DENOSUMAB

作品数：75被引量：140H指数：6
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相关机构：北京积水潭医院北京大学华中科技大学同济医学院附属协和医院四川大学华西医院更多>>
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Denosumab combined with immunotherapy,radiotherapy,and granulocyte-macrophage colony-stimulating factor for the treatment of metastatic nasopharyngeal carcinoma:A case report
《World Journal of Clinical Oncology》2025年第2期130-143,共14页Wei-Wu Chen Yue-Hong Kong Li-Yuan Zhang 
Supported by The Suzhou Medical Center,No.Szlcyxzx202103;The National Natural Science Foundation of China,No.82171828;The Key R and D Plan of Jiangsu Province(Development of Social),No.BE2021652;The Subject Construction Support Project of The Second Affiliated Hospital of Soochow University,No.XKTJHRC20210011;The Wu Jieping Medical Foundation,No.320.6750.2021-01-12;The Special Project of"Technological Innovation"Project of CNNC Medical Industry Co.Ltd,No.ZHYLTD2021001;The Suzhou Science and Education Health Project,No.KJXW2021018;Foundation of Chinese Society of Clinical Oncology,No.Y-pierrefabre202102-0113 and No.Y-XD202002/zb-0015;The Beijing Bethune Charitable Foundation,No.STLKY0016;The Research Projects of China Baoyuan Investment Co.Ltd,No.270004;The Suzhou Gusu Health Talent Program,No.GSWS2022028;The Open Project of State Key Laboratory of Radiation Medicine and Protection of Soochow University,No.GZN1202302;The New Medical Technology Project of the Second Affiliated Hospital of Soochow University,No.23zl001;The Multi-center Clinical Research Project for Major Diseases in Suzhou,No.DZXYJ202304;The Postgraduate Research and Practice Innovation Program of Jiangsu Province,No.SJCX24_1814;The Gusu Health Talent Research Fund,No.GSWS2022053;The National Natural Science Foundation of China,No.82102824;The Scientific Research Program for Young Talents of China National Nuclear Corporation。
BACKGROUND Bone is a major site of metastasis in nasopharyngeal carcinoma(NPC).Recently,nuclear factor kappa-beta ligand(RANKL)inhibitors have garnered attention for their ability to inhibit osteoclast formation and b...
关键词：Nasopharyngeal carcinoma Bone metastasis RADIOTHERAPY Programmed cell death protein 1 inhibitors DENOSUMAB Case report 
Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation
《Engineered Regeneration》2024年第4期482-494,共13页Guang Yang Zili Guo Xiangfeng Zhang Jiayu Chen Jie Weng Jiapeng Bao Xiaohua Yu 
supported by the National Natural Science Foundation of China(Grant No.82372381,52071277);the National Natural Science Foundation of Zhejiang Province(Grant No.LY23H060013).
Repair of large bone defects remains to be clinically challenging,yet current bone repair strategies focus on optimizing the osteogenic capacity of bone grafts,while the role of osteoclasts in bone regeneration has be...
关键词：Bone regeneration DENOSUMAB OSTEOCLASTOGENESIS OSTEOGENESIS 
Mapping RANKL-and OPG-expressing cells in bone tissue:the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect
《Bone Research》2024年第4期912-932,共21页Bilal M.El-Masri Christina M.Andreasen Kaja S.Laursen Viktoria B.Kofod Xenia G.Dahl Malene H.Nielsen Jesper S.Thomsen Annemarie Bruel Mads S.Sorensen Lars J.Hansen Albert S.Kim Victoria E.Taylor Caitlyn Massarotti Michelle M.McDonald Xiaomeng You Julia F.Charles Jean-Marie Delaisse Thomas L.Andersen 
supported by Odense University Hospital’s Fund for Free Research (A5111);the Region of Southern Denmark’s Fund for Free Research (A955);the VELUX Foundations (VELUX25723);supported by the Novo Nordisk Foundation。
Denosumab is a monoclonal anti-RANKL antibody that inhibits bone resorption,increases bone mass,and reduces fracture risk.Denosumab discontinuation causes an extensive wave of rebound resorption,but the cellular mecha...
关键词：RANKL MAPPING OPG 
Three cases of uncommon medication-associated osteonecrosis of temporal bone
《World Journal of Otorhinolaryngology-Head and Neck Surgery》2024年第3期237-240,共4页Hunter VanDolah Jason R.Crossley H.Jeffrey Kim 
Introduction:Medication-related osteonecrosis of the temporal bone is rare and has been reported to be associated with the use of anti-resorptive and biologic agents.Here,we present the first case of tyrosine-kinase i...
