HEMATOPOIESIS

作品数：121被引量：270H指数：5
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The link between ten-eleven translocation-2(Tet2)related clonal hematopoiesis and sequential onset of two hematologic malignancies
《Genes & Diseases》2025年第1期14-18,共5页Jin Huang Haolong Lin Xia Mao Min Xiao Xiaoxi Zhou Qilin Ao Liang Huang 
supported by funding from the National Natural Science Foundation of China(No.82070211 to Liang Huang,No.82170167 to Xiaoxi Zhou,No.81800356 to Jin Huang);the National Key R&D Program of China(No.2022YFC2502604 to Liang Huang).
of somatic mutations of genes known to be recurrently mutated in hematologic malignancies in the peripheral blood of healthy individuals.1 When clonal hematopoiesis is associated with a mutation at a variant allele fr...
关键词：MALIGNANCIES HEMATOPOIESIS ALLELE 
Rab1 and Syntaxin 17 regulate hematopoietic homeostasis through β-integrin trafficking in Drosophila
《Journal of Genetics and Genomics》2025年第1期51-65,共15页Fangzhou Luo Luwei Sui Ying Sun Zhixian Lai Chengcheng Zhang Gaoqun Zhang Bing Bi Shichao Yu Li Hua Jin 
supported by the National Natural Science Foundation of China(32170484 and 32300384);the Fundamental Research Funds for the Central Universities(2572022DQ07 and 2572020AW04).
Hematopoiesis is crucial for organismal health,and Drosophila serves as an effective genetic model due to conserved regulatory mechanisms with vertebrates.In larvae,hematopoiesis primarily occurs in the lymph gland,wh...
关键词：HEMATOPOIESIS Lymphgland Rab1 Syntaxin 17 β-integrin DROSOPHILA 
Association Between Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Patients With Acute Coronary Syndrome Who Have Quit Smoking:Study Design of a Prospective Cohort Study
《Cardiology Discovery》2024年第4期280-283,共4页Jing Li Zizhao Qi Ying Xu Yinan Cao Yi Li Yaling Han 
funded by Liaoning Provincial Science and Technology Project(2022-MS-045).
Despite quitting smoking,patients with acute coronary syndrome(ACS)still have an increased risk of cardiovascular events.Clonal hematopoiesis of indeterminate potential(CHIP),which may be induced by smoking,has been i...
关键词：Acute coronary syndrome Clonal hematopoiesis of indeterminate potential SMOKING Cardiovascular events 
Roles of Setbp1 in developmental hematopoiesis and acute myeloid leukemia
《Genes & Diseases》2024年第6期16-19,共4页Fei Ao Fan Chen Minhong Lv Yuming Cao Jinfeng Xu Jingbo Xu Anskar Yu-Hung Leung Qiwen Yuan Li Wang Bailiang He 
supported by grants from the National Natural Science Foundation of China (No.32000569);the Basic and Applied Basic Research Foundation of Guangdong Province,China (No.2019A1515110281).
Gain-of-function somatic mutations of SET binding protein 1(SETBP1)result in the accumulation of SETBP protein and are detected in 17%of secondary acute myeloid leukemia(AML)patients.1 In fact,high expression of SETBP...
关键词：ACUTE MYELOID LEUKEMIA 
Epigenetic modifications in hematopoietic ecosystem:a key tuner from homeostasis to acute myeloid leukemia
《Blood Science》2024年第4期3-12,共10页Shuxin Yao Rongxia Guo Wen Tian Yanbing Zheng Jin Hu Guoqiang Han Rong Yin Fuling Zhou Haojian Zhang 
supported by the grants to H.Z.from the National Key R&D Program of China(2022YFA0103200);the National Natural Science Foundation of China(82325003,82230007);supported by the grants to R.G.from the Fundamental Research Funds for the Central Universities(2042023kf0057);the National Natural Science Foundation(NSFC)(82301997);supported by the grants to R.Y.from the National Natural Science Foundation of China(82200188);the Special Fund of China Postdoctoral Science Foundation(2022TQ0238);supported by the grants to H.Z.from the Fundamental Research Funds for the Central Universities(2042022dx0003 and 2042024kf1022).
Hematopoietic stem cells(HSCs)maintain homeostasis in the hematopoietic ecosystem,which is tightly regulated at multiple layers.Acute myeloid leukemia(AML)is a severe hematologic malignancy driven by genetic and epige...
