ENDONUCLEASES

作品数:13被引量:20H指数:2
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To cleave or not and how?The DNA exonucleases and endonucleases in immunity
《Genes & Diseases》2025年第2期244-254,共11页Mingjun Lu Jinghong Wu Qing Gao Renjing Jin Changming An Teng Ma 
supported by the Beijing Xisike Clinical Oncology Research Foundation (China) (No.Y-HR2020MS-0156 to T.M.);the National Natural Science Foundation of China (No.82273130 to T.M.).
DNA exonucleases and endonucleases are key executors of the genome during many physiological processes.They generate double-stranded DNA by cleaving damaged endogenous or exogenous DNA,triggering the activation of the...
关键词:cGAS-STING pathway DNA repair ENDONUCLEASES Exonucleases IMMUNITY 
CRISPR beyond:harnessing compact RNA-guided endonucleases for enhanced genome editing
《Science China(Life Sciences)》2024年第12期2563-2574,共12页Feizuo Wang Shengsheng Ma Senfeng Zhang Quanquan Ji Chunyi Hu 
The CRISPR-Cas system,an adaptive immunity system in prokaryotes designed to combat phages and foreign nucleic acids,has evolved into a groundbreaking technology enabling gene knockout,large-scale gene insertion,base ...
关键词:CRISPR-Cas OMEGA(ω)system TRANSPOSASE gene-editing compact editors protein engineering miniature Cas effector 
CORRECTION:Author Correction:Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs
《Cell Research》2024年第11期814-814,共1页
Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs被引量:2
《Cell Research》2024年第5期370-385,共16页Kuan Ren Fengxia Zhou Fan Zhang Mingyu Yin Yuwei Zhu Shouyu Wang Yan Chen Tengjin Huang Zixuan Wu Jiale He Anqi Zhang Changyou Guo Zhiwei Huang 
the National Key R&D Program of China(2023YFF1000200);the National Natural Science Foundation of China(31825008 and U21A20276);the Tencent Foundation through the XPLORER PRIZE and the New Cornerstone Science Foundation to Z.H.,and Heilongjiang Touyan Team(HITTY-20190034 to Z.H.).
CRISPR-Cas systems and IS200/IS605 transposon-associated TnpBs have been utilized for the development of genome editing technologies.Using bioinformatics analysis and biochemical experiments,here we present a new fami...
关键词:GUIDED STRUCTURAL utilized 
Efficient scar-free knock-ins of several kilobases in plants by engineered CRISPR-Cas endonucleases
《Molecular Plant》2024年第5期824-837,共14页Tom Schreiber Anja Prange Petra Schafer Thomas Iwen Ramona Grutzner Sylvestre Marillonnet Aurelie Lepage Marie Javelle Wyatt Paul Alain Tissier 
funded by grant no.031B0548 in the frame of the program"Crop plants of the future"from the Bundesministerium fur Bildung und Forschung to A.T.;funded by the Investissement d’Avenir program of the French National Agency of Research for the project GENIUS(ANR-11-BTBR-0001_GENIUS).
In plants and mammals,non-homologous end-joining is the dominant pathway to repair DNA doublestrand breaks,making it challenging to generate knock-in events.In this study,we identified two groups of exonucleases from ...
关键词:homology-directed repair knockin gene replacement CRISPR-Cas 50 exonuclease PLANTS 
Fanzors: Striking expansion of RNA-guided endonucleases to eukaryotes
《Cell Research》2024年第2期99-100,共2页Hui Yang Dinshaw J.Patel 
RNA-guided DNA endonucleases are broadly associated with and play critical roles in prokaryotic adaptive immunity-based CRISPR-Cas systems and IS200/605 family transposons.The Feng Zhang lab recently elucidated the ph...
关键词:PHYLOGENY mechanism thereby 
The development and application of genome editing technology in ruminants: a review被引量:1
《Frontiers of Agricultural Science and Engineering》2020年第2期171-180,共10页Mengke YUAN Yuanpeng GAO Jing HAN Teng WU Jingcheng ZHANG Yongke WEI Yong ZHANG 
supported by the National Major Project for Production of Transgenic Breeding(2016ZX08007003)。
Transgenic ruminants are a valuable resource for both animal breeding and biomedical research.The development of transgenic breeding is proceeding slowly,because it suffers from low efficiency of gene transfer and pos...
关键词:bioreactors BREEDING engineered endonucleases genome editing RUMINANTS 
CRISPR-Cas System for RNA Detection and Imaging被引量:1
《Chemical Research in Chinese Universities》2020年第2期157-163,共7页CHEN Siyu WANG Rujia LEI Chunvang NIE Zhou 
Supported by the National Natural Science Foundation of China(Nos.21725503,21575038);the Young Top-notch Talent for Ten Thousand Talent Program of China.
The system of clustered regularly interspaced short palindromic repeats(CRISPR)and CRISPR-associated endonucleases(Cas)have been widely used in gene editing,disease treatment,molecular diagnosis and chromosome imaging...
关键词:Clustered regularly interspaced short palindromic repeats-associated endonucleases(CRISPR-Cas) RNA detection RNA IMAGING COLLATERAL cleavage 
Advances in homology directed genetic engineering of human pluripotent and adult stem cells
《World Journal of Stem Cells》2013年第4期98-105,共8页Kalpith Ramamoorthi Donald Curtis Prashanth Asuri 
The ability to introduce precise genomic modifications in human cells has profound implications for both basic and applied research in stem cells, ranging from identification of genes regulating stem cell self-renewal...
关键词:HUMAN stem cells GENETIC engineering Engineered viruses Synthetic RESTRICTION ENDONUCLEASES 
Inhibition of DNA restrictive endonucleases by aqueous nanoparticle suspension of methanophosphonate fullerene derivatives and its mechanisms
《Science China Chemistry》2009年第5期626-631,共6页SONG GaoGuang YAO Lu HUANG Cheng XIE Xin TAN Xin YANG XinLin 
Supported by the National Natural Science Foundation of China (Grant No. 20672012);Beijing Natural Science Foundation (Grant No. 20822020)
Aqueous nanoparticle suspension of fullerene and its derivatives are currently attracting much attention. To determine the effects of aqueous nanoparticle suspension of a mono-methanophosphonate fullerene and bis-meth...
关键词:mono-and bis-methanophosphonate FULLERENE AQUEOUS nanoparticle suspension DNA RESTRICTIVE ENDONUCLEASES reactive oxygen species 
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