APOPTOTIC

作品数:245被引量:858H指数:14
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Optimized Eleutherine bulbosa Urb. bulb extract on the inhibition of 3D retinoblastoma spheroids cultured in type I murine collagen
《International Journal of Ophthalmology(English edition)》2025年第5期802-812,共11页Ammar Akram Kamarudin Nor Hafiza Sayuti Mohamad Zulhafiz Shafiq Zulhilmi Cheng Norazalina Saad Nur Hanisah Azmi Norhaizan Mohd.Esa 
Supported by Universiti Putra Malaysia,Serdang,Selangor,Malaysia(UPM/700-2/1/GPB/2017/9549900).
AIM:To investigate the efficacy of Eleutherine bulbosa(Mill.)Urb.bulb extract(EBE)on the 3D human retinoblastoma cancer cells(WERI-Rb-1)spheroids and explore its apoptotic mechanism.METHODS:The 3D WERI-Rb-1 and human ...
关键词:Eleutherine bulbosa Urb 3D WERI-Rb-1 spheroids APOPTOTIC ANTIOXIDANTS 
Fibrous scaffolds loaded with BMSC-derived apoptotic vesicles promote wound healing by inducing macrophage polarization
《Genes & Diseases》2025年第2期398-413,共16页Xudong Su Jianye Yang Zhenghao Xu Li Wei Shuhao Yang Feilong Li Min Sun Yingkun Hu Wenge He Chen Zhao Li Chen Yonghua Yuan Leilei Qin Ning Hu 
supported by the National Natural Science Foundation of China (No.82072443,82372425);the Chongqing Outstanding Project of Overseas Chinese Entrepreneurship and Innovation Support Program (China) (No.CX2022032);the Articular Cartilage Tissue Engineering and Regenerative Medicine Team,Chongqing Medical University (No.W0080);the General Project of Natural Science Foundation of Chongqing,China (No.CSTB2023NSCQMSX0166);the"Tomorrow Cup"Teacher-Student Cocreation Teaching and Research Innovation Project of International Medical College of Chongqing Medical University (No.KY20220204);the Chengdu Medical Research Project (Sichuan,China) (No.2023191);the China Postdoctoral Science Foundation (No.2022M710557);the Natural Science Foundation of Chongqing,China (No.CSTB2023NSCQBHx0011);the Young Excellent Science and Technology Talent Project of the First Affiliated Hospital of Chongqing Medical University (No.ZYRC2022-05).
Macrophages play a key role in wound healing.Dysfunction of their MO polarization to M2 leads to disorders of the wound immune microenvironment and chronic inflammation,which affects wound healing.Regulating the polar...
关键词:Apoptotic body Extracellular vesicles Macrophage polarization Mesenchymal stem cells miR-21a-5p POLYCAPROLACTONE Wound healing 
Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells accelerate tooth extraction socket healing through the jaw vascular unit
《Science China(Life Sciences)》2025年第4期1025-1041,共17页Ruyu Wang Tianxiao Wang Ziyu Chen Jiandong Jiang Yifei Du Hua Yuan Yongchu Pan Yuli Wang 
supported by grants from the Jiangsu Province Capability Improvement Project through Science,Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit(YJXYYJSDW4);Jiangsu Provincial Medical Innovation Center(CXZX202227)。
Delayed tooth extraction socket(TES)healing can cause failure of subsequent oral implantation and increase socioeconomic burden on patients.Excessive amounts of M1 macrophages,apoptotic neutrophils(ANs),and neutrophil...
关键词:BERBERINE human bone marrow mesenchymal stem cells tooth extraction socket macrophages apoptotic neutrophils neutrophil extracellular traps 
Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation
《Neural Regeneration Research》2025年第2期326-342,共17页Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang 
supported by the Hefei Comprehensive National Science Center Hefei Brain Project(to KW);the National Natural Science Foundation of China,Nos.31970979(to KW),82101498(to XW);the STI2030-Major Projects,No.2021ZD0201800(to PH).
Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neur...
关键词:Alzheimer’s disease amyloid deposition apoptotic mechanisms BIOMARKER neural regeneration NEURODEGENERATION repetitive transcranial magnetic stimulation synaptic plasticity 
Caffeic acid-vanadium nanozymes treat skin flap ischemia-reperfusion injury through macrophage reprogramming and the upregulation of X-linked inhibitors of apoptotic proteins
《Acta Pharmaceutica Sinica B》2025年第1期592-610,共19页Xinyu Zhao Jie Shan Hanying Qian Xu Jin Yiwei Sun Jianghao Xing Qingrong Li Xu-Lin Chen Xianwen Wang 
supported by the National Natural Science Foundation of China(Grant Nos.82172204,82372552 and 82372517);the Anhui Key Research and Development Plan(Grant No.202104j07020027,China);the Excellent Youth of Natural Science Research Projects in Anhui Province Universities(2023AH030060);the Basic and Clinical Cooperative Research and Promotion Program of Anhui Medical University(No.2021xkjT028,China);the Research Fund of Anhui Institute of Translational Medicine(2022zhyx-C01,China);the Scientific Research Programme for Higher Education Institutions in Anhui Province(2023AH040371,China).
