Single-cell analyses revealed key tumor-infiltrating myeloid cell subsets associated with clinical outcomes in different subtypes of breast cancer  

作　　者：Dingjie Wu Si Chen Yijin Liu Bowen Yang Ruixin Li Feng Jin Fan Yao Yue Fang 

机构地区：[1]Department of Microbial and Biochemical Pharmacy,School of Pharmacy,China Medical University,Shenyang,Liaoning 110122,China [2]Department of Breast Surgery and Surgical Oncology,Research Unit of General Surgery,The First Affiliated Hospital of China Medical University,Shenyang,Liaoning 110000,China [3]Department of Medical Oncology,The First Affiliated Hospital of China Medical University,Shenyang,Liaoning 110000,China

出　　处：《Genes & Diseases》2024年第6期32-35,共4页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China (No.81974418);Basic Research Project of Liaoning Province (No.JC2019002);Doctoral Start-up Foundation of Liaoning Province (No.2019-BS-284);Youth backbone Support Program of China Medical University (No.QGZ2018081).

摘　　要：Breast cancer is the most common cancer and the leading cause of cancer death in women worldwide.1 Tumor-infiltrating myeloid cells(TiMs),key components of tumor microenvironment,are considered to be potential therapeutic targets for cancer recently,2.3 however,their heterogeneity remains insufficiently characterized in different breast cancer subtypes.A more detailed TIM transcriptional atlas across breast cancer subtypes at the single-cell level is required to better understand the underlying mechanisms influencing the prognosis of breast cancer patients.

关 键 词：BREAST infiltrating MYELOID 

分 类 号：R73[医药卫生—肿瘤]