supported by grants from the State’s Key Project of Research and Development Plan(Grant No.2021YFE0110600);the National Natural Science Foundation of China(Grant Nos.82072578 and 82350121);the Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University(Grant No.ZYCXTD2023013)。
This review examined the critical role of adenosine signaling in modulating the behavior of tumor-associated macrophages(TAMs),a key determinant of the tumor microenvironment(TME).Adenosine is an immunosuppressive met...