DEUBIQUITINATION

作品数：45被引量：252H指数：10
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相关作者：陈国栋张祖斌更多>>
相关机构：上海长征医院苏州大学多伦多大学南京大学更多>>
相关期刊：《Genes & Diseases》《Journal of Cancer Metastasis and Treatment》《Plant Communications》《Cellular & Molecular Immunology》更多>>
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Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression
《Genes & Diseases》2025年第2期227-243,共17页Yulan Huangg Yuan Gao Zhenghong Lin Hongming Miao 
supported in part by the National Natural Science Foundation of China (No.82173134);the Chongqing Fund for Outstanding Youth (China) (No.CSTB2022NSCO-JOX0010).
The tumor microenvironment is a complex environment comprising tumor cells,non-tumor cells,and other critical non-cellular components.Some studies about tumor micro-environment have recently achieved remarkable progre...
关键词：Adipose cells DEUBIQUITINATION IMMUNITY Tumor microenvironment Tumor-associated fibroblasts UBIQUITINATION 
Protein ubiquitination in ovarian cancer immunotherapy:The progress and therapeutic strategy
《Genes & Diseases》2024年第6期273-294,共22页Huiling Guo Jianwei Wei Yuyan Zhang Li Wang Junhu Wan Weiwei Wang Ling Gao Jiajing Li Ting Sun Liwei Ma 
supported by the National Natural Science Foundation of China (No.82002751);the Medical Science and Technology Project of HenanProvince,China (No.SBGJ202102139);China Postdoctoral Science Foundation (No.2020M682361);Excellent Youth Foundation of Henan Province,China (No.222300420071);Outstanding Young Talents of Health Science and Technology Innovation of Henan Province,China (No.YXKC2022033);the Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University,Henan,China (No.QNCXTD2023005).
Ovarian cancer is a common cancer for females,and the incidence and mortality rates are on the rise.Many treatment strategies have been developed for ovarian cancer,including chemotherapy and immunotherapy,but they ar...
关键词：DEUBIQUITINATION Immune-related molecules IMMUNOTHERAPY Ovarian cancer UBIQUITINATION 
Identification of USP2 as a novel target to induce degradation of KRAS in myeloma cells
《Acta Pharmaceutica Sinica B》2024年第12期5235-5248,共14页Yingying Wang Youping Zhang Hao Luo Wei Wei Wanting Liu Weiwei Wang Yunzhao Wu Cheng Peng Yanjie Ji Jianfang Zhang Chujiao Zhu Wenhui Bai Li Xia Hu Lei Hanzhang Xu Leimiao Yin Wei Weng Li Yang Ligen Liu Aiwu Zhou Yueyue Wei Qi Zhu Weiliang Zhu Yongqing Yang Zhijian Xu Yingli Wu 
supported in part by grants from the National Natural Science Foundation of China(82170145,82322067,82100156,and 82374583);CAMS Innovation Fund for Medical Sciences(CIFMS):2019-I2M-5-051;Shanghai Science and Technology Commission(20ZR1430600,20JC1410100);Shanghai Municipal Commission of Health and Family Planning,NO.ZY(2021-2023)-0208;Shandong Provincial Natural Science Foundation(ZR2020QH095);China Postdoctoral Science Foundation funded project(2023M742311).
Inducing the degradation of KRAS represents a novel strategy to combat cancers with KRAS mutation.In this study,we identify ubiquitin-specific protease 2(USP2)as a novel deubiquitinating enzyme of KRAS in multiple mye...
关键词：Ubiquitin-specific protease 2 KRAS Gambogic acid Multiple myeloma DEGRADATION UBIQUITINATION Allosteric pocket DEUBIQUITINATION 
Correction:CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism
《Signal Transduction and Targeted Therapy》2024年第11期5336-5338,共3页Zhen Zhang Jianjun Li Yang Ou Guang Yang Kaiyuan Deng Qiong Wang Zhaoyang Wang Wenhao Wang Quansheng Zhang Hang Wang Wei Sun Peiqing Sun Shuang Yang 
Correction to:Signal Transduction and Targeted Therapy(2020)5:25;https://doi.org/10.1038/s41392-020-0118-x,published online 11 March 2020 The authors noticed one inadvertent mistake in Supplementary Figure S5d that ne...
关键词：ZEB1 METASTASIS FIGURE 
Demethylzeylasteral induces PD-L1 ubiquitin-proteasome degradation and promotes antitumor immunity via targeting USP22
《Acta Pharmaceutica Sinica B》2024年第10期4312-4328,共17页Yanyan Zhang Yun Huang Dianping Yu Mengting Xu Hongmei Hu Qing Zhang Minchen Cai Xiangxin Geng Hongwei Zhang Jianhua Xia Mengmeng Guo Dong Lu Hanchi Xu Linyang Li Xing Zhang Qun Wang Sanhong Liu Weidong Zhang 
funded by the National Key Research and Development Program of China(2022YFC3502000);National Natural Science Foundation of China(Nos.82141203,82374086,and 82104459);Shanghai Municipal Science and Technology Major Project(ZD2021CY001,China);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTDD-202004,China);Science and Technology Commission of Shanghai Municipality(20YF1458700,China);Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(2023YZZ02,China)。
Programmed cell death ligand-1(PD-L1)is a T cell inhibitory immune checkpoint molecule that interacts with programmed cell death-1(PD-1)to promote immune escape of tumor cells.Compared with antibody therapies,small mo...
