Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation  

作　　者：Lena Batoon Amy Jean Koh Susan Marie Millard Jobanpreet Grewal Fang Ming Choo Rahasudha Kannan Aysia Kinnaird Megan Avey Tatyana Teslya Allison Robyn Pettit Laurie K.McCauley Hernan Roca 

机构地区：[1]Department of Periodontics and Oral Medicine,University of Michigan,School of Dentistry,Ann Arbor,MI 48109,USA [2]Mater Research Institute,The University of Queensland,Brisbane,QLD 4102,Australia [3]Department of Pathology,University of Michigan,Medical School,Ann Arbor,MI 48109,USA

出　　处：《Bone Research》2024年第3期634-647,共14页骨研究（英文版）

基　　金：supported in part by funding from the National Institutes of Health (DK053904,DE022327,AR077539,CA093900,CA046592 and P30 AR069620);National Health and Medical Research Council (APP1143802);Mater Foundation.

摘　　要：Apoptosis is crucial for tissue homeostasis and organ development.In bone,apoptosis is recognized to be a main fate of osteoblasts,yet the relevance of this process remains underexplored.Using our murine model with inducible Caspase 9,the enzyme that initiates intrinsic apoptosis,we triggered apoptosis in a proportion of mature osteocalcin(OCN^(+))osteoblasts and investigated the impact on postnatal bone development.

关 键 词：development HOMEOSTASIS BONE 

分 类 号：R68[医药卫生—骨科学]