UBIQUITINATION

作品数：297被引量：941H指数：13
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相关机构：山东大学北京大学中国科学院清华大学更多>>
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Key roles of ubiquitination in regulating critical regulators of cancer stem cell functionality
《Genes & Diseases》2025年第3期219-252,共34页Qianqian Guo Hai Qin Zelong Chen Wenzhou Zhang Lufeng Zheng Tingting Qin 
supported by grants from The National Nature Science Foundation of China(No.82173842);WU JIEPING Medical Foundation(No.320.6750.2023-05-7);The Medical Science and Technology Research Project of Henan Province,China(No.SBGJ202003010).
The ubiquitin (Ub) system, a ubiquitous presence across eukaryotes, plays a crucialrole in the precise orchestration of diverse cellular protein processes. From steering cellularsignaling pathways and orchestrating ce...
关键词：Cancer progression Cancer stem cell E3 ubiquitin ligase Signalingtransduction UBIQUITIN 
Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression
《Genes & Diseases》2025年第2期227-243,共17页Yulan Huangg Yuan Gao Zhenghong Lin Hongming Miao 
supported in part by the National Natural Science Foundation of China (No.82173134);the Chongqing Fund for Outstanding Youth (China) (No.CSTB2022NSCO-JOX0010).
The tumor microenvironment is a complex environment comprising tumor cells,non-tumor cells,and other critical non-cellular components.Some studies about tumor micro-environment have recently achieved remarkable progre...
关键词：Adipose cells DEUBIQUITINATION IMMUNITY Tumor microenvironment Tumor-associated fibroblasts UBIQUITINATION 
Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop
《Acta Pharmacologica Sinica》2025年第3期592-605,共14页Shu-ting Yu Zhi-yong Sun Na Li Zhe-zhe Qu Chang-hao Wang Tian-tian Ju Ying-qi Liu Zhong-ting Mei Kui-wu Liu Mei-xi Lu Min Huang Ying Li Shun-kang Dou Jian-hao Jiang Yao-zhi Zhang Chuan-hao Huang Xiao-chen Pang Ying-qiong Jia Xian-hui Dong Fan Wu Yi Zhang Wan-hong Li Bao-feng Yang Wei-jie Du 
supported by grants from the National Natural Science Foundation of China(82273928,82473919,82330011,U21A20339);Natural Science Foundation for Distinguished Young Scholars of Heilongjiang Province(2024JQ0107);Youth Project of Scientific Research Institution of Heilongjiang Province(CZKYF2023-1-C047);CAMS Innovation Fund for Medical Sciences(CIFMS,2020-I2M-5-003).
The N7-methylguanosine(m7G)methyltransferase Mettl1 has been recently implicated in cardiac repair and fibrosis.In this study we investigated the role of Mettl1 in mouse cardiomyocytes injury and the underlying mechan...
关键词：cardiac ischemia/reperfusion injury Mettl1 m7G CYLD P53 UBIQUITINATION 
Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptorα
《Genes & Diseases》2025年第1期312-326,共15页Guangfei Li Aifei Wang Wei Tang Wenyu Fu Qingyun Tian Jinlong Jian Michal Lata Aubryanna Hettinghouse Yuanjing Ding Jianlu Wei Xiangli Zhao Mingyong Wang Qirong Dong Chuanju Liu Youjia Xu 
supported by the grants from China Scholarship Council(No.201505320002);the National Institutes of Health(No.R01AR062207,R01AR061484,R01AR076900,R01NS103931);Young Medical Talents Program of Jiangsu Province,China(No.QNRC2016878);National Key R&D Program of China(No.SQ2021YFC2501702);Natural Science Foundation of China(No.82072474);Clinical Medicine Technology Project of Jiangsu Province,China(No.BE2019661).
Estrogen deficiency is considered the most important cause of postmenopausal osteoporosis.However,the underlying mechanism is still not completely understood.In this study,progranulin(PGRN)was isolated as a key regula...
关键词：Estrogen receptorα OSTEOCLASTOGENESIS Postmenopausal osteoporosis Progranulin UBIQUITINATION 
Improving regulatory T cell-based therapy:insights into post-translational modification regulation
《Journal of Genetics and Genomics》2025年第2期145-156,共12页Aiting Wang Yanwen Wang Rui Liang Bin Li Fan Pan 
supported by grants from the National Key R&D Program of China(2022YFC2403000 and 2021YFC2400500);the National Natural Science Foundation of China(32200728 and 32170925);the Clinical Research Project of Shenzhen Medical Academy of Research and Translation(C2301008);Shenzhen Science and Technology Program(JCYJ20220531100406014,JCYJ2022081800807016,RCBS20221008093336088,KQTD20210811090115019);Guangdong Basic and Applied Basic Research Foundation(2021A1515110375);the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20210601).