关键词：BISPHOSPHONATES DENOSUMAB external auditory canal imatinib medication-related osteonecrosis OSTEONECROSIS temporal bone tyrosine-kinase Inhibitors 
Thoracic giant cell tumor after two total en bloc spondylectomies including one emergency surgery:A case report
《World Journal of Clinical Cases》2024年第16期2894-2903,共10页Hai-Feng Liang Hao Xu Meng-Na Zhan Jian Xiao Juan Li Qin-Ming Fei 
Supported by The Shanghai Municipal Health Commission Clinical Research Project,No.202140140.
BACKGROUND For patients with acute paraplegia caused by spinal giant cell tumor(GCT)who require emergency decompressive surgery,there is still a lack of relevant reports on surgical options.This study is the first to ...
关键词：Giant cell tumor Thoracic spine Emergency treatment Total en bloc spondylectomy Denosumab therapy Case report 
Incidence and predictors of hypocalcemia in end-stage renal disease patients on denosumab therapy: A systematic review and metaanalysis
《World Journal of Meta-Analysis》2024年第3期68-78,共11页Abdul Hannan Siddiqui Misbah Shaikh Afia Salman Muhammad Ahmed Ali Fahim Fizzah Batool Tahreem Mari Sarah Musani Muneeb Fareed Rooma Rehan Amna Hassni Urooj Nizami Ayesha Amir Abdul Moeed Salim R Surani 
BACKGROUND Denosumab inhibits the receptor activator of nuclear factor kappa-ligand.It markedly increases bone mineral density and has been proven to reduce the risk of fractures.However,numerous adverse effects,notab...
关键词：DENOSUMAB End-stage renal disease HYPOCALCEMIA Parathyroid hormone DIALYSIS 
Calcitriol induced hypercalcemia-a rare phenomenon in lung cancer:A case report
《World Journal of Clinical Oncology》2023年第11期544-548,共5页Amulya Prakash Farhan Khalid Ahmad Alalwan Husam Bader Doantrang Du Trishala Meghal 
BACKGROUND Calcitriol-induced hypercalcemia has been rarely reported in cases of lung cancer;however,it is frequently reported in cases of lymphoid malignancy and granulomatous disease.We present a rare case of hyperc...
关键词：Hypercalcemia associated malignancy Lung cancer DENOSUMAB CALCITRIOL Vitamin D Case report 
Efficacy and safety of different anti-osteoporotic drugs for the spinal fusion surgery: A network meta-analysis被引量：1
《World Journal of Clinical Cases》2023年第30期7350-7362,共13页Xiao-Yuan He Huan-Xiong Chen Zhi-Rong Zhao 
BACKGROUND Administering anti-osteoporotic agents to patients perioperatively is a widely accepted approach for improving bone fusion rates and reducing the risk of complications.The best anti-osteoporotic agents for ...
关键词：Anti-osteoporotic agents Spinal fusion procedure Network meta-analysis Systematic review DENOSUMAB 
地舒单抗(Denosumab)治疗后骨巨细胞瘤假肉瘤样变伴有高核分裂活性的罕见组织形态特征分析被引量：1
《中国癌症防治杂志》2023年第4期406-410,共5页沈艳 杨通 陈贵东 古婉仪 
目的 探讨地舒单抗(Denosumab)治疗后伴有假肉瘤样改变和高核分裂活性的骨巨细胞瘤的组织形态特征、诊断及鉴别诊断。方法 回顾性分析广州医科大学附属第二医院收治的1例术前经Denosumab治疗3周的骨巨细胞瘤患者的临床、影像学和病理学...
关键词：骨巨细胞瘤 地舒单抗(Denosumab) 组织学特征 鉴别诊断 
A phase III randomized,double-blind,placebo-controlled trial of the denosumab biosimilar QL1206 in postmenopausal Chinese women with osteoporosis and high fracture risk被引量：5
《Acta Pharmacologica Sinica》2023年第2期446-453,共8页Hao Zhang Jie-mei Gu Ai-jun Chao Qun Cheng Dong-hui Teng Jin-ming Yu Bing-wu Wang Ya-nan Huo Li Mao Qiu Zhang Hong Yang Shi-gui Yan Ke-qin Zhang Xue-ling Zhao Hua Lin Yu Pei Zhong Yuan Ru-chun Dai Liang He Li Chen Yong-feng Su Zhong-liang Deng Li You Bo Ban Mei Zhu You-liang Cao Yi-kun Zhu Zhi-jun Li Zhi Zhang Cheng-qing Yi Yi-bing Lu Guang Wang Cui-cui Han Zhen-jiang Wang Xian-xing Li Zhen-lin Zhang 
The current study evaluated the efficacy and safety of a denosumab biosimilar,QL1206(60 mg),compared to placebo in postmenopausal Chinese women with osteoporosis and high fracture risk.At 31 study centers in China,a t...
关键词：denosumab biosimilar postmenopausal osteoporosis Chinese women bone mineral density bone turnover markers adverse events 
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