OSTEOCLASTOGENESIS

作品数：73被引量：220H指数：8
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相关领域：医药卫生更多>>
相关作者：王宇琛李建磊韩维奇徐璐璐杨万雷更多>>
相关机构：山东大学广西医科大学北京大学绍兴市人民医院更多>>
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Fat mass and obesity-associated protein in mesenchymal stem cells inhibits osteoclastogenesis via lnc NORAD/miR-4284 axis in ankylosing spondylitis
《World Journal of Stem Cells》2025年第3期28-43,共16页Wen-Jie Liu Jia-Xin Wang Quan-Feng Li Yun-Hui Zhang Peng-Fei Ji Jia-Hao Jin Yi-Bin Zhang Zi-Hao Yuan Pei Feng Yan-Feng Wu Hui-Yong Shen Peng Wang 
Supported by Guangdong Provincial Clinical Research Center for Orthopedic Diseases,No.2023B110001;the Excellent Medical Innovation Talent Program of the Eighth Affiliated Hospital of Sun Yat-sen University,No.YXYXCXRC202101;the National Natural Science Foundation of China,No.82172349,No.82372372,No.22105229,No.32170708,No.82102530,No.82102541,No.82103098,No.82103909,No.82104182,No.82104350,No.82170427,No.82171291,No.82172215,No.82172385,and No.82302661;Guangdong Natural Science Foundation,No.2023A1515010568 and No.2021A1515111057;Shenzhen Science and Technology Program,No.JCYJ20220530144201004 and No.RCBS20210609104445097;and Futian Healthcare Research Project,No.FTWS2022022,No.FTWS2021013,No.FTWS2023072,and No.FTWS2022047.
BACKGROUND Ankylosing spondylitis(AS)is recognized as a long-term inflammatory disorder that leads to inflammation in the spine and joints,alongside abnormal bone growth.In previous studies,we reported that mesenchyma...
关键词：Ankylosing spondylitis Mesenchymal stem cells OSTEOCLASTOGENESIS Fat mass and obesity-associated protein Non-coding RNA activated by DNA damage 
Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptorα
《Genes & Diseases》2025年第1期312-326,共15页Guangfei Li Aifei Wang Wei Tang Wenyu Fu Qingyun Tian Jinlong Jian Michal Lata Aubryanna Hettinghouse Yuanjing Ding Jianlu Wei Xiangli Zhao Mingyong Wang Qirong Dong Chuanju Liu Youjia Xu 
supported by the grants from China Scholarship Council(No.201505320002);the National Institutes of Health(No.R01AR062207,R01AR061484,R01AR076900,R01NS103931);Young Medical Talents Program of Jiangsu Province,China(No.QNRC2016878);National Key R&D Program of China(No.SQ2021YFC2501702);Natural Science Foundation of China(No.82072474);Clinical Medicine Technology Project of Jiangsu Province,China(No.BE2019661).
Estrogen deficiency is considered the most important cause of postmenopausal osteoporosis.However,the underlying mechanism is still not completely understood.In this study,progranulin(PGRN)was isolated as a key regula...
关键词：Estrogen receptorα OSTEOCLASTOGENESIS Postmenopausal osteoporosis Progranulin UBIQUITINATION 
Buqi-Tongluo Decoction inhibits osteoclastogenesis and alleviates bone loss in ovariectomized rats by attenuating NFATc1,MAPK,NF-κB signaling
《Chinese Journal of Natural Medicines》2025年第1期90-101,共12页Yongxian Li Jinbo Yuan Wei Deng Haishan Li Yuewei Lin Jiamin Yang Kai Chen Heng Qiu Ziyi Wang Vincent Kuek Dongping Wang Zhen Zhang Bin Mai Yang Shao PanKang Qiuli Qin Jinglan Li Huizhi Guo Yanhuai Ma Danqing Guo Guoye Mo YijingFang Renxiang Tan Chenguang Zhan Teng Liu Guoning Gu Kai Yuan Yongchao Tang DeLiang Liangliang Xu Jiake Xu Shuncong Zhang 
supported by the Natural Science Foundation of Guangdong Province,China(No.2021A1515012168);the Administration of Traditional Chinese Medicine of Guangdong Province,China(Nos.20221146 and 20241091);the Basic and Applied Basic Research Fund Project in Guangdong Province,China(No.2020A1515110948);the Basic and Applied Basic Research in Jointly Funded Projects of City Schools(Institutes)Projects,China(Nos.202201020500 and 202201020295);the Project of Guangzhou Science and Technology Department,China(No.202102021040);the Guangzhou Science and Technology Plan Project,China(No.2023B03J0379);the Chinese Society of Traditional Chinese Medicine Youth Talent Lifting Project(No.2022-QNRC2-B11);the Hospital Young and Middle-aged Key Talent Cultivation Project of The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine(2023-10)。
Osteoporosis is a prevalent skeletal condition characterized by reduced bone mass and strength,leading to increased fragility.Buqi-Tongluo(BQTL)decoction,a traditional Chinese medicine(TCM)prescription,has yet to be f...
