CHEMORESISTANCE

作品数：229被引量：799H指数：13
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相关领域：医药卫生生物学更多>>
相关作者：王锐陈龙邦阙琳玲余四旺曹宝山更多>>
相关机构：南京军区南京总医院中国科学院中山大学同济大学附属同济医院更多>>
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Promising roles of vitamin D receptor and APRO family proteins for the development of cancer stem cells targeted malignant tumor therapy
《Oncology Research》2025年第5期1007-1017,共11页MOEKA NAKASHIMA NAOKO SUGA AKARI FUKUMOTO SAYURI YOSHIKAWA SATORU MATSUDA 
Malignant tumors are heterogeneous diseases characterized by uncontrolled cell proliferation,invasion,metastasis,and/or recurrence of their malignancies.In particular,cancer stem cells(CSCs)within these tumors might b...
关键词：Vitamin D Cancer stem cell INVASION METASTASIS CHEMORESISTANCE Ferroptosis Tumor microenvironment Noncoding RNAs Cancer therapy 
Assessing the impact of CD73 inhibition on overcoming anti-EGFR resistance in glioma cells
《Oncology Research》2025年第4期951-964,共14页LUIZ FERNANDO LOPES SILVA JULIETE NATHALI SCHOLL AUGUSTO FERREIRA WEBER CAMILA KEHL DIAS PAULINE RAFAELA PIZZATO VINÍCIUS PIERDONÁLIMA JEAN SÉVIGNY ANA MARIA OLIVEIRA BATTASTINI FABRÍCIO FIGUEIRÓ 
supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq,n°406035/2021-0 and PQ n°311580/2021-1,FigueiróF);Instituto Nacional de Ciência e Tecnologia-INCT/CNPq/CAPES/FAPERGS Grant no.465671/2014-4;Jean Sévigny received support from the Natural Sciences and Engineering Research Council of Canada(NSERC,RGPIN-2023-05498).
Objectives:Glioblastoma(GB)is a grade IV glial tumor characterized by high malignancy and dismal prognosis,primarily due to high recurrence rates and therapeutic resistance.The epidermal growth factor receptor(EGFR),a...
关键词：Glioblastoma(GB) Epidermal growth factor receptor(EGFR) CD73 CHEMORESISTANCE TYRPHOSTIN 
Impact of poorly controlled type II diabetes mellitus on chemoresistance in colorectal cancer
《World Journal of Gastroenterology》2025年第11期216-221,共6页Aditya Gaur Rick Maity Arkadeep Dhali Jyotirmoy Biswas 
Type 2 diabetes mellitus(T2DM)significantly elevates the risk of colorectal cancer(CRC)and complicates its treatment by promoting chemoresistance.Poor glycemic control has been linked to exacerbated CRC progression an...
关键词：Type 2 diabetes mellitus Colorectal cancer Cancer CHEMORESISTANCE Diabetes mellitus HYPERGLYCEMIA CHEMOTHERAPY 
Hsp90αpromotes chemoresistance in pancreatic cancer by regulating Keap1-Nrf2 axis and inhibiting ferroptosis
《Acta Biochimica et Biophysica Sinica》2025年第2期295-309,共15页Bin Liu Zhiyuan Chen Zhaoxing Li Xinya Zhao Weigang Zhang Ao Zhang Longxing Wen Xiaoming Wang Shuying Zhou Daohai Qian 
supported by the grants from the Anhui Province Educational Natural Science Project(No.2023AH040254);the Anhui Province Health Commission Key Project(No.AHWJ2023BAc10049);the Anhui Province Key Research and Development Project(No.202004j07020051);the Yijishan Hospital Talent Introduction and Peak Plans(Nos.YR202122,GF2019T03,and GF2019G03).
Chemoresistance is the primary reason for poor prognosis in patients with pancreatic cancer(PC).Recent studies have indicated that ferroptosis may improve chemoresistance,but the underlying mechanisms remain unclear.I...
关键词：heat shock protein 90α Keap1-Nrf2 axis ferroptosis pancreatic cancer chemoresistance 
Targeting STAT3 with SH-4-54 suppresses stemness and chemoresistance in cancer stem-like cells derived from colorectal cancer
《World Journal of Clinical Oncology》2025年第2期63-75,共13页Xu-Fan Zhang Qian Chen Qin Jiang Qiong-Ying Hu 
BACKGROUND Over the years,the numbers of treatment options for colorectal cancer(CRC)have increased,leading to notable improvements in the overall survival of CRC patients.Although therapy may initially yield positive...
