Objective To investigate the effect of calcitriol on repairing high glucose-induced vascular endothelial cell injury through the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway.
supported by the National Natural Science Foundation of China (32172743);the eammarked fund for China Agriculture Research Systems (CARS-40);the Agricultural Science and Tec hnology Innovation Program (ASTIP)of CAAS.
This study was aimed to investigate the effects of dietary calcitriol or quercetin supplementation on eggshell and bone quality of laying hens.In trial 1,72 Hy-Line Brown layers(80-week-old)with weak-shelled strength(...
Vitamin D,a fat-soluble hormone precursor primarily derived from sunlight exposure,exerts pleiotropic effects within the body,including anticancer activity.Research has demonstrated an association between vitamin D an...
BACKGROUND Calcitriol-induced hypercalcemia has been rarely reported in cases of lung cancer;however,it is frequently reported in cases of lymphoid malignancy and granulomatous disease.We present a rare case of hyperc...
Research was funded by grants from National University of Río Cuarto(UNRC)through the Secretary of Science and Technology(SECYT,PPI 2020-2022,Res 083).
Background:Capacitation is a set of physiological changes sperms undergo to acquire fertilizing capacity.In vivo,this process is directly associated with high calcium levels in sperm cytoplasm.Calcitriol,the vitamin D...
the National Key Research and Development Program of China,No.2017YFC0908104;National Science and Technology Projects,No.2017ZX10203201,No.2017ZX10201201,and No.2017ZX10202202.
BACKGROUND Hepatic fibrosis is a serious condition,and the development of hepatic fibrosis can lead to a series of complications.However,the pathogenesis of hepatic fibrosis remains unclear,and effective therapy optio...
supported by grants from the National Natural Science Foundation of China(No.81441016)and Key R&D Plan in Shaanxi Province of China(No.2020SF-262 and No.2019SF-200).
Objective Cardiac fibroblasts(CFs)proliferation and extracellular matrix deposition are important features of cardiac fibrosis.Various studies have indicated that vitamin D displays an anti-fibrotic property in chroni...
National Natural Science Foundation of China,Grant/Award Numbers:31630047,81874201,81725014;Natural Science Foundation of Shanghai,Grant/AwardNumber:20ZR1452300;Shanghai Municipal Health Bureau,Grant/Award Number:201840359;The National Key Research and Development Program of China,Grant/Award Numbers:2020YFA0509000,2017YFA0503600。
Background:Colorectal cancer(CRC)is one of the most malignant tumorswith high incidence,yet its molecular mechanism is not fully understood,hindering the development of targeted therapy.Metabolic abnormalities are a h...
BACKGROUND Alopecia areata(AA)is an inflammatory disease with autoimmune,environmental,and inherited components directed at the hair follicle,either limited to patchy hair loss over the scalp(Focalis,AF),total loss of...
Background: Tuberculosis is a leading cause of morbidity and mortality in humans worldwide. There is an urgent need for new and effective drugs to treat tuberculosis and shorten the duration of tuberculosis therapy. 1...