关键词：OSTEOPOROSIS Estrogen deficiency OSTEOCLAST Buqi-Tongluo NFATc1 MAPK NF-ΚB 
Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation
《Engineered Regeneration》2024年第4期482-494,共13页Guang Yang Zili Guo Xiangfeng Zhang Jiayu Chen Jie Weng Jiapeng Bao Xiaohua Yu 
supported by the National Natural Science Foundation of China(Grant No.82372381,52071277);the National Natural Science Foundation of Zhejiang Province(Grant No.LY23H060013).
Repair of large bone defects remains to be clinically challenging,yet current bone repair strategies focus on optimizing the osteogenic capacity of bone grafts,while the role of osteoclasts in bone regeneration has be...
关键词：Bone regeneration DENOSUMAB OSTEOCLASTOGENESIS OSTEOGENESIS 
Mapping RANKL-and OPG-expressing cells in bone tissue:the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect
《Bone Research》2024年第4期912-932,共21页Bilal M.El-Masri Christina M.Andreasen Kaja S.Laursen Viktoria B.Kofod Xenia G.Dahl Malene H.Nielsen Jesper S.Thomsen Annemarie Bruel Mads S.Sorensen Lars J.Hansen Albert S.Kim Victoria E.Taylor Caitlyn Massarotti Michelle M.McDonald Xiaomeng You Julia F.Charles Jean-Marie Delaisse Thomas L.Andersen 
supported by Odense University Hospital’s Fund for Free Research (A5111);the Region of Southern Denmark’s Fund for Free Research (A955);the VELUX Foundations (VELUX25723);supported by the Novo Nordisk Foundation。
Denosumab is a monoclonal anti-RANKL antibody that inhibits bone resorption,increases bone mass,and reduces fracture risk.Denosumab discontinuation causes an extensive wave of rebound resorption,but the cellular mecha...
关键词：RANKL MAPPING OPG 
Phenylboronic-tannin nanocolloids that scavenge subchondral reactive oxygen microenvironment and inhibit RANKL induced osteoclastogenesis for osteoarthritis treatment
《Nano Research》2024年第11期9898-9907,共10页Xiaoqun Li Yufang Kou Jia Jia Minchao Liu Runze Gao Yuhong Li Gang Li Shuogui Xu Wei Song Yang Xie Xiaomin Li Tiancong Zhao 
supported by the National Natural Science Foundation of China(Nos.22305042(Tiancong Zhao),22075049(Xiaomin Li),21875043(Xiaomin Li),82201748(Xiaomin Li));the Fundamental Research Funds for the Central Universities(No.20720220010(Xiaomin Li));the Natural Science Foundation of Shanghai(No.22ZR1478900(Xiaomin Li));the Shanghai Rising-Star Program(Nos.20QA1401200(Xiaomin Li),22YF1402200(Tiancong Zhao),21YF1459200(Xiaomin Li));Shanghai Pilot Program for Basic Research-Fudan University(No.22TQ004);Young Elite Scientist Sponsorship Program by Chinese Chemical Society(Tiancong Zhao),Xiaomi Young Talents Program(Tiancong Zhao),Qatar Research Development and Innovation Council(No.ARG01-0602-230467).
The excessive reactive oxygen species (ROS) accumulation and overactivated osteoclastogenesis in subchondral bone has proved to be a major cause of osteoarthritis (OA). Scavenging of ROS microenvironment to inhibit th...