Regulatory T(Treg)cells are pivotal for maintaining immune homeostasis and play essential roles in various diseases,such as autoimmune diseases,graft-versus-host disease(GVHD),tumors,and infectious diseases.Treg cells...
关键词：Treg cell FOXP3 UBIQUITINATION ACETYLATION PHOSPHORYLATION METHYLATION GLYCOSYLATION Post-translational modification 
E3 Ligases and COVID-19:Insights into Viral Control andTherapeutic Potential
《BIOCELL》2025年第1期127-147,共21页Mukul Mishra Deeba Khan Sehbanul Islam 
The COVID-19 pandemic,caused by the newly emerged coronavirus SARS-CoV-2,has resulted in unprecedented global health challenges,including millions of infections and deaths.While the direct effects of the virus are cri...
关键词：SARS-CoV-2 COVID-19 viral proteins host-pathogen interaction E3 ubiquitin ligases UBIQUITINATION targeted protein degradation 
Drosophila Cul3 contributes to Diap2-mediated innate immune signaling for antimicrobial defense
《hLife》2025年第1期38-51,共14页Fanrui Kong Zixuan Wang Chuchu Zhang Yihua Xiao Muhammad Abdul Rehman Saeed Weini Li Akira Goto Qingshuang Cai Shanming Ji 
supported by grants from the National Natural Science Foundation of China(32100702).
The host antimicrobial immune response relies on a complex interplay of molecular mechanisms to effectively combat microbial infections.Herein,we investigate the functional role of Cullin-3(Cul3),one critical constitu...
关键词：Cullin-3(Cul3) death-associated inhibitor of apoptosis 2(Diap2) death-related ced-3/Nedd2-like caspase(Dredd)ubiquitination antimicrobial immune defense Drosophila melanogaster 
Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate aging in mice
《Protein & Cell》2025年第1期28-48,共21页Sipeng Wu Yiqi Cai Lixiao Zhang Xiang Li Xu Liu Guangkeng Zhou Hongdi Luo Renjian Li Yujia Huo Zhirong Zhang Siyi Chen Jinliang Huang Jiahao Shi Shanwei Ding Zhe Sun Zizhuo Zhou Pengcheng Wang Geng Wang 
supported by the Priority Research Program of the Ministry of Science and Technology of the People’s Republic of China(Grant Nos.2017YFA0504600);the National Natural Science Foundation of the People’s Republic of China(Grants Nos.91649103,32091159).
One of the basic questions in the aging field is whether there is a fundamental difference between the aging of lower invertebrates and mammals.A major difference between the lower invertebrates and mammals is the abu...
关键词：TERC-53 mitochondrial noncoding RNAs brain aging NEUROINFLAMMATION UBIQUITINATION 
Ubiquitination in diabetes and its complications:A perspective from bibliometrics
《World Journal of Diabetes》2025年第1期187-203,共17页Li-Yuan Xiong Wei Zhao Fa-Quan Hu Xue-Mei Zhou Yu-Jiao Zheng 
Supported by Key Project of Anhui Provincial Education Department,No.2022AH050486;and 2021 High-level Talent Introduction Scientific Project of Anhui University of Chinese Medicine,No.2022rczd005.
BACKGROUND Diabetes has a substantial impact on public health,highlighting the need for novel treatments.Ubiquitination,an intracellular protein modification process,is emerging as a promising strategy for regulating ...
关键词：Diabetes mellitus UBIQUITINATION Bibliometric analysis CiteSpace Research trends 
ALFIN-like proteins link histone H3K4me3 to H2A ubiquitination and coordinate diverse chromatin modifications in Arabidopsis
《Molecular Plant》2025年第1期130-150,共21页Xiao-Min Su Dan-Yang Yuan Na Liu Zhao-Chen Zhang Minqi Yang Lin Li She Chen Yue Zhou Xin-Jian He 
supported by the National Natural Science Foundation of China to X.-J.H.(grant numbers 32025003 and 32470628).
Trimethylation of histone H3K4(H3K4me3)is widely distributed at numerous actively transcribed protein-coding genes throughout the genome.However,the interplay between H3K4me3 and other chromatin modifications in plant...
关键词：ALFIN-like proteins PRC1 HISTONE H3K4me3 H2Aub H2A.Z 
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