关键词：SH-4-54 Colorectal cancer Cancer stem-like cells STEMNESS CHEMOSENSITIVITY 
Mechanistic link between long noncoding RNA and stability of oncogene reveals stemness and chemoresistance of hepatocellular carcinoma
《World Journal of Gastroenterology》2025年第7期160-162,共3页Yu-Bo Liang Xing-Ming Chen Wan-Ling Luo Yang Ke 
Supported by the National Natural Science Foundation of China,No.82103173 and No.82460461;Medical Subject Leader of Yunnan Province(General Surgery),No.D-2024029;Yunnan Fundamental Research Project for Excellent Young Scholars,No.202401AW070003;the Young and Mid-aged Academic and Technical Leader Reserve Talent Program of Yunnan Province,No.202205AC160063。
This letter comments on the recently published manuscript by Yu et al,in which the authors revealed a novel mechanism by which the m6A-modified long noncoding RNA kinesin family member 9-antisense RNA 1 promotes stemn...
关键词：Kinesin family member 9-antisense RNA 1 Hepatocellular carcinoma Ubiquitin-specific peptidase 1 Short stature homeobox 2 CHEMORESISTANCE 
Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells
《Cancer Biology & Medicine》2025年第1期48-66,共19页Renjie Chen Jiahui Wang Shuoyu Huang Xuefeng Hu Xinran He Tiange Zhang Yunhan Hu Huijun Wei Sihui Nian Yushu Huang Zhihao Wu 
supported by the National Natural Science Foundation of China(Grant No.81872371);the Open Project Program of State Key Laboratory of Molecular Oncology(Grant No.SKL-KF-2019-11);the Program for Excellent Sci-tech Innovation Teams of Universities in Anhui Province(Grant No.2023AH010073);the Provincial-level Quality Project in Higher Education Institutions of Anhui Province(Grant No.2022jyxm1710);the College Students Innovation and Entrepreneurship Training Program(Grant No.S202310368028 and S202410368035);the Health Science Research Project of Anhui Province(Grant No.AHWJ2022a028)。
Objective:Lung cancer is the most common cause of cancer-related deaths worldwide.Platinum-based chemotherapy is one of the main treatment options for patients with non-small cell lung cancer(NSCLC)but the effectivene...
关键词：CPT1C CHEMORESISTANCE EMT NEDD4L NSCLC 
Poorly controlled type Ⅱ diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage Ⅲ colon cancer
《World Journal of Gastroenterology》2025年第3期29-41,共13页Ruo-Yu Guan Jia-Wei Wu Zi-Yun Yuan Zhi-Yuan Liu Zi-Zhu Liu Zhi-Cong Xiao Jing-Hui Li Cheng-Zhi Huang Jun-Jiang Wang Xue-Qing Yao 
Supported by the Leading Innovation Specialist Support Program of Guangdong Province;the Science and Technology Planning Project of Ganzhou,No.202101074816;the National Natural Science Foundation of China,No.82260501.
BACKGROUND Type Ⅱ diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with metastases.The effects of T2DM on postoperative chemoresistance rate(CRR)and lo...
关键词：Colon cancer CHEMORESISTANCE Diabetes mellitus PROGNOSIS TypeⅡdiabetes mellitus 
Strain and hyaluronic acid interact to regulate ovarian cancer cell proliferation,migration,and drug resistance
《Mechanobiology in Medicine》2024年第4期69-82,共14页Maranda Kramer Allyson Criswell Kamari Marzette Emerson Cutcliffe Mary Kathryn Sewell-Loftin 
funding sources:R00-CA230202(M.K.S.L.);IMPACT Award(O'Neal Comprehensive Cancer Center,M.K.S.L.);the Fine Family Philanthropic Grant(M.K.S.L),UAB Blazer Fellowship(M.K.)and T32-EB023872(M.K.).
The ovarian tumor microenvironment plays a critical yet is poorly understood role in the regulation of cancer cell behaviors including proliferation,migration,and response to chemotherapy treatments.Ovarian cancer is ...
关键词：Ovarian cancer MECHANOBIOLOGY Tumor microenvironment Hyaluronic acid CD44 CHEMORESISTANCE 
Synergistic effects of resveratrol with gemcitabine in pancreatic cancer chemotherapy by inhibiting the c-Met/PARP1 axis
《Journal of Pancreatology》2024年第4期267-278,共12页Shuai Wu Jiaqiang Ren Weikun Qian Mengyuan Gong Jie Li Tao Qin Simei Zhang Wunai Zhang Hao Sun Zheng Wu Zheng Wang Qingyong Ma Wanxing Duan 
supported by grants from the National Natural Science Foundation of China (No.82072699);the Natural Science Basic Research Program of Shaanxi Province,China (Nos.2023-JC-ZD-54 and 2017JM8165).
Objective:Pancreatic cancer is a highly malignant tumor of the digestive tract with a dismal prognosis.A key challenge of pancreatic cancer is its resistance to chemotherapy.The C-mesenchymal-epithelial transition fac...
关键词：CHEMORESISTANCE GEMCITABINE Pancreatic cancer RESVERATROL Synergistic effects 
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