Cross-talk between lactate metabolism and immunity reveals CEP55 as a potential regulator in the immunosuppressive microenvironment of hepatocellular carcinoma  

作　　者：Jie Li Yuyuan Zhang Jinhai Deng Siyuan Weng Hui Xu Yuhao Ba Anning Zuo Shutong Liu Quan Cheng Jian Zhang Peng Luo Zhen Li Xinwei Han Zaoqu Liu 

机构地区：[1]Department of Interventional Radiology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China [2]Interventional Institute of Zhengzhou University,Zhengzhou,Henan 450052,China [3]Interventional Treatment and Clinical Research Center of Henan Province,Zhengzhou,Henan 450052,China [4]Richard Dimbleby Laboratory of Cancer Research,School of Cancer&Pharmaceutical Sciences,King’s College London,London WC2R 2LS,UK [5]Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [6]Department of Oncology,Zhujiang Hospital,Southern Medical University,Guangzhou,Guangdong 519015,China [7]Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China

出　　处：《Genes & Diseases》2025年第3期42-45,共4页基因与疾病(英文)

基　　金：supported by the Major Science and Technology projects of Henan Province,China(No.221100310100).

摘　　要：The interaction of lactate metabolism with immunity plays a crucial role in the remodeling of the immune microenvironment and even in the heterogeneous progression of hepatocellular carcinoma(HCC).The intratumor-accumulated lactate served a vital role in the inefficacy of antitumor immune responses,the aggressiveness of tumor cells,and immunotherapy.1 Furthermore,lactate generated from the tumor microenvironment can be used as fuel for the proliferation and infiltration of immunosuppressive cells.2 Previous studies regarding the taxonomies of HCC,solely from the perspective of lactate3 or tumor immune microenvironment4 may introduce the potential for bias in the comprehension of HCC heterogeneity.Thus,deciphering the crosstalk properties between lactate and immune is imperative.

关 键 词：cep hepatocellular carcinoma hepatocellular carcinoma hcc lactate metabolism IMMUNITY proliferation infiltration immunosuppressive cells remodeling immune microenvironment immunosuppressive microenvironment 

分 类 号：R735.7[医药卫生—肿瘤]