD/2020.07458;Sílvia Bidarra’s research contract DL 57/2016/CP1360/CT0006 and Silvia Ferreira’s research contract CEECINST/00132/2021/CP1774/CT0001;Iasmim Orge thanks the training provided under the scope of the REMODEL project(European Union’s Horizon 2020 research and innovation pro-gramme,grant agreement 7857491);The authors also acknowledge the support of i3S Scientific Platforms:“Bioimaging”member of the PPBI(Grant No:PPBI-POCI-01-0145-FEDER-022122);“Biointerfaces and Nanotechnology”(Grant No:UID/BIM/04293/2019);“BioSciences Screening”(member of the PT-OPENSCREEN(NORTE-01-0145-FEDER-085468);PPBI(PPBI-POCI-01-0145-FEDER-022122)).
The timely establishment of functional neo-vasculature is pivotal for successful tissue development and regen-eration,remaining a central challenge in tissue engineering.In this study,we present a novel(micro)vascular...
关键词：Engineered tissue Organ-on-chip Microtissue SPHEROID endothelial colony-forming cells 
Porous nanofibrous dressing enables mesenchymal stem cell spheroid formation and delivery to promote diabetic wound healing
《Chinese Journal of Chemical Engineering》2024年第4期156-164,共9页Kexin Zhang Wenmin Zhang Heng An Zhe Huang Yanzhen Wen Xiangyu Jiao Yongqiang Wen 
supported by Fundamental Research Program of Shanxi Province(202203021222199);the Taiyuan University of Science and Technology Scientific Research Initial Funding(20222090);the National Natural Science Foundation of China(21975019).
Delayed and nonhealing of diabetic wounds imposes substantial economic burdens and physical pain on patients.Mesenchymal stem cells(MSCs)promote diabetic wound healing.Particularly when MSCs aggregate into multicellul...
关键词：Electrospinning Homogenization Biomedical engineering Nanomaterials Stem cell spheroids Diabetic wound healing 
Improvement of histone deacetylase inhibitor efficacy by SN38 through TWIST1 suppression in synovial sarcoma
《Cancer Innovation》2024年第2期80-95,共16页Satoru Sasagawa Jun Kumai Toru Wakamatsu Yoshihiro Yui 
Japan Society for Promotion of Science,Grant/Award Numbers:18K09051,21K09338;Children's Cancer Association of Japan(2022)。
Background:Synovial sarcoma(SS)is an SS18-SSX fusion gene-driven soft tissue sarcoma with mesenchymal characteristics,associated with a poor prognosis due to frequent metastasis to a distant organ,such as the lung.His...
关键词：HDAC inhibitor MICA/B SN38 SPHEROID synovial sarcoma TWIST1 
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