Gut microbiota plays pivotal roles in benign and malignant hematopoiesis  

作　　者：Yuxuan Li Biao Zhang Lingli Jiang Tao Cheng Hui Cheng Pengxu Qian 

机构地区：[1]State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Haihe Laboratory of Cell Ecosystem,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China [2]Tianjin Institutes of Health Science,Center for Stem Cell Medicine,Chinese Academy of Medical Sciences,Department of Stem Cell&Regenerative Medicine,Peking Union Medical College,Tianjin 300020,China [3]Center for Stem Cell and Regenerative Medicine and Bone Marrow Transplantation Center of the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China [4]Liangzhu Laboratory,Zhejiang University,1369 West Wenyi Road,Hangzhou 311121,China [5]Institute of Hematology,Zhejiang University&Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy,Hangzhou 310058,China

出　　处：《Blood Science》2024年第4期13-21,共9页血液科学(英文)

基　　金：supported by grants from the National Key Research and Development Program of China(2022YFA1103500,2020YFE0203000);the National Natural Science Foundation of China(81890990,82222003,92268117,82161138028);the Zhejiang Provincial Natural Science Foundation of China(Z24H080001);the Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00016);the CAMS Initiative for Innovative Medicine(2021-I2M-1-019).

摘　　要：Accumulated evidence emerges that dynamic changes in human gut microbiota and microbial metabolites can alter the ecological balance of symbiotic hosts.The gut microbiota plays a role in various diseases through different mechanisms.More and more attention has been paid to the effects that human microbiota extends beyond the gut.This review summarized the current understanding of the roles that gut microbiota plays in hematopoietic regulation and the occurrence and development of benign and malignant hematologic diseases.The progress of the application of microbiota in treatment was discussed in order to provide new insights into clinical diagnosis and treatment in the future.

关 键 词：Fecal microbiota transplantation Graft-versus-host disease Gut microbiota Hematologic diseases Hematopoietic stem cells 

分 类 号：R73[医药卫生—肿瘤]