PROLIFERATION

作品数：1702被引量：5448H指数：24
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相关领域：医药卫生生物学更多>>
相关作者：苏进梁荩忠刘瑞田浩明张俊平更多>>
相关机构：第二军医大学江苏省人民医院温州医科大学南方医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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HMGN2 accelerates the proliferation and cell cycle progression of glioblastoma by regulating CDC20 expression
《Genes & Diseases》2025年第3期492-507,共16页Jiacheng Zhong Shuang Shi Wen Peng Hongjuan Cui Xiaochuan Sun 
Gliomas represent the most common primary malignant intracranial tumors in adults.Despite recent advances in treatment,the prognosis of patients with glioblastoma remains poor.Epigenetic abnormalities,the hallmarks of...
关键词：CDC20 Epigenetic regulation GLIOMA Histone acetylation HMGN2 
Isoleucyl-tRNA synthetase 2 promotespancreatic ductal adenocarcinomaproliferation and metastasis by stabilizingb-catenin
《Genes & Diseases》2025年第3期478-491,共14页Yixun Jin Xinyang Huang Zhuoxin Wang Berik Kouken Qi Wang Lifu Wang 
supported by the National Natural Science Foundation of China(No.81870385,81702740).
Isoleucyl-tRNA synthetase 2(IARS2),originally regarded as an enzyme ligatingisoleucine to the corresponding tRNA,has been identified as an oncogene recently.However,its function in pancreatic ductal adenocarcinoma(PDA...
关键词：Aminoacyl-tRNA synthetases Isoleucyl-tRNA synthetase 2 Pancreatic ductal adenocarcinoma WNT signaling pathway b-Catenin 
OTUB2 promotes proliferation and metastasis of triple-negative breast cancer by deubiquitinating TRAF6
《Oncology Research》2025年第5期1135-1147,共13页YU QIU RUIHAN LIU SHANSHAN HUANG QIAOTING CAI YI XIE ZHITING HE WEIGE TAN XINHUA XIE 
supported by the National Natural Science Foundation of China(No.82373380,Xinhua Xie).
Objectives:Deubiquitinase OTUB2 plays a critical role in the progression of various tumors.However,its specific role in triple-negative breast cancer(TNBC)remains unclear.This study aims to elucidate the biological fu...
关键词：OTUB2 Tumor necrosis factor receptor-associated factor 6(TRAF6) Triple-Negative Breast Cancer(TNBC) DEUBIQUITINATION 
Reduction of Atp5b protects mice from diet-induced obesity
《Genes & Diseases》2025年第2期18-20,共3页Xiaohua Huang Binting Qin Zhengfeng Fang Lianqiang Che Yan Lin Shengyu Xu Yong Zhuo Lun Hua Xuemei Jiang Mengmeng Sun Hairui Wang De Wu Qingqiang Long Bin Feng 
supported by the National Natural Science Foundation of China (No.32272893);the Program of the Giant Panda Breeding Research Foundation (China) (No.2020CPB-C10).
Obesity related metabolic diseases,including non-alcoholic fatty liver disease,insulin resistance,hyperglycemia,and hyperlipemia,have become major chronic diseases.i,2 As an important enzyme for ATP production,3 ATP5b...
关键词：HOMEOSTASIS metabolism. proliferation. 
RNA-binding motif protein RBM39 enhances the proliferation of gastric cancer cells by facilitating an oncogenic splicing switch in MRPL33
《Acta Pharmacologica Sinica》2025年第4期1068-1081,共14页Cheng-piao Lu Jia-bin Li Dong-bao Li Yu-hong Wang Xiao-gang Jiang Jing-jing Ma Guoqiang Xu 
supported by the National Natural Science Foundation of China(32171437);the National Key R&D Program of China(2019YFA0802401);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB310017);Suzhou Science and Technology Development Project(SZM2023006);Gusu Key Health Talent Program of Suzhou(GSWS2022122);the Young Physician Scientists Program(ML42900323);Interdisciplinary Basic Frontier Innovation Program(YXY2302015)at Suzhou Medical College of Soochow University;the National Center for International Research(2017B01012);the Jiangsu Key Laboratory of Neuropsychiatric Diseases(BM2013003);a project funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
Gastric cancer is a malignant gastrointestinal disease characterized by high morbidity and mortality rates worldwide.The occurrence and progression of gastric cancer are influenced by various factors,including the abn...
