DEUBIQUITINATION

作品数：48被引量：256H指数：10
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相关领域：生物学更多>>
相关作者：陈国栋张祖斌更多>>
相关机构：上海长征医院苏州大学多伦多大学南京大学更多>>
相关期刊：《Chinese Medical Journal》《Signal Transduction and Targeted Therapy》《Genes & Diseases》《Journal of Cancer Metastasis and Treatment》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划天津市自然科学基金国家高技术研究发展计划更多>>
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OTUB2 promotes proliferation and metastasis of triple-negative breast cancer by deubiquitinating TRAF6
《Oncology Research》2025年第5期1135-1147,共13页YU QIU RUIHAN LIU SHANSHAN HUANG QIAOTING CAI YI XIE ZHITING HE WEIGE TAN XINHUA XIE 
supported by the National Natural Science Foundation of China(No.82373380,Xinhua Xie).
Objectives:Deubiquitinase OTUB2 plays a critical role in the progression of various tumors.However,its specific role in triple-negative breast cancer(TNBC)remains unclear.This study aims to elucidate the biological fu...
关键词：OTUB2 Tumor necrosis factor receptor-associated factor 6(TRAF6) Triple-Negative Breast Cancer(TNBC) DEUBIQUITINATION 
Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression
《Genes & Diseases》2025年第2期227-243,共17页Yulan Huangg Yuan Gao Zhenghong Lin Hongming Miao 
supported in part by the National Natural Science Foundation of China (No.82173134);the Chongqing Fund for Outstanding Youth (China) (No.CSTB2022NSCO-JOX0010).
The tumor microenvironment is a complex environment comprising tumor cells,non-tumor cells,and other critical non-cellular components.Some studies about tumor micro-environment have recently achieved remarkable progre...
关键词：Adipose cells DEUBIQUITINATION IMMUNITY Tumor microenvironment Tumor-associated fibroblasts UBIQUITINATION 
LN-439A,a novel BAP1 inhibitor,suppresses the growth of basal-like breast cancer by degrading KLF5
《Acta Pharmacologica Sinica》2025年第3期715-727,共13页Tian-tian Wang Long-long Zhang Fu-bing Li Jie Zhang Zhi-bi Zhang Da-zhao Mi Jian Sun Hong-yan Zhang Chun-yan Wang Yi-hua Chen Ce-shi Chen 
supported by National Key Research and Development Program of China(2020YFA0112300,2023YFA1800403);the National Natural Science Foundation of China(U2102203,82260691,82160461,82472806);the Biomedical Projects of Yunnan Key Science and Technology Program(202302AA310046);the Yunnan Revitalization Talent Support Program(Yunling Shcolar Project to CC),Yunnan(Kunming)Academician Expert Workstation(YSZJGZZ-2020025 to CC);the Key Research and Development Program of Ningxia(2023BEG02010);the Yunnan Fundamental Research Projects(202401AT070171);the Technology Innovation Team of Pathological Diagnosis of Triple Negative Breast Cancer in Kunming Medical University(grant number CXTD202208);Yunnan Revitalization Talent Support Program,Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University(202401AY070001-026).
Basal-like breast cancer(BLBC)is the most malignant subtype of breast cancer because of its aggressive clinical behaviour and lack of effective targeted agents.Krüppel-like factor 5(KLF5)is an oncogenic transcription...
关键词：BLBC LN-439A KLF5 BAP1 DEUBIQUITINATION 
Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages
《Acta Pharmaceutica Sinica B》2025年第2期1039-1055,共17页Xin Liu Yi Fang Mincong Huang Shiliang Tu Boan Zheng Hang Yuan Peng Yu Mengyao Lan Wu Luo Yongqiang Zhou Guorong Chen Zhe Shen Yi Wang Guang Liang 
supported by the National Natural Science Foundation of China(82300589 to Xin Liu,82004042 to Mincong Huang,and 82370244 to Yi Wang);the Zhejiang Provincial Key Scientific Project(2021C03041 to Guang Liang,China).
Inflammatory bowel disease(IBD)is a chronic inflammatory disorder of the gastrointestinal tract,which increases the incidence of colorectal cancer(CRC).In the pathophysiology of IBD,ubiquitination/deubiquitination pla...
关键词：COLITIS Deubiquitinase JOSD2 IMPDH2 INFLAMMATION Inflammatory bowel disease MACROPHAGE Nuclear factor kappa B 
Protein ubiquitination in ovarian cancer immunotherapy:The progress and therapeutic strategy
《Genes & Diseases》2024年第6期273-294,共22页Huiling Guo Jianwei Wei Yuyan Zhang Li Wang Junhu Wan Weiwei Wang Ling Gao Jiajing Li Ting Sun Liwei Ma 
supported by the National Natural Science Foundation of China (No.82002751);the Medical Science and Technology Project of HenanProvince,China (No.SBGJ202102139);China Postdoctoral Science Foundation (No.2020M682361);Excellent Youth Foundation of Henan Province,China (No.222300420071);Outstanding Young Talents of Health Science and Technology Innovation of Henan Province,China (No.YXKC2022033);the Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University,Henan,China (No.QNCXTD2023005).