关键词：DEMETHYLZEYLASTERAL PD-L1 USP22 DEUBIQUITINATION Tumor-infiltrating lymphocytes Colorectal cancer Immune checkpoint blockade Antitumor immunity 
USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells
《Current Medical Science》2024年第4期707-717,共11页Xiao-hui YAN Yin-na ZHU Yan-ting ZHU 
supported by Natural Science Foundation of Shaanxi Province(No.2023-JC-YB-743 and No.2021JQ-905).
Objective Obesity-induced kidney injury contributes to the development of diabetic nephropathy(DN).Here,we identified the functions of ubiquitin-specific peptidase 19(USP19)in HK-2 cells exposed to a combination of hi...
关键词：HK-2 cells high glucose free fatty acid DYSFUNCTION USP19 DEUBIQUITINATION 
Zebrafish usp3 loss promotes hypoxic tolerance by disrupting deubiquitination of K63-polyubiquitinated hif-1αa
《Water Biology and Security》2024年第2期17-30,共14页Jun Li Ziwen Zhou Xiaolian Cai Yanan Song Zhi Li Ziyi Li Wuhan Xiao Jing Wang 
NSFC[31721005 and 31830101 to W.X,31972786 to J.W.];The Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24010308 to W.X.].
The hypoxia-inducible factor(HIF)-mediated hypoxia signaling pathway influences oxygen homeostasis in aerobic organisms.This pathway is regulated by several other pathways.Elucidation of its regulation and the underly...
关键词：Hif-1αa HIF-1Α Hypoxic tolerance usp3 ZEBRAFISH 
通过USP7结合分子胶上调P53蛋白被引量：2
《Science Bulletin》2024年第12期1936-1953,共18页李朝阳 王紫英 钟超 张航 刘瑞 安平 马志强 卢俊梅 潘成芳 张兆霖 曹志远 胡健一 邢栋 费一艳 丁澦 鲁伯埙 
supported by the National Natural Science Foundation of China(82050008,92049301,81925012,32200797,32271510,32200602,and 82030106);the Science and Technology Commission of Shanghai Municipality(20JC1410900);Shanghai Municipal Science and Technology Key Laboratory Project(23dz2260100);the Innovation Program of Shanghai Municipal Education Commission(2021-01-07-00-07-E00074);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01);the China Postdoctoral Science Foundation(BX20200093 and 2021M690038)。
Molecular glues are typically small chemical molecules that act at the interface between a target protein and degradation machinery to trigger ternary complex formation.Identifying molecular glues is challenging.There...
关键词：P53 USP7 DEUBIQUITINATION UPREGULATION 
OTUD1 promotes hypertensive kidney fibrosis and injury by deubiquitinating CDK9 in renal epithelial cells
《Acta Pharmacologica Sinica》2024年第4期765-776,共12页Meng-yang Wang Tian-xiang Yu Qin-yan Wang Xue Han Xiang Hu Shi-ju Ye Xiao-hong Long Yi Wang Hong Zhu Wu Luo Guang Liang 
supported by the National Natural Science Foundation of China(82000793 to WL and 82370829 for HZ);the Key Discipline of Zhejiang Province in Public Health and Preventive Medicine(First Class,Category A)at Hangzhou Medical College.
Hypertensive renal disease (HRD) contributes to the progression of kidney dysfunction and ultimately leads to end-stage renal disease. Understanding the mechanisms underlying HRD is critical for the development of the...
关键词：hypertensive renal disease OTUD1 Ang II deubiquitination enzyme CDK9 
Hexyl-pentynoic acid serves as a novel radiosensitizer for breast cancer by inhibiting UCHL3-dependent Rad51 deubiquitination
《Radiation Medicine and Protection》2023年第4期204-213,共10页Zuchao Cai David Lim Beidi Jia Guochao Liu Wenwen Ding Zhendong Wang Zhujun Tian Junxuan Peng Fengmei Zhang Chao Dong Zhihui Feng 
supported by grants from Zhejiang Provincial Natural Science Foundation of China(LQ23H14003);National Natural Science Foundation of China(81472800,82173460);Department of Science and Technology of Shandong Province(2019GSF108083);Zhejiang Provincial Postdoctoral Scientific Research Project Funding(ZJ2022076),China.
Objective:To investigate the effects and underlying mechanism of 2-hexyl-4-pentynoic acid(HPTA),a derivative of valproic acid(VPA),on radiotherapy in breast cancer.Methods:MCF7 cells and 7,12-dimethylbenz-[α]-anthrac...
关键词：2-hexyl-4-pentynoic acid RADIOSENSITIZATION UCHL3 RAD51 Homologous recombination DEUBIQUITINATION 
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