Preservation of a youthful path to evergreen platelets?  

作　　者：Sten Eirik W.Jacobsen 

机构地区：[1]Department of Cell and Molecular Biology and Department of Medicine Huddinge,Center for Hematology and Regenerative Medicine,Karolinska Institutet and Karolinska University Hospital Huddinge,Stockholm,Sweden [2]Haematopoietic Stem Cell Biology Laboratory and MRC Molecular Haematology Unit,MRC Weatherall Institute of Molecular Medicine,University of Oxford,Oxford,UK

出　　处：《Cell Research》2025年第2期93-94,共2页细胞研究(英文版)

摘　　要：The enhanced myeloid lineage bias of old hematopoietic stem cells(HSCs)has been implicated to underpin the compromised immunity observed upon aging.In a recent paper in Cell,Poscablo and coworkers now present experimental support for also the dysregulated function of platelets seen during aging,emanating at the aged HSC level;they identified an aging-and platelet-specific differentiation pathway in mice,which,compared to the canonical pathway dominating in young mice,replenishes megakaryocyte progenitors which with faster kinetics and enhanced regenerative potential produce hyper-reactive platelets.

关 键 词：PLATELETS IMMUNITY HEMATOPOIETIC 

分 类 号：R339.4[医药卫生—人体生理学]