关键词：POLYPHENOL nanoparticle reactive oxygen species(ROS) OSTEOCLASTOGENESIS subchondral bone 
Suppression of NFATc1 through NF-kB/PI3K signaling pathway by Oleandrin to inhibit osteoclastogenesis and bone resorption
《Engineered Regeneration》2024年第3期342-349,共8页Zhikun Li Kai Chen Qifeng Yu Yifan Li Shichao Tong Ruijun Xu Ruixi Hu Yi Zhang Wei Xu 
National Natural Science Foundation of China(82272165);Shanghai Municipal Commission of Health and Family Planning’s Science and Research Fund(202040141);Shanghai Municipality Science and Technology Commission(20ZR1451800,22ZR1457200);Shanghai Municipal Health Commission(2022YQ006);Shanghai Tongren Hospital(TRKYRC-xx202203).
Inflammation can initiate osteolysis,which is the breakdown of bone by fully developed osteoclasts.The com-pound Oleandrin is recognized for its effects against inflammation and tumors.Our objective was to examine the...
关键词：OSTEOCLASTOGENESIS OSTEOLYSIS NF-κB PI3K Oleandrin NFATc1 
机械敏感蛋白PC1调控破骨细胞及骨吸收的作用机制被引量：2
《Science Bulletin》2024年第12期1964-1979,共16页黄梅 周静璇 李潇骁 刘冉 姜洋子 陈开璇 焦玉睿 尹欣 刘玲 孙宇晨 王维山 肖业 苏甜 郭奇 黄燕 杨觅 魏婕 L.Darryl Quarles 肖洲生 曾超 罗湘杭 雷光华 李长俊 
supported by the National Key Research and Development Program of China(2019YFA0111900,2022YFC3601900 and 2022YFC2505500);the National Natural Science Foundation of China(82261160397,82272560,81922017,92149306 and 82120108009);the NSFC/RGC Joint Research Scheme;the Research Grants Council(UGC)of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China(N_CUHK483/22);the Center for Neuromusculoskeletal Restorative Medicine by Innovation and Technology Commission(ITC)of Hong Kong SAR,China(CNRM at Inno HK),the National Institutes of Health(R61-AR073518 and R01-AR071930);the Key Research and Development Program of Hunan Province(2022SK2023);the Science and Technology Innovation Program of Hunan Province(2023RC1027,2022RC1009 and 2022RC3075);the Hunan Provincial Science and Technology Department(2023JJ30896)。
Mechanical loading is required for bone homeostasis,but the underlying mechanism is still unclear.Our previous studies revealed that the mechanical protein polycystin-1(PC1,encoded by Pkd1)is critical for bone formati...
关键词：Polycystin1 OSTEOCLASTOGENESIS Bone resorption Mechanical stress 
Sirt5 desuccinylates Cdc42 to mediate osteoclastogenesis and bone remodeling in mice
《Genes & Diseases》2024年第3期75-78,共4页Yuang Zhanngg Jing Wang Jing Luan Chuanju Liu Yazhou Cui Jinxiang Han 
supported by the Academic Promotion Programme of Shandong First Medical University(China)(No.2019LJ001);the National Natural Science Foundation of China(No.81772300,82101903);The Innovation Project of Shandong Academy of Medical Sciences,Shandong,China。
Post-translational modifications(PTMs)play a critical role in bone remodeling,with phosphorylation and acetylation being particularly well characterized.Recently,succinylation,a relatively uncommon PTM on lysine,has r...
关键词：REMODELING ORGANS media 
Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis被引量：2
《Acta Pharmacologica Sinica》2024年第4期790-802,共13页Zong-bao Ding Yan Chen Yu-rong Zheng Yi-yuan Wang Wen-de Deng Jie-huang Zheng Qin Yang Zi-ye Chen Li-hong Li Hui Jiang Xiao-juan Li 
supported by the National Natural Science Foundation of China(82173825,81773740,and 81972064);the Science and Technology Plan Project of Guangzhou City(201804010027).
Osteoporosis results from overactivation of osteoclasts. There are currently few drug options for treatment of this disease. Since the successful development of allosteric inhibitors, phosphatases have become attracti...
关键词：OSTEOPOROSIS PPP1R15A Sephin1 OSTEOCLASTOGENESIS RANKL EIF2Α 
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