The methylation of DNA is a prevalent epigenetic modification that plays a crucial role in the pathological progression of ocular diseases.DNA methylation can regulate gene expression,thereby affecting cell function a...
Supported by grants from the Zhejiang Medicine and Health Science and Technology Project(No.2018KY748);Ningbo Natural Science Foundation(No.2019A610352);Ningbo Major Scientific and Technological Research and“Unveiling and Commanding”Project(No.2021Z054);Chongqing Science&Technology Commission(No.CSTB2022NSCQ-MSX1413);Ningbo Clinical Research Center for Ophthalmology(No.2022L003);Ningbo Key Laboratory for Neuroretinopathy Medical Research,and the Project of NINGBO Leading Medical&Health Discipline(No.2016-S05).
AIM:To investigate the proliferation regulatory effect of cone-rod homeobox(CRX)in retinal pigment epithelium(RPE)and retinoblastoma(RB)cells to explore the potential application and side effect(oncogenic potential)of...
Following the publication,concerns have been raised about a number of figures in this article.The western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in man...
Context: In Burkina Faso, there is only one retinoblastoma treatment center located in the capital. Nowadays, the treatment of retinoblastoma has benefited from the contribution of scientific progress. Objective: The ...
Background:Intraocular malignant tumors represent a severe disease that threatens vision as well as life.To better extend the life of the patient,preserve visual function,and maintain ocular aesthetics,selecting the a...
supported by the National Key R&D Program of China(2018YFA0801000);the Guangdong Basic and Applied Basic Research Foundation(2023A1515010396);the Science and Technology。
The hindbrain,which develops from the anterior end of the neural tube expansion,can differentiate into the metencephalon and myelencephalon,with varying sizes and functions.The midbrain–hindbrain boundary(MHB)and hin...
supported by grants from the National Natural Science Foundation of China(U2102219,32201779,and 31930018);the Natural Science Foundation of Zhejiang Province(LZ23C020001).
The transition from mitosis to meiosis is a critical event in the reproductive development of all sexually reproducing species.However,the mechanisms that regulate this process in plants remain largely unknown.Here,we...
Background: Retinoblastoma, the most common intraocular pediatric cancer, presents complexities in its genetic landscape that necessitate a deeper understanding for improved therapeutic interventions. This study lever...
Retinoblastoma is the most common intraocular malignant tumor that poses a serious threat to the lives of children.Treatment plans for RB vary depending on the stage of the disease,and there is an uneven distribution ...
Objective Retinoblastoma(RB)is a prevalent type of eye cancer in youngsters.Prospero homeobox 1(Prox1)is a homeobox transcriptional repressor and downstream target of the proneural gene that is relevant in lymphatic,h...