Supported by Universiti Putra Malaysia,Serdang,Selangor,Malaysia(UPM/700-2/1/GPB/2017/9549900).
AIM:To investigate the efficacy of Eleutherine bulbosa(Mill.)Urb.bulb extract(EBE)on the 3D human retinoblastoma cancer cells(WERI-Rb-1)spheroids and explore its apoptotic mechanism.METHODS:The 3D WERI-Rb-1 and human ...
supported by the National Natural Science Foundation of China (No.82072443,82372425);the Chongqing Outstanding Project of Overseas Chinese Entrepreneurship and Innovation Support Program (China) (No.CX2022032);the Articular Cartilage Tissue Engineering and Regenerative Medicine Team,Chongqing Medical University (No.W0080);the General Project of Natural Science Foundation of Chongqing,China (No.CSTB2023NSCQMSX0166);the"Tomorrow Cup"Teacher-Student Cocreation Teaching and Research Innovation Project of International Medical College of Chongqing Medical University (No.KY20220204);the Chengdu Medical Research Project (Sichuan,China) (No.2023191);the China Postdoctoral Science Foundation (No.2022M710557);the Natural Science Foundation of Chongqing,China (No.CSTB2023NSCQBHx0011);the Young Excellent Science and Technology Talent Project of the First Affiliated Hospital of Chongqing Medical University (No.ZYRC2022-05).
Macrophages play a key role in wound healing.Dysfunction of their MO polarization to M2 leads to disorders of the wound immune microenvironment and chronic inflammation,which affects wound healing.Regulating the polar...
supported by grants from the Jiangsu Province Capability Improvement Project through Science,Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit(YJXYYJSDW4);Jiangsu Provincial Medical Innovation Center(CXZX202227)。
Delayed tooth extraction socket(TES)healing can cause failure of subsequent oral implantation and increase socioeconomic burden on patients.Excessive amounts of M1 macrophages,apoptotic neutrophils(ANs),and neutrophil...
supported by the Hefei Comprehensive National Science Center Hefei Brain Project(to KW);the National Natural Science Foundation of China,Nos.31970979(to KW),82101498(to XW);the STI2030-Major Projects,No.2021ZD0201800(to PH).
Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neur...
supported by the National Natural Science Foundation of China(Grant Nos.82172204,82372552 and 82372517);the Anhui Key Research and Development Plan(Grant No.202104j07020027,China);the Excellent Youth of Natural Science Research Projects in Anhui Province Universities(2023AH030060);the Basic and Clinical Cooperative Research and Promotion Program of Anhui Medical University(No.2021xkjT028,China);the Research Fund of Anhui Institute of Translational Medicine(2022zhyx-C01,China);the Scientific Research Programme for Higher Education Institutions in Anhui Province(2023AH040371,China).
Ischemia-reperfusion(I/R)injury following skin flap transplantation is a critical factor leading to flap necrosis and transplant failure.Antagonizing inflammatory responses and oxidative stress are regarded as crucial...
supported by DZHK(German Center for Cardiovascular Research),the BMBF(German Ministry of Education and Research)(No.81Z0500204);the Hector foundation(M2401)and Sichuan Science and Technology Program(2022YFS0610).
In a recent article published in Nature,Stewart and co-workers provide transformative insights into the mechanisms by which hair follicle stem cells(HFSCs)regulate apoptotic cell clearance to maintain tissue fitness.T...
Objective:To examine the effect of coadministration of different medicinal plant extracts(curcumin and extracts of Nigella sativa L.[N.sativa,Jia Hei Zhong Cao],Zingiber officinale Rosc.[Z.officinale,Sheng Jiang],and ...
supported by grants from the National Natural Science Foundation of China(No.82170929 and 81970908 to Y.L.);the Beijing Natural Science Foundation(No.7222224 to X.Z.)。
Accumulating evidence has demonstrated that apoptotic vesicles(apoVs)derived from mesenchymal stem cells(MSCs;MSC-apoVs)are vital for bone regeneration,and possess superior capabilities compared to MSCs and other extr...
supported by grants from the National Natural Science Foundation of China(Nos.82071283,82371332,and 81801298);the Natural Science Foundation of Shanghai(No.22ZR1437700);the Research Program of Science and Technology Commission of Shanghai Municipality(No.201409005300);Shanghai Engineering Research Center of Peri-operative Organ Support and Function Preservation(No.20DZ2254200).
Efferocytosis refers to the process that phagocytes recognize and remove the apoptotic cells,which is essential for maintaining tissue homeostasis both in physiological and pathological conditions.Numerous studies hav...
Natural Science Foundation of Beijing Municipality(L234024);National Natural Science Foundation of China(82102552);Natural Science Foundation of Guangdong Province(2024A1515030295).
Utilizing transplanted human umbilical cord mesenchymal stem cells(HUMSCs)for cartilage defects yielded advanced tissue regeneration,but the underlying mechanism remain elucidated.Early after HUMSCs delivery to the de...