Protein ubiquitination in ovarian cancer immunotherapy:The progress and therapeutic strategy  

作　　者：Huiling Guo Jianwei Wei Yuyan Zhang Li Wang Junhu Wan Weiwei Wang Ling Gao Jiajing Li Ting Sun Liwei Ma 

机构地区：[1]Department of Clinical Laboratory,The First Affliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China [2]Key Clinical Laboratory of Henan Province,Zhengzhou,Henan 450052,China [3]Department of Neurosurgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China [4]Department of Pathology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China [5]Department of Gynecologic Oncology,The Affliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital,Zhengzhou,Henan 450052,China

出　　处：《Genes & Diseases》2024年第6期273-294,共22页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China (No.82002751);the Medical Science and Technology Project of HenanProvince,China (No.SBGJ202102139);China Postdoctoral Science Foundation (No.2020M682361);Excellent Youth Foundation of Henan Province,China (No.222300420071);Outstanding Young Talents of Health Science and Technology Innovation of Henan Province,China (No.YXKC2022033);the Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University,Henan,China (No.QNCXTD2023005).

摘　　要：Ovarian cancer is a common cancer for females,and the incidence and mortality rates are on the rise.Many treatment strategies have been developed for ovarian cancer,including chemotherapy and immunotherapy,but they are often ineffective and prone to drug resistance.Protein ubiquitination is an important class of post-translation modifications that have been found to be associated with various human diseases and cancer development.Recent studies have revealed that protein ubiquitination is involved in the progression of ovarian cancer and plays an important role in the tumor immune process.Moreover,the com-bination of ubiquitinase/deubiquitinase inhibitors and cancer immunotherapy approaches can effectively reduce treatment resistance and improve treatment efficacy,which provides new ideas for cancer treatment.Herein,we review the role of protein ubiquitination in relation to ovarian cancer immunotherapy and recent advances in the use of ubiquitinase/deubiquitinase inhibitorsin combil ationwitncaner mmunotherapy.

关 键 词：DEUBIQUITINATION Immune-related molecules IMMUNOTHERAPY Ovarian cancer UBIQUITINATION 

分 类 号：R737.31[医药卫生—肿瘤]