MECHANOBIOLOGY

作品数：59被引量：74H指数：5
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相关领域：医药卫生更多>>
相关机构：贵州中医药大学纽约州立大学更多>>
相关期刊：《Journal of the National Cancer Center》《Biomedical Engineering Communications》《Aggregate》《Journal of Semiconductors》更多>>
相关基金：国家自然科学基金北京市自然科学基金中国博士后科学基金高等学校学科创新引智计划更多>>
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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems被引量：1
《Neural Regeneration Research》2025年第8期2304-2306,共3页Anthony Procès Sylvain Gabriele 
FEDER Prostem Research Project,No.1510614(Wallonia DG06);the F.R.S.-FNRS Epiforce Project,No.T.0092.21;the F.R.S.-FNRS Cell Squeezer Project,No.J.0061.23;the F.R.S.-FNRS Optopattern Project,No.U.NO26.22;the Interreg MAT(T)ISSE Project,which is financially supported by Interreg France-Wallonie-Vlaanderen(Fonds Européen de Développement Régional,FEDER-ERDF);Programme Wallon d’Investissement Région Wallone pour les instruments d’imagerie(INSTIMAG UMONS#1910169);support from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation programme(AdG grant agreement no.834317,Fueling Transport,PI Frédéric Saudou)。
Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary injury.Withi...
关键词：TRAUMATIC INJURY DAMAGE 
Suppression of Cell Traction Force and Enhanced Force Polarity are Key Factors in Vascular Smooth Muscle Cell Differentiation Induced by Low Serum Culture
《Journal of Biosciences and Medicines》2025年第2期243-255,共13页Kazuaki Nagayama Harunobu Tatsuno 
Vascular smooth muscle cells (VSMCs) in the arterial walls play important roles in regulating vascular contraction and dilation. VSMCs actively remodel the arterial walls and dedifferentiate from the contractile to th...
关键词：Cell Biomechanics MECHANOBIOLOGY PHENOTYPE CYTOSKELETON Traction Force Microscopy 
Changes in the Mechanical Environment of the Nucleus with Cell Crowding and Its Effects on DNA Damage Resistance
《Journal of Biosciences and Medicines》2025年第1期230-242,共13页Kazuaki Nagayama Yuto Hirooka 
Nuclear DNA, which is essential for the transmission of genetic information, is constantly damaged by external stresses and is subsequently repaired by the removal of the damaged region, followed by resynthesis of the...
关键词：Cell Biomechanics MECHANOBIOLOGY Mechanical Properties DNA Damage γ-H2A.X 
Harnessing the power of bioprinting for the development of next-generation models of thrombosis
《Bioactive Materials》2024年第12期328-344,共17页Yanyan Liu Tao Huang Nicole Alexis Yap Khoon Lim Lining Arnold Ju 
supported by the National Health and Medical Research Council(NHMRC)of Australia(APP2003904-L.A.J.);NSW Cardiovascular Capacity Building Program(Early-Mid Career Researcher Grant-L.A.J.,H22/98586-K.L.);MRFF Cardiovascular Health Mission Grants(MRF2016165-L.A.J.,MRF2023977-L.A.J.);MRFF Early to Mid-Career Researchers Grant(MRF2028865-L.A.J.);NSW Government Boosting Business Innovation Program(BBIP)International Stream(L.A.J.);National Heart Foundation Vanguard Grant(106979-L.A.J.);Office of Global and Research Engagement(International Sustainable Development Goal Program-L.A.J.);a Snow Medical Research Foundation Fellow(2022SF176);a National Heart Foundation Future Leader Fellow Level 2(105863);an Australian Research Council Future Fellow(FT230100249).
Thrombosis,a leading cause of cardiovascular morbidity and mortality,involves the formation of blood clots within blood vessels.Current animal models and in vitro systems have limitations in recapitulating the complex...
关键词：BIOPRINTING THROMBOSIS MICROFLUIDICS MECHANOBIOLOGY PLATELETS 
Harnessing mechanobiology to enhance cell therapy
《Mechanobiology in Medicine》2024年第4期4-6,共3页Peixiang Ma An Qin Tobias Winkler Jie Zhao 
supported by the National Science Foundation of China(82130073 J.Z.);National Key R&D Program of China(2021YFA1100802 P.M.);Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System,Biomaterials and Regenerative Medicine Institute Cooperative,Research Project,Shanghai Jiaotong University School of Medicine(2022LHA01 J.Z.).
