Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression  

作　　者：Yulan Huangg Yuan Gao Zhenghong Lin Hongming Miao 

机构地区：[1]Department of Pathophysiology,College of High Altitude Military Medicine,Army Medical University,Chongqing 400038,China [2]School of Life Sciences,Chongqing University,Chongqing 401331,China [3]Jinfeng Laboratory,Chongqing 401329,China

出　　处：《Genes & Diseases》2025年第2期227-243,共17页基因与疾病(英文)

基　　金：supported in part by the National Natural Science Foundation of China (No.82173134);the Chongqing Fund for Outstanding Youth (China) (No.CSTB2022NSCO-JOX0010).

摘　　要：The tumor microenvironment is a complex environment comprising tumor cells,non-tumor cells,and other critical non-cellular components.Some studies about tumor micro-environment have recently achieved remarkable progress in tumor treatment.As a substantial part of post-translational protein modification,ubiquitination is a crucial player in maintaining protein stability in cell signaling,cell growth,and a series of cellular life activities,which are also essential for regulating tumor cells or other non-tumor cells in the tumor microenviron-ment.This review focuses on the role and function of ubiquitination and deubiquitination modification in the tumor microenvironment while discussing the prospect of developing inhib-itors targeting ubiquity-related enzymes,thereby providing ideas for future research in cancer therapy.

关 键 词：Adipose cells DEUBIQUITINATION IMMUNITY Tumor microenvironment Tumor-associated fibroblasts UBIQUITINATION 

分 类 号：R73[医药卫生—肿瘤]