MYELOID

作品数：312被引量：519H指数：9
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Lengthening of the CHURC1 3'untranslated region by alternative polyadenylation is associated with the progression of acute myeloid leukemia
《Genes & Diseases》2025年第1期106-109,共4页Xi Hu Panxiang Cao Fang Wang Huqin Zhang Tong Wang Hongxing Liu Xiaoming Wu 
supported by the Technology Innovation Leading Program of Shaanxi,China(No.2023KXJ-219);the Science and Technology Program of Shaanxi Province,China(No.2022LL-ZD-01HZ).
Alternative polyadenylation(APA)is a post-transcriptional process that typically determines the length of mature mRNAs'3'untranslated region(3'UTR).The global shortened 3'UTR alters mRNA stability,localization,and tra...
关键词：URC MYELOID ACUTE 
Roles of Setbp1 in developmental hematopoiesis and acute myeloid leukemia
《Genes & Diseases》2024年第6期16-19,共4页Fei Ao Fan Chen Minhong Lv Yuming Cao Jinfeng Xu Jingbo Xu Anskar Yu-Hung Leung Qiwen Yuan Li Wang Bailiang He 
supported by grants from the National Natural Science Foundation of China (No.32000569);the Basic and Applied Basic Research Foundation of Guangdong Province,China (No.2019A1515110281).
Gain-of-function somatic mutations of SET binding protein 1(SETBP1)result in the accumulation of SETBP protein and are detected in 17%of secondary acute myeloid leukemia(AML)patients.1 In fact,high expression of SETBP...
关键词：ACUTE MYELOID LEUKEMIA 
Single-cell analyses revealed key tumor-infiltrating myeloid cell subsets associated with clinical outcomes in different subtypes of breast cancer
《Genes & Diseases》2024年第6期32-35,共4页Dingjie Wu Si Chen Yijin Liu Bowen Yang Ruixin Li Feng Jin Fan Yao Yue Fang 
supported by the National Natural Science Foundation of China (No.81974418);Basic Research Project of Liaoning Province (No.JC2019002);Doctoral Start-up Foundation of Liaoning Province (No.2019-BS-284);Youth backbone Support Program of China Medical University (No.QGZ2018081).
Breast cancer is the most common cancer and the leading cause of cancer death in women worldwide.1 Tumor-infiltrating myeloid cells(TiMs),key components of tumor microenvironment,are considered to be potential therape...
关键词：BREAST infiltrating MYELOID 
Leser-Trélat Associated with Myeloproliferative Neoplasia: When the Skin Speaks
《Journal of Biosciences and Medicines》2024年第12期335-341,共7页David Fernando Ortiz-Pérez Mario Enrique Montoya-Jaramillo Juan Diego Emiliani-Cortes Kiara Patricia Flórez-Theran Karen Andrea Sierra-Tapia Mariana Hernández-Salgado Maria Alejandra Torres-Contreras Manuel Fernando Chavarro-Muñoz Dariel Stiven Rojas-Cumaco Cristian Alberto Lobo-Ardila Juan José Iles-Bravo José Giovanni Argel-Esquivel 
The Leser-Trélat sign is an uncommon dermatological manifestation characterized by the sudden and rapid onset of multiple seborrheic keratoses, variably distributed across the body. Its clinical significance lies in ...
关键词：Leser-Trélat Sign Paraneoplastic Syndromes Seborrheic Keratosis LEUKEMIA MYELOID Acute 
Improving risk stratification for 2022 European LeukemiaNet favorablerisk patients with acute myeloid leukemia
《The Innovation》2024年第6期89-99,共11页Kellie J.Archer Han Fu Krzysztof Mrózek Deedra Nicolet Alice S.Mims Geoffrey L.Uy Wendy Stock John C.Byrd Wolfgang Hiddemann Klaus H.Metzeler Christian Rausch Utz Krug Cristina Sauerland Dennis Görlich Wolfgang E.Berdel Bernhard J.Woermann Jan Braess Karsten Spiekermann Tobias Herold Ann-Kathrin Eisfeld 
supported by the National Library of Medicine of the National Institutes of Health under award R01LM013879;Research reported in this publication was also supported in part by the National Cancer Institute at the National Institutes of Health under award R01CA262496,R01CA284595,R01CA283574,U10CA180821,U10CA180882,U24CA196171,UG1CA233327,UG1CA233331,UG1CA233338,UG1CA 233339,R35CA197734,and P30CA016058;the Coleman Leukemia Research Foundation;an ASH Junior Faculty Scholar Award and ASH Bridge Grant(to A.-K.E.);the Leukemia Research Foundation(to A.-K.E.);the Leukemia&Lymphoma Society(to A.-K.E.);The D.Warren Brown Foundation。
Assignment of patients diagnosed with acute myeloid leukemia(AML)to the 2022 European LeukemiaNet(ELN)favorable genetic risk group has important clinical implications,as allogeneic stem cell transplantation in first c...
