EFFEROCYTOSIS

作品数：11被引量：22H指数：3
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相关领域：医药卫生更多>>
相关作者：江立生何奔黄晓菁更多>>
相关机构：上海交通大学医学院附属仁济医院南京大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Chinese Medical Journal》《World Journal of Cardiology》《World Journal of Diabetes》更多>>
相关基金：国家自然科学基金中国博士后科学基金更多>>
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Impaired efferocytosis by monocytes and monocyte-derived macrophages in patients with poorly controlled type 2 diabetes
《World Journal of Diabetes》2025年第5期283-296,共14页Qian-Yun Mao Hui Ran Qiu-Yue Hu Sun-Yue He Yao Lu Han Li Yi-Meng Chai Zhao-Yin Chu Xu Qian Wan Ding Yi-Xin Niu Hong-Mei Zhang Xiao-Yong Li Qing Su 
Supported by National Natural Science Foundation of China,No.81970669,No.82170835,and No.82100848;Shanghai Municipal Health Commission,No.202240107,and No.20234Y0040;China Endocrine Metabolism Research Program of Excellence,No.2023-N-03-05。
BACKGROUND Deficient efferocytosis(i.e.,phagocytic clearance of apoptotic cells)by macrophages has been frequently reported in experimental models of type 2 diabetes(T2D).AIM To translate these findings to humans by t...
关键词：Type 2 diabetes EFFEROCYTOSIS MONOCYTE MACROPHAGE 
Efferocytosis:A new therapeutic target for stroke
《Chinese Medical Journal》2024年第23期2843-2850,共8页Li Gao Anatol Manaenko Feng Zeng Jingchen Li Lele Liu Ruichuan Xie Xiaohua Zhang John HZhang Qiyong Mei Jiping Tang Qin Hu 
supported by grants from the National Natural Science Foundation of China(Nos.82071283,82371332,and 81801298);the Natural Science Foundation of Shanghai(No.22ZR1437700);the Research Program of Science and Technology Commission of Shanghai Municipality(No.201409005300);Shanghai Engineering Research Center of Peri-operative Organ Support and Function Preservation(No.20DZ2254200).
Efferocytosis refers to the process that phagocytes recognize and remove the apoptotic cells,which is essential for maintaining tissue homeostasis both in physiological and pathological conditions.Numerous studies hav...
关键词：STROKE EFFEROCYTOSIS Inflammation resolution Apoptotic cell clearance 
Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation
《Bone Research》2024年第3期634-647,共14页Lena Batoon Amy Jean Koh Susan Marie Millard Jobanpreet Grewal Fang Ming Choo Rahasudha Kannan Aysia Kinnaird Megan Avey Tatyana Teslya Allison Robyn Pettit Laurie K.McCauley Hernan Roca 
supported in part by funding from the National Institutes of Health (DK053904,DE022327,AR077539,CA093900,CA046592 and P30 AR069620);National Health and Medical Research Council (APP1143802);Mater Foundation.
Apoptosis is crucial for tissue homeostasis and organ development.In bone,apoptosis is recognized to be a main fate of osteoblasts,yet the relevance of this process remains underexplored.Using our murine model with in...
关键词：development HOMEOSTASIS BONE 
Radiation-based immunogenic vaccine combined with a macrophage“checkpoint inhibitor”for boosting innate and adaptive immunity against metastatic colon cancers
《Acta Pharmaceutica Sinica B》2024年第5期2247-2262,共16页Hongbo Xu Xianya Qin Yuanyuan Guo Siyu Zhao Xingxing Feng Runzan Zhang Tianyi Tian Li Kong Conglian Yang Zhiping Zhang 
This research was supported by the National Natural Science Foundation of China(No.82104098,China);the Program for HUST Academic Frontier Youth Team(No.2018QYTD13,China);Wuhan Science and Technology Plan(2022023702025187,China);Natural Science Foundation of Hubei Province(2023AFD152,China).
Immunogenic dying tumor cells hold promising prospects as cancer vaccines to activate systemic immunity against both primary and metastatic tumors.Especially,X-ray-induced dying tumor cells are rich in highly immunoge...
关键词：Immunogenic cell death Cancer vaccine X-ray EFFEROCYTOSIS MACROPHAGE STING Adaptive immunity Innate immunity 
Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis:Current Knowledge and Future Perspectives被引量：1
《Current Medical Science》2024年第1期1-27,共27页Qi PAN Cheng CHEN Yue-jin YANG 
supported by the National Natural Science Foundation of China(No.81573957,No.81874461 and No.82070307).
