HEMATOPOIETIC

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A novel research model of clonal evolution in mantle cell lymphoma at the single-cell genomic level
《Genes & Diseases》2025年第3期35-38,共4页Li Zhang Yongsheng Liu Liang Wang Li Wang Li Zheng Wei He Li Yan Lvsu Ye Huidan Zhang Junling Tang 
funded by the Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau,China)(No.2023GGXM006,2024ZDXM026,2024MSXM115);the Key Research Project from Science and Technology Department of Sichuan Province,China(No.2019YFS0301);the Chongqing Key Municipal Public Health Specialty Construction Project(China);the Key Research Project from Chongqing Medical and Pharmaceutical Vocational Education Group(China)(No.CQZJ202329);the Incubation Project of the First Affiliated Hospital of Chongqing Medical and Pharmaceutical College(China)(No.2022-2023ZD04,2022-2023ZD03,2022-2023MS04,2022-2023MS03,2022-2023MS010);the Science and Technology Research Program of Chongqing Education Commission(China)(No.KJQN202302811).
Mantle cell lymphoma(MCL)is recognized as one of the most genetically heterogeneous diseases,with high instability at the genomic level.MCL is common in males with a male-to-female ratio of about 2:1,and its incidence...
关键词：hematopoietic lineage mantle cell lymphoma mcl clonal evolution genomic instability tumor immunity evolution tree single cell genomic level genetic heterogeneity mantle cell lymphoma 
Phenanthrene perturbs hematopoietic development and causes hematopoietic defects in zebrafish
《Journal of Environmental Sciences》2025年第5期573-581,共9页Lingyu Ren Yue Wang Ying Ren Guangke Li Nan Sang 
supported by the National Natural Science Foundation of China(Nos.22276117 and 22076108);the Science and Technology Innovation Talent Team Project of Shanxi Province(No.202204051002024).
Phenanthrene(Phe)is one of the common polycyclic aromatic hydrocarbons in the environment,and recent studies show that it can cause cardiac developmental toxicity and immunotoxicity.However,it is still unknown whether...
关键词：PHENANTHRENE ZEBRAFISH Hematopoietic development Hematopoietic defect 
Preservation of a youthful path to evergreen platelets?
《Cell Research》2025年第2期93-94,共2页Sten Eirik W.Jacobsen 
The enhanced myeloid lineage bias of old hematopoietic stem cells(HSCs)has been implicated to underpin the compromised immunity observed upon aging.In a recent paper in Cell,Poscablo and coworkers now present experime...
关键词：PLATELETS IMMUNITY HEMATOPOIETIC 
Rab1 and Syntaxin 17 regulate hematopoietic homeostasis through β-integrin trafficking in Drosophila
《Journal of Genetics and Genomics》2025年第1期51-65,共15页Fangzhou Luo Luwei Sui Ying Sun Zhixian Lai Chengcheng Zhang Gaoqun Zhang Bing Bi Shichao Yu Li Hua Jin 
supported by the National Natural Science Foundation of China(32170484 and 32300384);the Fundamental Research Funds for the Central Universities(2572022DQ07 and 2572020AW04).
Hematopoiesis is crucial for organismal health,and Drosophila serves as an effective genetic model due to conserved regulatory mechanisms with vertebrates.In larvae,hematopoiesis primarily occurs in the lymph gland,wh...
关键词：HEMATOPOIESIS Lymphgland Rab1 Syntaxin 17 β-integrin DROSOPHILA 
Characterization of gene regulatory networks underlying key properties in human hematopoietic stem cell ontogeny
《Cell Regeneration》2024年第1期287-304,共18页Yazhou Cuiand Guangjin Pan Fei Li Yanling Zhu Tianyu Wang Jun Tang Yuhua Huang Jiaming Gu Yuchan Mai Mingquan Wang Zhishuai Zhang Jiaying Ning Baoqiang Kang Junwei Wang Tiancheng Zhou Yazhou Cui Guangjin Pan 
National Key Research and Development Program of China,Stem Cell and Translational Research(2022YFA1105001);Research Funds from Health@InnoHK Program launched by Innovation Technology Commission of the Hong Kong SAR,P.R.China;National Natural Science Foundation of China(31971374,32171451);Science and Technology Planning Project of Guangdong Province,China(2023B1212060050,2023B1212120009);Youth Innovation Promotion Association of the Chinese Academy of Sciences(to Y.Z.2023373);China Postdoctoral Science Foundation Funded Project(2023M733516);Fountain-Valley Life Sciences Fund of University of Chinese Academy of Sciences Education Foundation(ZXXM202201);Guangzhou Key Research and Development Program(202206010041);Guangzhou Science and Technology Program General project(2024A04J3801);Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine(2020B1212060052);Guangdong Province Special Program for Outstanding Talents(to G.P.,2019JC05Y463).
