SPHEROIDS

作品数：68被引量：109H指数：5
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相关领域：医药卫生更多>>
相关作者：李存江贾建平王宪玲朱依敏胡燕军更多>>
相关机构：首都医科大学宣武医院浙江大学医学院附属妇产科医院中国科学技术大学更多>>
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Optimized Eleutherine bulbosa Urb. bulb extract on the inhibition of 3D retinoblastoma spheroids cultured in type I murine collagen
《International Journal of Ophthalmology(English edition)》2025年第5期802-812,共11页Ammar Akram Kamarudin Nor Hafiza Sayuti Mohamad Zulhafiz Shafiq Zulhilmi Cheng Norazalina Saad Nur Hanisah Azmi Norhaizan Mohd.Esa 
Supported by Universiti Putra Malaysia,Serdang,Selangor,Malaysia(UPM/700-2/1/GPB/2017/9549900).
AIM:To investigate the efficacy of Eleutherine bulbosa(Mill.)Urb.bulb extract(EBE)on the 3D human retinoblastoma cancer cells(WERI-Rb-1)spheroids and explore its apoptotic mechanism.METHODS:The 3D WERI-Rb-1 and human ...
关键词：Eleutherine bulbosa Urb 3D WERI-Rb-1 spheroids APOPTOTIC ANTIOXIDANTS 
Loss of phosphatase and tensin homolog(PTEN)increases Lysyl oxidase-like 2(LOXL2)expression enhancing the growth of fallopian tube epithelial cells as three-dimensional spheroids
《Cancer Pathogenesis and Therapy》2025年第1期68-75,共8页Angela Russo Junlone Moy Manead Khin Timothy R.Dorsey Alfredo Lopez Carrero Joanna E.Burdette 
was supported by the National Institutes of Health(NIH)funding programs R01(Nos:CA240301 and CA240423);the Rivkin Pilot Study Award(No.572533),which constituted a crucial resource for conducting our study.
Background:High-grade serous ovarian cancer(HGSOC)accounts for 70-80%of all ovarian cancer-related deaths.Multiple studies have suggested that the fallopian tube epithelium(FTE)serves as the cell of origin of HGSOC.Ph...
关键词：LOXL2 PTEN PAX2 Fallopian tube Ovarian cancer 
SARS-CoV-2 Omicron Variants Show Attenuated Neurovirulence Compared with the Wild-Type Strain in Elderly Human Brain Spheroids
《Research》2025年第1期107-120,共14页Weikang Chen Xiaobing Jiang Wei Liang Haojie Bai Mingze Xu Zhe Liu Lina Yi Yanming Liu Yanxia Huang Yongxin Zhang Lixia Xu Baoshu Xie Nu Zhang Jun Yu Jing Lu Haipeng Xiao Xiaoxing Li 
supported by Guangdong Science and Technology Program(2021B1212030007)from Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response,National Natural Science Foundation of China(82372624);National Natural Science Foundation of Guangdong Province(2022A1515012430);China Postdoctoral Science Foundation(2022M723588);Medical Scientific Research Foundation of Guangdong Province(A2023439);GuangDong Basic and Applied Basic Research Foundation(2023A1515110422).
Infection with severe acute respiratory syndrome coronavirus 2 Omicron variants still causes neurological complications in elderly individuals.However,whether and how aging brains are affected by Omicron variants in t...
关键词：brain tissue aging brains Omicron variants primary brain spheroids bss Elderly brain spheroids NEUROVIRULENCE 
3D bioprinted chondrogenic gelatin methacrylate-poly(ethylene glycol)diacrylate composite scaffolds for intervertebral disc restoration
《International Journal of Extreme Manufacturing》2025年第1期610-621,共12页Maria D Astudillo Potes Maryam Tilton Indranath Mitra Xifeng Liu Babak Dashtdar Emily T Camilleri Benjamin D Elder Lichun Lu 
supported by NIH Grant(T32GM065841),Mayo Foundation for Education and Research.
Degenerative spine pathologies,including intervertebral disc(IVD)degeneration,present a significant healthcare challenge due to their association with chronic pain and disability.This study explores an innovative appr...
关键词：intervertebral disc regeneration 3D bioprinting gelatin-based hydrogels mesenchymal stem cell spheroids tissue engineering 
Deep phenotyping of testosterone-prompted fibrosis in arrhythmogenic right ventricular cardiomyopathy using iPSC-derived engineered cardiac spheroids
《Bio-Design and Manufacturing》2025年第1期20-35,I0002-I0012,共27页Hongyi Cheng Xinrui Wang Sichong Qian Yike Zhang Jincheng Jiao Bingyu Zheng Yue Zhu Hua Xu Jia Song Feng Zhang Xiaohong Jiang Chang Cui Minglong Chen 
supported by the National Natural Science Foundation of China(Nos.82370322 to CC,82200352 to FZ,82300352 to YZ,22275034 to HX,and 82070343 to MLC);the Natural Science Foundation of Jiangsu Province of China(Nos.BK20220710 to FZ and BK20230733 to YZ);Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.JX13414086 to HYC).