Atherosclerosis(AS)is characterized by impairment and apoptosis of endothelial cells,continuous systemic and focal inflammation and dysfunction of vascular smooth muscle cells,which is documented as the traditional ce...
关键词：ATHEROSCLEROSIS TRANSDIFFERENTIATION extracellular traps EFFEROCYTOSIS stem cell nanoparticles 
Oral pathogen aggravates atherosclerosis by inducing smooth muscle cell apoptosis and repressing macrophage efferocytosis被引量：3
《International Journal of Oral Science》2023年第2期332-346,共15页Hanyu Xie Ziyue Qin Ziji Ling Xiao Ge Hang Zhang Shuyu Guo Laikui Liu Kai Zheng Hongbing Jiang Rongyao Xu 
supported by the National Natural Science Foundation of China(grants82001012,81970910,and 81771092);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(grants 19KJA360003);China Postdoctoral Science Foundation(2021M691640)。
Periodontitis imparting the increased risk of atherosclerotic cardiovascular diseases is partially due to the immune subversion of the oral pathogen,particularly the Porphyromonas gingivalis(P.gingivalis),by inducing ...
关键词：IMPAIRED MACROPHAGE cardiovascular 
Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease被引量：3
《Burns & Trauma》2023年第1期245-257,共13页Er-jin Wang Ming-Yue Wu Zheng-yu Ren Ying Zheng Richard D.Ye Chris Soon Heng TAN Yitao Wang Jia-Hong Lu 
supported by the Shenzhen Fundamental Research Program(No.SGDX20210823103804030);Science and Technology Development Fund,Macao SAR(No.0025/2022/A1);the 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund(Guangdong-Hong Kong-Macao Joint Lab)(No.2020B1212030006);Guangdong Basic and Applied Basic Research Foundation(No.2022A1515012416);National Natural Science Foundation of China(No.31871024);the University of Macao grants(No.MYRG2019-00129-ICMS)awarded to JHL.
Inflammatory bowel disease(IBD)is a chronic,non-specific,recurrent inflammatory disease,majorly affecting the gastrointestinal tract.Due to its unclear pathogenesis,the current therapeutic strategy for IBD is focused ...
关键词：AUTOPHAGY Inflammatory bowel diseases INFLAMMATION Tissue repair EFFEROCYTOSIS MACROPHAGE 
Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling被引量：4
《Cellular & Molecular Immunology》2022年第12期1373-1391,共19页Hee Ja Kim Kyungwon Yang Kiyoon Kim Ye‐Ji Lee Sieun Lee Sung Yong Ahn Young‐Ho Ahn Jihee Lee Kang 
supported by National Research Foundation of Korea (NRF) grants (2020R1A5A2019210 and 2020R1A2B5B02001686) funded by the Korean Ministry of Science and ICT.
The interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and metastasis.Cancer-associated fibroblasts(CAFs)play a crucial role in promoting these events through paracrin...
关键词：CAFs Apoptotic lung cancer cells NOTCH1 WISP-1 EFFEROCYTOSIS Migration Invasion Metastasis 
Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution被引量：9
《Bioactive Materials》2022年第3期183-197,共15页Lili Bao Geng Dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin 
This work was supported by National Key Research and Development Program of China(2016YFC1101400);National Natural Science Foundation of China(31800817);Innovative Talent Project of Shaanxi province(2020KJXX-057);National Natural Science Foundation of China(31870970);National Natural Science Foundation of China(81991504);Key Research and Development Program of Shaanxi Province(2019SF-073);Young Talent Support Program of Stomatology of FMMU(41741835-MZ2020D5).
Inflammatory response plays a critical role in myocardial infarction(MI)repair.The neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the the...
关键词：NEUTROPHILS Apoptotic bodies Engineering INFLAMMATION Myocardial infarction 
Efferocytosis in Retinoblastoma
《Journal of Cancer Therapy》2013年第9期1443-1447,共5页Dipankar Das Harsha Bhattacharjee Kasturi Bhattacharjee Prerana S. Tahiliani Pankaj Bhattacharyya Manabjyoti Barman Sumita Sarma Barthakur Panna Deka Apurba Deka Rajashree Paul 
Retinoblastoma has varied presentations. As age advances in retinoblastoma, the undifferentiated tumour is the common appearance. Apoptosis in retinoblastoma in an untreated case can give us a clue about the tumour bi...
关键词：RETINOBLASTOMA APOPTOSIS EFFEROCYTOSIS Vesicles UNDIFFERENTIATED 
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