关键词：RBM39 MRPL33 gastric cancer PROLIFERATION alternative splicing 
Centromere protein A knockdown inhibits rectal cancer through O6- methylguanine DNA methyltransferase/protein tyrosine phosphatase nonreceptor type 4 axis
《World Journal of Gastrointestinal Oncology》2025年第4期347-364,共18页Ming-Jie Xin Yong Yuan 
This study was reviewed and approved by the Ethic Committee of Medical College of Henan Vocational University of Science and Technology(Approval No.HVUYL414101416920231017001);all participants signed a written informed consent.
BACKGROUND Centromere protein A(CENPA)exhibits an increased expression level in primary human rectal cancer tissues,but its role has not been investigated.AIM To clarify the specific role and mechanism of CENPA in rec...
关键词：Rectal cancer Centromere protein A O6-methylguanine DNA methyltransferase Protein tyrosine phosphatase nonreceptor type 4 PROLIFERATION INVASION 
Retraction:Procaine inhibits the proliferation and migration of colon cancer cells through inactivation of the ERK/MAPK/FAK pathways by regulation of RhoA
《Oncology Research》2025年第4期991-991,共1页Oncology Research Editorial Office 
The published article titled“Procaine inhibits the proliferation and migration of colon cancer cells through inactivation of the ERK/MAPK/FAK pathways by regulation of RhoA”has been retracted from Oncology Research,...
关键词：RHOA PROCAINE colon cancer cells erk mapk fak pathways regulation rhoa migration PROLIFERATION REGULATION 
Retraction:Puerarin inhibits proliferation and induces apoptosis by upregulation of miR-16 in bladder cancer cell line T24
《Oncology Research》2025年第4期993-993,共1页Oncology Research Editorial Office 
The published article titled“Puerarin inhibits proliferation and induces apoptosis by upregulation of miR-16 in bladder cancer cell line T24”has been retracted from Oncology Research,Vol.26,No.8,2018,pp.1227–1234.
关键词：PUERARIN bladder cancer bladder cancer cell line T miR APOPTOSIS PROLIFERATION 
Berberine restrained proliferation,invasion,and migration by targeting the glycogen synthase kinase 3β/β-catenin pathway in lung adenocarcinoma cells
《Oncology and Translational Medicine》2025年第2期58-72,共15页Tenzin Wangmu Chenlu Li Guangsu Han Ping Yi 
Supported by a grant from the National Natural Science Foundation of China(no.82174457)。
Background:Lung cancer is one of the deadliest cancers worldwide,creating a pressing need to develop novel drugs that inhibit oncogenic signaling pathways.Numerous studies have shown that berberine(BBR)has anti–lung ...
关键词：BERBERINE Glycogen synthase kinase 3β Lung adenocarcinoma Non‐small cell lung cancer Β-CATENIN 
PAK2 promotes proliferation,migration,and invasion of lung squamous cell carcinoma through the LIMK1/cofilin signaling pathway
《Journal of Biomedical Research》2025年第2期184-197,I0007-I0012,共20页Congcong Wang Junyan Wang Ruifeng Xu Qiushuang Li Xia Huang Chenxi Zhang Baiyin Yuan 
National Natural Science Foundation of China(Grant No.32300615);Nanjing Medical Science and Technique Development Foundation(Grant No.JQX19010)。
Although p21-activated kinase 2(PAK2)is an essential serine/threonine protein kinase,its role in the progression of lung squamous cell carcinoma(LUSC)has yet to be fully understood.We analyzed PAK2 mRNA levels,DNA cop...
关键词：PAK2 lung squamous cell carcinoma LIMK1 COFILIN 
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