Ovarian cancer is a common cancer for females,and the incidence and mortality rates are on the rise.Many treatment strategies have been developed for ovarian cancer,including chemotherapy and immunotherapy,but they ar...
关键词：DEUBIQUITINATION Immune-related molecules IMMUNOTHERAPY Ovarian cancer UBIQUITINATION 
Identification of USP2 as a novel target to induce degradation of KRAS in myeloma cells
《Acta Pharmaceutica Sinica B》2024年第12期5235-5248,共14页Yingying Wang Youping Zhang Hao Luo Wei Wei Wanting Liu Weiwei Wang Yunzhao Wu Cheng Peng Yanjie Ji Jianfang Zhang Chujiao Zhu Wenhui Bai Li Xia Hu Lei Hanzhang Xu Leimiao Yin Wei Weng Li Yang Ligen Liu Aiwu Zhou Yueyue Wei Qi Zhu Weiliang Zhu Yongqing Yang Zhijian Xu Yingli Wu 
supported in part by grants from the National Natural Science Foundation of China(82170145,82322067,82100156,and 82374583);CAMS Innovation Fund for Medical Sciences(CIFMS):2019-I2M-5-051;Shanghai Science and Technology Commission(20ZR1430600,20JC1410100);Shanghai Municipal Commission of Health and Family Planning,NO.ZY(2021-2023)-0208;Shandong Provincial Natural Science Foundation(ZR2020QH095);China Postdoctoral Science Foundation funded project(2023M742311).
Inducing the degradation of KRAS represents a novel strategy to combat cancers with KRAS mutation.In this study,we identify ubiquitin-specific protease 2(USP2)as a novel deubiquitinating enzyme of KRAS in multiple mye...
关键词：Ubiquitin-specific protease 2 KRAS Gambogic acid Multiple myeloma DEGRADATION UBIQUITINATION Allosteric pocket DEUBIQUITINATION 
Correction:CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism
《Signal Transduction and Targeted Therapy》2024年第11期5336-5338,共3页Zhen Zhang Jianjun Li Yang Ou Guang Yang Kaiyuan Deng Qiong Wang Zhaoyang Wang Wenhao Wang Quansheng Zhang Hang Wang Wei Sun Peiqing Sun Shuang Yang 
Correction to:Signal Transduction and Targeted Therapy(2020)5:25;https://doi.org/10.1038/s41392-020-0118-x,published online 11 March 2020 The authors noticed one inadvertent mistake in Supplementary Figure S5d that ne...
关键词：ZEB1 METASTASIS FIGURE 
Demethylzeylasteral induces PD-L1 ubiquitin-proteasome degradation and promotes antitumor immunity via targeting USP22
《Acta Pharmaceutica Sinica B》2024年第10期4312-4328,共17页Yanyan Zhang Yun Huang Dianping Yu Mengting Xu Hongmei Hu Qing Zhang Minchen Cai Xiangxin Geng Hongwei Zhang Jianhua Xia Mengmeng Guo Dong Lu Hanchi Xu Linyang Li Xing Zhang Qun Wang Sanhong Liu Weidong Zhang 
funded by the National Key Research and Development Program of China(2022YFC3502000);National Natural Science Foundation of China(Nos.82141203,82374086,and 82104459);Shanghai Municipal Science and Technology Major Project(ZD2021CY001,China);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTDD-202004,China);Science and Technology Commission of Shanghai Municipality(20YF1458700,China);Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(2023YZZ02,China)。
Programmed cell death ligand-1(PD-L1)is a T cell inhibitory immune checkpoint molecule that interacts with programmed cell death-1(PD-1)to promote immune escape of tumor cells.Compared with antibody therapies,small mo...
关键词：DEMETHYLZEYLASTERAL PD-L1 USP22 DEUBIQUITINATION Tumor-infiltrating lymphocytes Colorectal cancer Immune checkpoint blockade Antitumor immunity 
USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells
《Current Medical Science》2024年第4期707-717,共11页Xiao-hui YAN Yin-na ZHU Yan-ting ZHU 
supported by Natural Science Foundation of Shaanxi Province(No.2023-JC-YB-743 and No.2021JQ-905).
Objective Obesity-induced kidney injury contributes to the development of diabetic nephropathy(DN).Here,we identified the functions of ubiquitin-specific peptidase 19(USP19)in HK-2 cells exposed to a combination of hi...
关键词：HK-2 cells high glucose free fatty acid DYSFUNCTION USP19 DEUBIQUITINATION 
Zebrafish usp3 loss promotes hypoxic tolerance by disrupting deubiquitination of K63-polyubiquitinated hif-1αa
《Water Biology and Security》2024年第2期17-30,共14页Jun Li Ziwen Zhou Xiaolian Cai Yanan Song Zhi Li Ziyi Li Wuhan Xiao Jing Wang 
NSFC[31721005 and 31830101 to W.X,31972786 to J.W.];The Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24010308 to W.X.].
The hypoxia-inducible factor(HIF)-mediated hypoxia signaling pathway influences oxygen homeostasis in aerobic organisms.This pathway is regulated by several other pathways.Elucidation of its regulation and the underly...
关键词：Hif-1αa HIF-1Α Hypoxic tolerance usp3 ZEBRAFISH 
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