CD73通过肿瘤微环境调控肝细胞癌的研究进展  

Research progress in the regulation of hepatocellular carcinoma by CD73 through tumor microenvironment

作　　者：戴恒 史会连 孙倩倩 孙丽霞 DAI Heng;SHI Huiian;SUN Qianqian;SUN Lixia(Department of Infectious Diseases,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029;Department of Spleen and Stomach Diseases,Affiliated Hospital of Nanjing University of Chinese Medicine;The First Clinical Medical School of Nanjing University of Chinese Medicine,China)

机构地区：[1]南京中医药大学附属医院感染科,江苏南京210029 [2]南京中医药大学附属医院脾胃病科 [3]南京中医药大学第一临床医学院

出　　处：《胃肠病学和肝病学杂志》2024年第7期942-947,共6页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金面上项目(82374360);国家自然青年科学基金项目(81903974)。

摘　　要：腺苷信号通路是一种广泛存在于人体内的信号调节枢纽,参与了机体细胞的能量供给等一系列生理过程。CD73是嘌呤腺苷通路中一个备受关注的信号蛋白,近年来其在肿瘤发生发展及预后过程中的作用越来越受到重视,尤其是肝细胞癌(hepatocel-lular carcinoma,HCC)领域。CD73在肿瘤微环境下对肝癌的发生、发展、转移具有重要意义,本文着重对CD73介导的腺苷信号通路在肿瘤微环境下原发性肝癌进展过程中的作用机制进行综述,并对CD73作为肝脏恶性肿瘤潜在治疗靶点进行总结,为肝细胞癌的临床诊疗提供新启发。Adenosine signaling pathway is a widely existing signal regulation hub in human body,which is involved in a series of physiological processes such as energy supply of body cells.CD73 is a signaling protein in purine adeno-sine pathway,and its role in tumor development and prognosis has attracted more and more attention in recent years,es-pecially in hepatocellular carcinoma(HCC).CD73 plays an important role in the occurrence,development and metas-tasis of liver cancer in the tumor microenvironment.This paper focused on reviewing the mechanism of action of CD73-mediated adenosine signaling pathway in the progression of primary liver cancer in the tumor microenvironment,and summarized CD73 as a potential therapeutic target for liver cancer,providing new insights for the clinical diagnosis and treatment of HCC.

关 键 词：CD73 腺苷通路 肝细胞癌 综述 

分 类 号：R735.7[医药卫生—肿瘤]