Arrhythmogenic right ventricular cardiomyopathy(ARVC)is a progressive disease characterized by adipose and fibrous replacement of the myocardium.While elevated testosterone levels have been implicated in the pathologi...
关键词：Arrhythmogenic right ventricular cardiomyopathy(ARVC) Gender difference Cardiac spheroids Testoste-rone FIBROSIS 
Framework nucleic Acid-MicroRNA mediated hepatic differentiation and functional hepatic spheroid development for treating acute liver failure
《Bioactive Materials》2024年第11期611-626,共16页Hongyan Wei Tiantian Xue Fenfang Li Enguo Ju Haixia Wang Mingqiang Li Yu Tao 
National Key Research and Development Program of China(2019YFA0111300);Thousand Talents Plan,the Guangdong Provincial Pearl River Talents Program(2019QN01Y131);Medical Science and Technology Research Fund of Guangdong Province(A2022112).
The specific induction of hepatic differentiation presents a significant challenge in developing alternative liver cell sources and viable strategies for clinical therapy of acute liver failure (ALF). The past decade ...
关键词：Hepatic differentiation Framework nucleic acid Functional hepatic spheroids Transcriptome sequencing analysis Acute liver failure therapy 
Spheroid construction strategies and application in 3D bioprinting
《Bio-Design and Manufacturing》2024年第5期800-818,共19页Chunxiang Lu Chuang Gao Hao Qiao Yi Zhang Huazhen Liu Aoxiang Jin Yuanyuan Liu 
supported by the National Natural Science Foundation of China(Nos.61973206,61703265,61803250,and 61933008);the Shanghai Science and Technology Committee Rising-Star Program(No.19QA1403700);the National Center for Translational Medicine(Shanghai)SHU Branch.
Tissue engineering has been striving toward designing and producing natural and functional human tissues.Cells are the fundamental building blocks of tissues.Compared with traditional two-dimensional cultured cells,ce...
关键词：SPHEROIDS STRATEGIES 3D bioprinting BIOFABRICATION 
Designing magnetic microcapsules for cultivation and differentiation of stem cell spheroids
《Microsystems & Nanoengineering》2024年第5期119-131,共13页Kihak Gwon Ether Dharmesh Kianna M.Nguyen Anna Marie R.Schornack Jose Mde Hoyos-Vega Hakan Ceylan Gulnaz Stybayeva Quin P.Peterson Alexander Revzin 
This study was supported in part by the Center for Regenerative Biotherapeutics and Cells to Cures Strategic Initiative at Mayo Clinic,JW.Kieckhefer Foundation,Al Nahvan Foundation,and NIH(DK137231 and P30DK084567).
Human pluripotent stem cells(hPSCs)represent an excellent cell source for regenerative medicine and tissue engineering applications.However,there remains a need for robust and scalable differentiation of stem cells in...
关键词：MAGNETIC enable MICROCAPSULES 
Eye on the Sky: A UAP Research and Field Study off New York’s Long Island Coast
《Open Journal of Applied Sciences》2024年第8期2267-2295,共29页John Joseph Tedesco Gerald Thomas Tedesco 
A ten-month field research study was meticulously conducted at Robert Moses State Park (RMSP) on the south shore of Long Island, NY. The objective was to determine if aerial phenomena of an unknown nature exist over a...
关键词：Unidentified Anomalous Phenomenon (UAP) Forensic Techno-Signatures Office of the Director of National Intelligence (ODNI) Multispectral Electro-Optical (MEO) Ultraviolet A Radiation (UVA) Ultraviolet B Radiation (UVB) Ultraviolet C Radiation (UVC) Visible (VIS) Near-Infrared (NIR) Short-Wave Infrared (SWIR) Long-Wave Infrared (LWIR) Low-Frequency (LF) High-Frequency (HF) Radio-Frequency (RF) Alpha Beta Gamma Ultrasonic X-Band Active Radar Kinematics Aerodynamics Luminous Spheroids Robert Moses State Park (RMSP) 
Porous nanofibrous dressing enables mesenchymal stem cell spheroid formation and delivery to promote diabetic wound healing
《Chinese Journal of Chemical Engineering》2024年第4期156-164,共9页Kexin Zhang Wenmin Zhang Heng An Zhe Huang Yanzhen Wen Xiangyu Jiao Yongqiang Wen 
supported by Fundamental Research Program of Shanxi Province(202203021222199);the Taiyuan University of Science and Technology Scientific Research Initial Funding(20222090);the National Natural Science Foundation of China(21975019).
Delayed and nonhealing of diabetic wounds imposes substantial economic burdens and physical pain on patients.Mesenchymal stem cells(MSCs)promote diabetic wound healing.Particularly when MSCs aggregate into multicellul...
关键词：Electrospinning Homogenization Biomedical engineering Nanomaterials Stem cell spheroids Diabetic wound healing 
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