Recent developments in cell therapy have revolutionized medical treatment.While various methods of stimulation have been explored,the role of mechanical force has often been overlooked.Although mechanical loading is n...
关键词：Cell therapy MECHANOBIOLOGY Mechanogenetics Synthetic biology 
Strain and hyaluronic acid interact to regulate ovarian cancer cell proliferation,migration,and drug resistance
《Mechanobiology in Medicine》2024年第4期69-82,共14页Maranda Kramer Allyson Criswell Kamari Marzette Emerson Cutcliffe Mary Kathryn Sewell-Loftin 
funding sources:R00-CA230202(M.K.S.L.);IMPACT Award(O'Neal Comprehensive Cancer Center,M.K.S.L.);the Fine Family Philanthropic Grant(M.K.S.L),UAB Blazer Fellowship(M.K.)and T32-EB023872(M.K.).
The ovarian tumor microenvironment plays a critical yet is poorly understood role in the regulation of cancer cell behaviors including proliferation,migration,and response to chemotherapy treatments.Ovarian cancer is ...
关键词：Ovarian cancer MECHANOBIOLOGY Tumor microenvironment Hyaluronic acid CD44 CHEMORESISTANCE 
From sequence to mechanobiology?Promises and challenges for AlphaFold 3被引量：1
《Mechanobiology in Medicine》2024年第3期1-3,共3页Francesco Zonta Sergio Pantano 
supported by Xi'an Jiaotong-Liverpool University(Research Development Fund RDF-23-01-026 to F.Z);FOCEM(MERCOSUR Structural Convergence Fund-COF 03/11)to S.P.
Interactions between macromolecules orchestrate many mechanobiology processes.However,progress in the field has often been hindered by the monetary and time costs of obtaining reliable experimental structures.In recen...
关键词：AlphaFold Protein folding Biological complexes Structure predictions Drug design 
Tug of war:Understanding the dynamic interplay of tumor biomechanical environment on dendritic cell function
《Mechanobiology in Medicine》2024年第3期7-21,共15页Brian Chesney Quartey Gabriella Torres Mei ElGindi Aseel Alatoom Jiranuwat Sapudom Jeremy C.M Teo 
support from New York University Abu Dhabi(NYUAD)Faculty Research.Fund(AD266)。
Dendritic cells(DCs)play a pivotal role in bridging the innate and adaptive immune systems.From their immature state,scavenging tissue for foreign antigens to uptake,then maturation,to their trafficking to lymph nodes...
关键词：Dendritic cells MECHANOBIOLOGY Biomechanical cues Antigen uptake Antigen presentation Immunotherapy 
The motor-clutch model in mechanobiology and mechanomedicine被引量：1
《Mechanobiology in Medicine》2024年第3期22-30,共9页Zhao Xu Feng Xu Bo Cheng 
Cellular behaviors such as migration,spreading,and differentiation arise from the interplay of cell–matrix interactions.The comprehension of this interplay has been advanced by the motor-clutch model,a theoretical fr...
关键词：MECHANOBIOLOGY Mechanomedicine Molecular-clutch model INTEGRIN Cell migration Cell behavior 
Mechanobiomaterials: Harnessing mechanobiology principles for tissuerepair and regeneration被引量：2
《Mechanobiology in Medicine》2024年第3期64-82,共19页Xiao Lin Hua Yang Yi Xia Kang Wu Fengcheng Chu Huan Zhou Huajian Gao Lei Yang 
supported by the National Natural Science Foundation of China(grant numbers 82025025,U23A6008,32171321,32371385,81802155,51672184 and 81622032);National Key Research and Development Project of China(grant number 2023YFC2412300);Natural Science Foundation of Hebei Province of China(grant number H2022202007);Full-time Talents Program of Hebei Province of China(grant number 2020HBQZYC012);Natural Science Foundation of Tianjin of China(grant number 21JCZDJC01110,21JCYBJC01030);Academician Expert Workstation of Yunnan Province of China(202205AF150025);Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);Key Laboratory of Orthopaedics of Suzhou(SZS2022017);Scientific Research Project of Tianjin Education Commission(2022KJ096);Science and Technology Innovation Project of Foshan City(1920001000025).
Mechanical stimuli are known to play critical roles in mediating tissue repair and regeneration. Recently, thisknowledge has led to a paradigm shift toward proactive programming of biological functionalities of biomat...
关键词：BIOMATERIALS MECHANICS Mechanobiomaterials Tissue repair and regeneration MECHANOBIOLOGY 
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