Human hematopoiesis starts at early yolk sac and undergoes site-and stage-specific changes over development.The intrinsic mechanism underlying property changes in hematopoiesis ontogeny remains poorly understood.Here,...
关键词：Hematopoietic stem cell Transcription factors Lineage potential Gene regulatory networks Human induced pluripotent stem cells Hematopoietic differentiation 
Epigenetic modifications in hematopoietic ecosystem:a key tuner from homeostasis to acute myeloid leukemia
《Blood Science》2024年第4期3-12,共10页Shuxin Yao Rongxia Guo Wen Tian Yanbing Zheng Jin Hu Guoqiang Han Rong Yin Fuling Zhou Haojian Zhang 
supported by the grants to H.Z.from the National Key R&D Program of China(2022YFA0103200);the National Natural Science Foundation of China(82325003,82230007);supported by the grants to R.G.from the Fundamental Research Funds for the Central Universities(2042023kf0057);the National Natural Science Foundation(NSFC)(82301997);supported by the grants to R.Y.from the National Natural Science Foundation of China(82200188);the Special Fund of China Postdoctoral Science Foundation(2022TQ0238);supported by the grants to H.Z.from the Fundamental Research Funds for the Central Universities(2042022dx0003 and 2042024kf1022).
Hematopoietic stem cells(HSCs)maintain homeostasis in the hematopoietic ecosystem,which is tightly regulated at multiple layers.Acute myeloid leukemia(AML)is a severe hematologic malignancy driven by genetic and epige...
关键词：Acute myeloid leukemia DNA methylation HEMATOPOIESIS Hematopoietic stem cells Leukemia stem cells RNA modification 
New insights into the endothelial origin of hematopoietic system inspired by“TIF”approaches
《Blood Science》2024年第4期27-35,共9页Siyuan Hou Xia Guo Junjie Du Xiaochen Ding Xiaowei Ning Haizhen Wang Haifeng Chen Bing Liu Yu Lan 
supported by the National Key R&D Program of China(2022YFA110350 and 2020YFA0112400);State Key Laboratory of Experimental Hematology Research Grant(ZK23-04);the National Natural Science Foundation of China(82000111).
Hematopoietic stem progenitor cells(HSPCs)are derived from a specialized subset of endothelial cells named hemogenic endothelial cells(HECs)via a process of endothelial-to-hematopoietic transition during embryogenesis...
关键词：Endothelial-to-hematopoietic transition Genetic lineage tracing Hematopoietic stem progenitor cells Hemogenic endothelial cell Single-cell technology 
Rejuvenating immunity through a balancing stem cell act
《Cell Research》2024年第12期826-827,共2页Sten Eirik W.Jacobsen 
An alteration in the lineage bias of aged hematopoietic stem cells (HSCs) has been implicated in the reduced immunity observed upon aging. Ross and colleagues now provide direct support for this hypothesis, demonstrat...
关键词：IMMUNITY HEMATOPOIETIC depletion 
Protective effect of Camellia nitidissima Chi onγrays radiation-induced hematopoietic and gastrointestinal damage
《Acupuncture and Herbal Medicine》2024年第4期487-499,共13页Zhiyun Wang Haihua Shang Wenfeng Gou Feifei Xu Yue Hou Gaiting Liu Zhonghao Ren Yiliang Li Yuhua Tian Wei Li Yuefei Wang Wenbin Hou 
sponsored by the National Natural Science Foundation of China(82303681 and 82202950);Fundamental Research Funds for the Central Universities(3332022063);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-042);The National Natural Science Foundation of China(82202950);the Fundamental Research Funds for the Central Universities(3332022063);Feifei Xu,who participated in the research design.The National Natural Science Foundation of China(82303681);Wenfeng Gou,who participated in the research design;The Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-042);Wenbin Hou,who designed and conceived the study.
Objective:Camellia nitidissima Chi,a Chinese medicine commonly used by ethnic minorities in Guangxi,China,is beneficial for clearing heat,detoxifying,inducing diuresis,and suppressing swelling.It has various pharmacol...
关键词：Antioxidant capacity Camellia nitidissima Chi Gastrointestinal system Hematopoietic system RADIOPROTECTION 
Hematopoietic Stem Cell Niche in Foetal Liver and Production of Pluripotent Stem Cell-Derived Liver Organoids
《Journal of Biosciences and Medicines》2024年第11期433-456,共24页Jingyi Cui 
There is a considerable demand but limited supply for hematopoietic stem cells (HSCs) in clinics. To meet clinical needs of HSCs, new efforts focus on de novo HSCs generation from pluripotent stem cells (PSCs). Althou...
关键词：Hematopoietic Stem Cell (HSC) HSC Maturation Fetal Liver Niche Fetal Liver Organoid 
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