The link between ten-eleven translocation-2(Tet2)related clonal hematopoiesis and sequential onset of two hematologic malignancies  

作　　者：Jin Huang Haolong Lin Xia Mao Min Xiao Xiaoxi Zhou Qilin Ao Liang Huang 

机构地区：[1]Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [2]Institute of Pathology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [3]Department of Pathology,School of Basic Medical Science,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [4]State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Haihe Laboratory of Cell Ecosystem,Institute of Hematology & Blood Diseases Hospital,Chinese Academy of Medical Science & Peking Union Medical College,Tianjin 300020,China [5]Tianjin Institutes of Health Science,Tianjin 301600,China

出　　处：《Genes & Diseases》2025年第1期14-18,共5页基因与疾病(英文)

基　　金：supported by funding from the National Natural Science Foundation of China(No.82070211 to Liang Huang,No.82170167 to Xiaoxi Zhou,No.81800356 to Jin Huang);the National Key R&D Program of China(No.2022YFC2502604 to Liang Huang).

摘　　要：of somatic mutations of genes known to be recurrently mutated in hematologic malignancies in the peripheral blood of healthy individuals.1 When clonal hematopoiesis is associated with a mutation at a variant allele frequency of 0.02 or greater,it is termed"clonal hematopoiesis of indeterminate potential"(CHIP).Classical CHIP genes include epigenetic modifiers such as Dnmt3a,Tet2,and Asxl1,and DNA repair genes such as Tp53 and Ppm1d.2 Although CHIP-associated mutations are most frequent in myeloid neoplasm,some,such as those in Dnmt3a and Tet2,are recurrently observed in lymphoid malignancies as well.

关 键 词：MALIGNANCIES HEMATOPOIESIS ALLELE 

分 类 号：R733.7[医药卫生—肿瘤]