Ischemia-reperfusion(I/R)injury following skin flap transplantation is a critical factor leading to flap necrosis and transplant failure.Antagonizing inflammatory responses and oxidative stress are regarded as crucial...
关键词:Caffeic acid-vanadium Nanozymes Skin flap ISCHEMIA-REPERFUSION Oxidative stress Inflammation CHEMOKINES Apoptosis 
Apoptotic clearance by stem cells: molecular mechanisms for recognition and phagocytosis of dead cells
《Signal Transduction and Targeted Therapy》2025年第1期18-20,共3页Feng Liu Xiaobo Zhou Ibrahim Akin 
supported by DZHK(German Center for Cardiovascular Research),the BMBF(German Ministry of Education and Research)(No.81Z0500204);the Hector foundation(M2401)and Sichuan Science and Technology Program(2022YFS0610).
In a recent article published in Nature,Stewart and co-workers provide transformative insights into the mechanisms by which hair follicle stem cells(HFSCs)regulate apoptotic cell clearance to maintain tissue fitness.T...
关键词:MECHANISMS MAINTAIN PRECISE 
Antiparasitic and apoptotic modulatory activities of curcumin and extracts of Nigella sativa L,Zingiber officinale Rosc.,and Punica granatum L.in combination with spiramycin against chronic cerebral toxoplasmosis in immunocompromised mice
《Journal of Traditional Chinese Medical Sciences》2024年第4期476-487,共12页Mennat-Elrahman A.Fahmy Amany A.Abdel-Aal Soad I.Hassan Maisa A.Shalaby Manal Badawi Marwa Esmat 
Objective:To examine the effect of coadministration of different medicinal plant extracts(curcumin and extracts of Nigella sativa L.[N.sativa,Jia Hei Zhong Cao],Zingiber officinale Rosc.[Z.officinale,Sheng Jiang],and ...
关键词:Medicinal plants Toxoplasma gondii ME-49 Punica granatum L Cerebral caspase-3 
Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake
《International Journal of Oral Science》2024年第4期643-656,共14页Yawen Cheng Yuan Zhu Yaoshan Liu Xuenan Liu Yanan Ding Deli Li Xiao Zhang Yunsong Liu 
supported by grants from the National Natural Science Foundation of China(No.82170929 and 81970908 to Y.L.);the Beijing Natural Science Foundation(No.7222224 to X.Z.)。
Accumulating evidence has demonstrated that apoptotic vesicles(apoVs)derived from mesenchymal stem cells(MSCs;MSC-apoVs)are vital for bone regeneration,and possess superior capabilities compared to MSCs and other extr...
关键词:APO inductive enriched 
Efferocytosis:A new therapeutic target for stroke
《Chinese Medical Journal》2024年第23期2843-2850,共8页Li Gao Anatol Manaenko Feng Zeng Jingchen Li Lele Liu Ruichuan Xie Xiaohua Zhang John HZhang Qiyong Mei Jiping Tang Qin Hu 
supported by grants from the National Natural Science Foundation of China(Nos.82071283,82371332,and 81801298);the Natural Science Foundation of Shanghai(No.22ZR1437700);the Research Program of Science and Technology Commission of Shanghai Municipality(No.201409005300);Shanghai Engineering Research Center of Peri-operative Organ Support and Function Preservation(No.20DZ2254200).
Efferocytosis refers to the process that phagocytes recognize and remove the apoptotic cells,which is essential for maintaining tissue homeostasis both in physiological and pathological conditions.Numerous studies hav...
关键词:STROKE EFFEROCYTOSIS Inflammation resolution Apoptotic cell clearance 
Promotion of osteochondral repair through immune microenvironment regulation and activation of endogenous chondrogenesis via the release of apoptotic vesicles from donor MSCs被引量:1
《Bioactive Materials》2024年第11期455-470,共16页Guangzhao Tian Han Yin Jinxuan Zheng Rongcheng Yu Zhengang Ding Zineng Yan Yiqi Tang Jiang Wu Chao Ning Xun Yuan Chenxi Liao Xiang Sui Zhe Zhao Shuyun Liu Weimin Guo Quanyi Guo 
Natural Science Foundation of Beijing Municipality(L234024);National Natural Science Foundation of China(82102552);Natural Science Foundation of Guangdong Province(2024A1515030295).
Utilizing transplanted human umbilical cord mesenchymal stem cells(HUMSCs)for cartilage defects yielded advanced tissue regeneration,but the underlying mechanism remain elucidated.Early after HUMSCs delivery to the de...
关键词:Apoptotic vesicles Cartilage regeneration Human umbilical cord mesenchymal stem cells Macrophage polarization Tissue engineering 
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