关键词：PATIENTS MYELOID LEUKEMIA 
Periostin^(+) myeloid cells improved long bone regeneration in a mechanosensitive manner
《Bone Research》2024年第4期895-911,共17页Ziyan Wang Minmin Lin Yonghao Pan Yang Liu Chengyu Yang Jianqun Wu Yan Wang Bingtong Yan Jingjing Zhou Rouxi Chen Chao Liu 
supported by grants from Shenzhen Science and Technology Innovation Commission (KQTD20200820113012029,JCYJ20190809114209434)。
Myeloid cells are pivotal in the inflammatory and remodeling phases of fracture repair.Here,we investigate the effect of periostin expressed by myeloid cells on bone regeneration in a monocortical tibial defect(MTD)mo...
关键词：MYELOID STIMULATION MEC 
Leukocyte immunoglobulin-like receptor B4(LILRB4)in acute myeloid leukemia:From prognostic biomarker to immunotherapeutic target
《Chinese Medical Journal》2024年第22期2697-2711,共15页Muzi Li Xiangyu Zhao 
supported by grants from National Natural Science Foundation of China(Nos.82350105,82270228,and 82070184);Science,Technology&Innovation Project of Xiongan New area(No.2023XACX0004);Beijing Nova Program(No.20220484235);Clinical Medicine Plus X-Young Scholars Project of Peking University,the Fundamental Research Funds for the Central Universities,Peking University People’s Hospital Research and Development Funds(No.RDL2021-01)。
Leukocyte immunoglobulin-like receptor(LILR)B4(also known as ILT3/CD85k)is an immune checkpoint protein that is highly expressed in solid tumors and hematological malignancies and plays a significant role in the patho...
关键词：LILRB4 Leukemia myeloid acute Immune checkpoint Tumor microenvironment Immunotherapy 
Neurokinin-2 receptor antagonist SR48968 induced necroptosis of myeloid leukemia cells by calcium overload-driven reactive oxygen species accumulation
《Genes & Diseases》2024年第5期33-35,共3页Zhibin Yan Xiangyu Hong Qihao Lin Leijie Wang Gang Shao Chentao Ge Ruilong Xia Caiyun Fu 
the Zhejiang Provincial Natural Science Foundation of China(No.LD22H310004);the“Pioneer”R&D program of Zhejiang,China(No.2022C03005);the National Natural Science Foundation of China(No.81770176,82204492);the Special Support Plan for Zhejiang Province High-Level Talents(China)(No.2019R52011).
Increasing evidence highlight tachykinin receptors as a prominent player in hematological malignancy.We previously revealed the proto-oncogenic role of neurokinin-1 receptor(NK-1R)in acute myeloid leukemia(AML),1 wher...
关键词：MYELOID ANTAGONIST markedly 
Dual inhibition of sirtuins 1 and 2:reprogramming metabolic energy dynamics in chronicmyeloid leukemia as an immunogenic anticancer strategy
《Cancer Communications》2024年第8期921-925,共5页Michael Schnekenburger Anne Lorant Sruthi Reddy Gajulapalli Ridhika Rajora Jin-Young Lee Aloran Mazumder Haeun Yang Christo Christov Hyoung Jin Kang Bernard Pirotte Marc Diederich 
LBMCC:“Recherche Cancer et Sang”foundation,the“Recherches Scientifiques Luxembourg”,the“Een Harz fir kriibskrank Kanner”,the Action LIONS“Vaincre le Cancer”and Télévie Luxembourg.SNU:National Research Foundation(NRF)(Grant Number 370C-20220063);MEST of Korea for Tumor Microenvironment Global Core Research Center(GCRC)(Grant Number 2011-0030001);Brain Korea(BK21)PLUS program and Creative-Pioneering Researchers Program at Seoul National University(Funding number:370C-20160062).Sruthi Reddy Gajulapalli and Ridhika Rajora were supported by grants for the“Graduate Scholarship for Excellent Foreign Students”program.
Chronicmyeloid leukemia(CML)is a lethal hematopoietic malignancy with a global incidence primarily attributed to the breakpoint cluster region-Abelson(BCR-ABL1)fusion oncogene in over 95%of cases.The introduction of t...
关键词：metabolism MYELOID alterations 
Identification of TMEM217 as a novel prognostic biomarker and potential therapeutic target in acute myeloid leukemia
《Genes & Diseases》2024年第4期90-93,共4页Yunying Yao Zhizhou Xi Min Wu Bo Jiao Jiaming Gao Donghe Li Xi Xie Pengfei Xu Jiaoyang Li Lei Yan Ruibao Ren Ping Liu 
supported by the Key Project of the National Natural Science Foundation of China(No.82230088 to R.R.);National Natural Science Foundation of China(No.81870112,82170147 to R.R.,No.81970134,82170111 to P.L.,No.82200200 to Z.X.);Shanghai Science and Technology Development Funds(China)(No.20Z11900200 to R.R.,No.18ZR1423600 to P.L);Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research(China)(No.2019CXJQ01 to R.R.);the Samuel Waxman Cancer Research Foundation(to R.R.);the Innovative Research Team of High-level Local Universities in Shanghai,China(to R.R.);the National Key Research and Development Program of China(No.2022YFC2705004 to P.L.).
Despite remarkable advances in molecular and cell biology of acute myeloid leukemia(AML),AML patients still frequently relapse and have low 5-year overall survival(OS)rates.1 It is worth noting that a recent study fro...
关键词：ACUTE MYELOID LEUKEMIA 
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