Epigenetic modifications in hematopoietic ecosystem:a key tuner from homeostasis to acute myeloid leukemia  

作　　者：Shuxin Yao Rongxia Guo Wen Tian Yanbing Zheng Jin Hu Guoqiang Han Rong Yin Fuling Zhou Haojian Zhang 

机构地区：[1]State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School&Hospital of Stomatology,Wuhan University,Wuhan,China [2]Department of Hematology,Zhongnan Hospital,Medical Research Institute,Wuhan University,Wuhan,China [3]Frontier Science Center for Immunology and Metabolism,Medical Research Institute,Wuhan University,Wuhan,China [4]Department of Laboratory Medicine,Zhongnan Hospital of Wuhan University,Wuhan,China [5]Taikang Center for Life and Medical Sciences,Wuhan University,Wuhan,China

出　　处：《Blood Science》2024年第4期3-12,共10页血液科学(英文)

基　　金：supported by the grants to H.Z.from the National Key R&D Program of China(2022YFA0103200);the National Natural Science Foundation of China(82325003,82230007);supported by the grants to R.G.from the Fundamental Research Funds for the Central Universities(2042023kf0057);the National Natural Science Foundation(NSFC)(82301997);supported by the grants to R.Y.from the National Natural Science Foundation of China(82200188);the Special Fund of China Postdoctoral Science Foundation(2022TQ0238);supported by the grants to H.Z.from the Fundamental Research Funds for the Central Universities(2042022dx0003 and 2042024kf1022).

摘　　要：Hematopoietic stem cells(HSCs)maintain homeostasis in the hematopoietic ecosystem,which is tightly regulated at multiple layers.Acute myeloid leukemia(AML)is a severe hematologic malignancy driven by genetic and epigenetic changes that lead to the transformation of leukemia stem cells(LSCs).Since somatic mutations in DNA methylation-related genes frequently occur in AML,DNA methylation is widely altered and functions as a starting engine for initiating AML.Additionally,RNA modifications,especially N^(6)-methyladenosine(m^(6)A),also play an important role in the generation and maintenance of the hematopoietic ecosystem,and AML development requires reprogramming of m^(6)A modifications to facilitate cells with hallmarks of cancer.Given the complex pathogenesis and poor prognosis of AML,it is important to fully understand its pathogenesis.Here,we mainly focus on DNA methylation and RNA m^(6)A modification in hematopoiesis and AML and summarize recent advances in this field.

关 键 词：Acute myeloid leukemia DNA methylation HEMATOPOIESIS Hematopoietic stem cells Leukemia stem cells RNA modification 

分 类 号：R73[医药卫生—肿瘤]