关键词：Acute myeloid leukemia DNA methylation HEMATOPOIESIS Hematopoietic stem cells Leukemia stem cells RNA modification 
Gut microbiota plays pivotal roles in benign and malignant hematopoiesis
《Blood Science》2024年第4期13-21,共9页Yuxuan Li Biao Zhang Lingli Jiang Tao Cheng Hui Cheng Pengxu Qian 
supported by grants from the National Key Research and Development Program of China(2022YFA1103500,2020YFE0203000);the National Natural Science Foundation of China(81890990,82222003,92268117,82161138028);the Zhejiang Provincial Natural Science Foundation of China(Z24H080001);the Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00016);the CAMS Initiative for Innovative Medicine(2021-I2M-1-019).
Accumulated evidence emerges that dynamic changes in human gut microbiota and microbial metabolites can alter the ecological balance of symbiotic hosts.The gut microbiota plays a role in various diseases through diffe...
关键词：Fecal microbiota transplantation Graft-versus-host disease Gut microbiota Hematologic diseases Hematopoietic stem cells 
Amphiphilic cytokine traps remodel marrow adipose tissue for hematopoietic microenvironment amelioration
《Bioactive Materials》2024年第12期226-240,共15页Shunshu Deng Shuang Zhang Tong Shen Xuanlin Wang Zehua Gao Wenchao Zhang Kai Dai Jing Wang Changsheng Liu 
supported by the Basic Science Center Program of National Natural Science Foundation of China(No.T2288102);the Key Program of the National Natural Science Foundation of China(No.32230059);the National Natural Science Foundation of China(No.32301123);the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry(No.JKVD1211002);the Wego Project of Chinese Academy of Sciences[No.(2020)005];the China Postdoctoral Science Foundation(No.2022M721147);the Project of National Facility for Translational Medicine(Shanghai)(No.TMSK-2021-134);the Peak Disciplines(Type IV)of Institutions of Higher Learning in Shanghai.
Hematopoietic stem cell transplantation(HSCT)is extensively employed in the treatment of hematological malignancies but is markedly constrained by the paucity of hematopoietic stem/progenitor cells(HSPCs).Recent studi...
关键词：ADIPOCYTES HEMATOPOIESIS In vivo osteo-organoids Stem cell factor Sulfated chitosan Tissue regeneration 
Can dental problems be indicative of clonal hematopoiesis?
《Cell Research》2024年第12期824-825,共2页Soichi Sano Kenneth Walsh 
A new study published in Cell provides evidence that clonal hematopoiesis of indeterminate potential(CHIP)can promote bone loss in periodontal disease and rheumatoid arthritis through pro-inflammatory mechanisms.
关键词：mechanisms. HEMATOPOIESIS CLONAL 
Integrative cross-species transcriptome analysis reveals earlier occurrence of myelopoiesis in pre-circulation primates compared to mice
《Zoological Research》2024年第6期1276-1286,共11页Junjie Du Zongcheng Li Yandong Gong Yu Lan Bing Liu 
supported by the Beijing Natural Science Foundation(5222035);Beijing Nova Program(Z211100002121033,20230484407);National Key R&D Program of China(2021YFA0805703,2021YFA1100901,2022YFA1105700);National Natural Science Foundation of China(31930054,32100646,82370107,82270118);Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2017ZT07S347)。
Hematopoiesis originates in the yolk sac,which forms prior to the establishment of blood circulation and exhibits distinct developmental processes between primates and mice.Despite increasing appreciation of yolk sac ...
关键词：Yolk sac HEMATOPOIESIS Macrophage Integrative analysis Single-cell RNA sequencing 
Fufang E’jiao Jiang’s effect on immunity,hematopoiesis,and angiogenesis via a systematic“compound-effect-target”analysis
《Food Science and Human Wellness》2024年第5期2813-2832,共20页Xiang Li Xiao Xu Ying Dong Shusheng Fan Xueyang Ren Yuan Zheng Jiamu Ma Feng Zhang Qingyue Deng Xianxian Li Yingyu He Mengyu Sun Wei Liu Mengxia Li Qing Xia Yan Zhang Gaimei She 
supported by the National Key R&D Program of China(2018YFC1707300);the Taishan Industrial Experts Program(tscx202211148).
Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive im...
关键词：Fufang E’jiao Jiang Zebrafish(Danio rerio) Network pharmacology TRANSCRIPTOME BIBLIOMETRICS 
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