Platelet indices(PIs)including high mean platelet volume(MPV),plateletcrit(PLC),and platelet distribution width(PLDW)are associated with poor glycemic control.In addition,they can indicate prothrombotic and procoagula...
Supported by the National Natural Science Foundation of China,No.82100639,No.82200630,and No.81970526;Postdoctoral Scientific Research Foundation of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,No.202401023;Clinical Research Program of Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,No.JYLJ202124;Shanghai Municipal Commission of Health and Family Planning,No.20244Y0195 and No.20234Y0132;the Fundamental Research Program Funding of Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,No.JYZZ162;Science Foundation of Xinjiang Uygur Natural Autonomous Region,No.2022D01F17.
BACKGROUND Liver cirrhosis and portal hypertension(PHT)can lead to lymphatic abnormalities and coagulation dysfunction.Because lymphangiogenesis may relieve liver cirrhosis and PHT,the present study investigated the g...
Since the initial observation of carbon nanotubes(CNTs)and graphene platelets(GPLs)in the 1990 and 2000s,the demand for high-performance structural applications and multifunctional materials has driven significant int...
The enhanced myeloid lineage bias of old hematopoietic stem cells(HSCs)has been implicated to underpin the compromised immunity observed upon aging.In a recent paper in Cell,Poscablo and coworkers now present experime...
supported by the Sichuan Science and Technology Program(No.2023YFQ0002);the internal research funds in West China Hospital of Sichuan University(No.19HXCX009);the Medical Science and Technology Project of Sichuan Health Commission(No.21PJ033).
Gliomas are the most common primary neuroepithelial tumors of the central nervous system in adults,of which glioblastoma is the deadliest subtype.Apart from the intrinsically indestructible characteristics of glioma(s...
Background: upper digestive endoscopy is the best method for detecting esophageal varices, but its invasiveness and cost make it inaccessible to certain social classes. Aim: to evaluate the performance of non-invasive...
supported by the Key Program of the National Natural Science Foundation of China(81930090);the National Science Foundation for Distinguished Young Scholars of China(81725019);the National Natural Science Foundation of China(32171104,82273571,and 81874256);the Chongqing Natural Science Foundation(2023NSCQ-MSX0687,CSTB2023NSCQ-JQX0015,and cstc2015jcyjys10001);the Chongqing Talent Program(CQYC20220511002).
Background:The essential roles of platelets in thrombosis have been well recognized.Unexpectedly,thrombosis is prevalent during thrombocytopenia induced by cytotoxicity of biological,physical and chemical origins,whic...
supported by the National Health and Medical Research Council(NHMRC)of Australia(APP2003904-L.A.J.);NSW Cardiovascular Capacity Building Program(Early-Mid Career Researcher Grant-L.A.J.,H22/98586-K.L.);MRFF Cardiovascular Health Mission Grants(MRF2016165-L.A.J.,MRF2023977-L.A.J.);MRFF Early to Mid-Career Researchers Grant(MRF2028865-L.A.J.);NSW Government Boosting Business Innovation Program(BBIP)International Stream(L.A.J.);National Heart Foundation Vanguard Grant(106979-L.A.J.);Office of Global and Research Engagement(International Sustainable Development Goal Program-L.A.J.);a Snow Medical Research Foundation Fellow(2022SF176);a National Heart Foundation Future Leader Fellow Level 2(105863);an Australian Research Council Future Fellow(FT230100249).
Thrombosis,a leading cause of cardiovascular morbidity and mortality,involves the formation of blood clots within blood vessels.Current animal models and in vitro systems have limitations in recapitulating the complex...
supported by the National Natural Science Foundation of China(U23A2070 and 22201223);Chutian Scholar Foundation of Hubei Province and Natural Science Foundation of Hubei Province,China(2022CFA023).
Medical hemostatic gauze is one of the most common agents for bleeding management used in pre-hospital care and clinical treatment.An ideal hemostat requires the features including fast coagulation ability,high biocom...
supported by the National Key Research and Development Program of China(Nos.2022YFC2402400 and 2023YFA0915400);Guangdong Provincial Key Area R&D Program(No.2020B1111540001);the Natural Science Foundation of Guangdong Province(Nos.2024A1515010825,2024A1515030063,2022A1515010780,and 2022A1515011337);Guangdong Province Universities and Colleges Characteristic Innovation(No.2021KTSCX036);Traditional Chinese Medicine Research Project of Guangdong Province Traditional Chinese Medicine Bureau(No.20221206);Shenzhen Medical Research Fund(No.A2303057),Discipline Construction Project of Guangdong Medical University(No.4SG24015G);Construction Project of Nano Technology and Application Engineering Research Center of Guangdong Medical University(No.4SG24179G);Funds for PHD researchers of Guangdong Medical University in 2024.
The antitumor effects of conventional drug carriers are often attenuated and limited in application by biological barriers associated with tumor heterogeneity and resistance brought about by low tumor immunogenicity.W...