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Translational challenges in amyotrophic lateral sclerosis therapy with macrophage migration inhibitory factor: 《Neural Regeneration Research》2025年第9期2583-2584,共2页Leenor Alfahel Aleksandar Rajkovic Adrian Israelson; supported by grants from the Israel Science Foundation(ISF#284/19);German Israeli Foundation(GIF#I-116-415.6-2016)(to AI)。; Macrophage migration inhibitory factor(MIF):MIF acts as a pleiotropic inflammatory mediator,playing regulatory roles in innate and adaptive immunity,neuroinflammation,neuroendocrine functions,and nervous system develo...; 关键词：IMMUNITY SCLEROSIS

Cross-talk between lactate metabolism and immunity reveals CEP55 as a potential regulator in the immunosuppressive microenvironment of hepatocellular carcinoma: 《Genes & Diseases》2025年第3期42-45,共4页Jie Li Yuyuan Zhang Jinhai Deng Siyuan Weng Hui Xu Yuhao Ba Anning Zuo Shutong Liu Quan Cheng Jian Zhang Peng Luo Zhen Li Xinwei Han Zaoqu Liu; supported by the Major Science and Technology projects of Henan Province,China(No.221100310100).; The interaction of lactate metabolism with immunity plays a crucial role in the remodeling of the immune microenvironment and even in the heterogeneous progression of hepatocellular carcinoma(HCC).The intratumor-accum...; 关键词：cep hepatocellular carcinoma hepatocellular carcinoma hcc lactate metabolism IMMUNITY proliferation infiltration immunosuppressive cells remodeling immune microenvironment immunosuppressive microenvironment

Complete Protection Strategy for Loss of Excitation in Large-Scale Synchronous Condensers Applied to UHVDC Transmission: 《CSEE Journal of Power and Energy Systems》2025年第2期919-930,共12页Zhilin Guo Liangliang Hao Jinghan He Zhengguang Chen Xingguo Wang; Large-scale synchronous condenser (LSC) has a broad application prospect in China's ultra-high voltage direct current (UHVDC) to provide dynamic reactive power. Loss of excitation (LOE) is an important grid-related fa...; 关键词：Commutation failure immunity excitation current large-scale synchronous condenser loss of excitation protection UHVDC

Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression: 《Genes & Diseases》2025年第2期227-243,共17页Yulan Huangg Yuan Gao Zhenghong Lin Hongming Miao; supported in part by the National Natural Science Foundation of China (No.82173134);the Chongqing Fund for Outstanding Youth (China) (No.CSTB2022NSCO-JOX0010).; The tumor microenvironment is a complex environment comprising tumor cells,non-tumor cells,and other critical non-cellular components.Some studies about tumor micro-environment have recently achieved remarkable progre...; 关键词：Adipose cells DEUBIQUITINATION IMMUNITY Tumor microenvironment Tumor-associated fibroblasts UBIQUITINATION

To cleave or not and how?The DNA exonucleases and endonucleases in immunity: 《Genes & Diseases》2025年第2期244-254,共11页Mingjun Lu Jinghong Wu Qing Gao Renjing Jin Changming An Teng Ma; supported by the Beijing Xisike Clinical Oncology Research Foundation (China) (No.Y-HR2020MS-0156 to T.M.);the National Natural Science Foundation of China (No.82273130 to T.M.).; DNA exonucleases and endonucleases are key executors of the genome during many physiological processes.They generate double-stranded DNA by cleaving damaged endogenous or exogenous DNA,triggering the activation of the...; 关键词：cGAS-STING pathway DNA repair ENDONUCLEASES Exonucleases IMMUNITY

T helper 17 cells and interleukin-17 immunity in type 1 diabetes:From pathophysiology to targeted immunotherapies: 《World Journal of Diabetes》2025年第4期48-61,共14页Georgi Vasilev Maria Kokudeva Elina Siliogka Nathalia Padilla Russka Shumnalieva David Della-Morte Camillo Ricordi Antoaneta Mihova Marco Infante Tsvetelina Velikova; Supported by the European Union-NextGenerationEU,through the National Recovery and Resilience Plan of the Republic of Bulgaria,No.BG-RRP-2.004-0008.; Type 1 diabetes(T1D)is a chronic organ-specific autoimmune disorder characterized by a progressive loss of the insulin-secreting pancreatic beta cells,which ultimately results in insulinopenia,hyperglycemia and lifelo...; 关键词：Type 1 diabetes T helper 17 cells INTERLEUKIN-17 T helper 1 cells Regulatory T cells Anti-interleukin-17 treatment Th17-targeted treatment

Ce6-GFFY is a novel photosensitizer for colorectal cancer therapy: 《Genes & Diseases》2025年第2期304-318,共15页Wei Qiao Shuxin Li Linna Luo Meiling Chen Xiaobin Zheng Jiacong Ye Zhaohui Liang Qiaoli Wang Ting Hu Ling Zhou Jing Wang Xiaosong Ge Guokai Feng Fang Hu Rongbin Liu Jianjun Li Jie Yang; supported by grants from the National Natural Science Foundation of China (No.82373174,82002466,82202907).; Photodynamic therapy is an"old"strategy for cancer therapy featuring clinical safety and rapid working,but suitable photosensitizers for colorectal cancer therapy remain lacking.This study synthesized a novel photosen...; 关键词：Anti-tumorimmunity Ce6-GFFY Colorectal cancer Novel photosensitizer Photodynamic therapy

Autoinhibition and cofactors of a helper NLR: 《Science China(Life Sciences)》2025年第3期890-892,共3页Hongyuan Zheng Xuemin Zhou Chenyu Zhao Daowen Wang Zhengqing Fu; supported by the National Science Foundation(IOS-2207677);the key research and development grant from Henan Province(232102111078).; Plants offer a plethora of benefits to human existence.However,in the natural world,plants encounter numerous biotic and abiotic pressures,including the presence of various pathogens that cause serious diseases on cro...; 关键词：IMMUNITY DISEASES CROPS

Role of autophagy in rejection after solid organ transplantation:A systematic review of the literature: 《World Journal of Transplantation》2025年第3期79-90,共12页Shu-Min Jiang Xue-Jiao Li Zi-Lin Wang Zhi-Wei Chen Zhi-Long Liu Qiang Li Xiao-Long Chen; Supported by the National Natural Science Foundation of China,No.82100691;China Postdoctoral Science Foundation,No.2021M693631.; Organ transplantation has long been recognized as an effective treatment for endstage organ failure,metabolic diseases,and malignant tumors.However,graft rejection caused by major histocompatibility complex mismatch r...; 关键词：AUTOPHAGY Organ transplantation Graft rejection IMMUNITY Immune modulation

Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases被引量：2: 《Neural Regeneration Research》2025年第3期763-778,共16页Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao Qi Wang; supported by the National Natural Science Foundation of China, No.82274616;the Key Laboratory Project for General Universities in Guangdong Province, No.2019KSYS005;Guangdong Province Science and Technology Plan International Cooperation Project, No.2020A0505100052 (all to QW)。; Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain met...; 关键词：central nervous system meningeal lymphatic vessels IMMUNITY myeloid cells lymphatic cells neurodegenerative disease

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