MACROPHAGE

作品数：818被引量：2784H指数：21
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相关领域：医药卫生更多>>
相关作者：李宁张继刘放李文兰岚更多>>
相关机构：复旦大学中国科学院第二军医大学山东大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization
《Genes & Diseases》2025年第3期508-522,共15页Huijun Qiu Jiang Liu Jingyi You Ou Zhou Chang Hao Yi Shu Deyu Ma Wenjing Zou Linghuan Zhang Enmei Liu Zhengxiu Luo Luo Ren Gang Geng Lin Zou Danyi Peng Zhou Fu 
supported by the General Basic Research Project from the Ministry of Education Key Laboratory of Child Development and Disorders(China)(No.GBRP202115);the Chongqing Science and Technology Bureau Major Project(China)(No.cstc2020jcyj-msxmX0782).
Pulmonary fibrosis is a devastating lung disease without effective treatment options. Sphingosine-1-phosphate receptor 3 (S1pr3), a receptor for the lipid signaling moleculesphingosine-1-phosphate, has been shown to m...
关键词：BLEOMYCIN IL-4 M2 polarization MACROPHAGE Pulmonary fibrosis S1pr3 
Cardiomyocyte proliferation:Advances and insights in macrophage-targeted therapy for myocardial injury
《Genes & Diseases》2025年第3期108-121,共14页Tao Wang Xueyao Wang Weibin Ren Zeyu Sun Yanhui Zhang Nanping Wu Hongyan Diao 
supported by the National Key Research and Development Program of China(No.2021YFA1301100,2021YFA1301101);Shandong Provincial Natural Science Foundation of China(No.SYS202202);the Research Project of Jinan Microecological Biomedicine Shandong Laboratory(China)(No.JNL-2023009Q,JNL-2022012B).
In the mammalian heart,cardiomyocytes undergo a transient window of proliferation that leads to regenerative impairment,limiting cardiomyocyte proliferation and myocardial repair capacity.Cardiac developmental pattern...
关键词：Cardiac regeneration Cardiomyocyte proliferation Heterogeneous macrophages MACROPHAGES Myocardial infarction 
Impaired efferocytosis by monocytes and monocyte-derived macrophages in patients with poorly controlled type 2 diabetes
《World Journal of Diabetes》2025年第5期283-296,共14页Qian-Yun Mao Hui Ran Qiu-Yue Hu Sun-Yue He Yao Lu Han Li Yi-Meng Chai Zhao-Yin Chu Xu Qian Wan Ding Yi-Xin Niu Hong-Mei Zhang Xiao-Yong Li Qing Su 
Supported by National Natural Science Foundation of China,No.81970669,No.82170835,and No.82100848;Shanghai Municipal Health Commission,No.202240107,and No.20234Y0040;China Endocrine Metabolism Research Program of Excellence,No.2023-N-03-05。
BACKGROUND Deficient efferocytosis(i.e.,phagocytic clearance of apoptotic cells)by macrophages has been frequently reported in experimental models of type 2 diabetes(T2D).AIM To translate these findings to humans by t...
关键词：Type 2 diabetes EFFEROCYTOSIS MONOCYTE MACROPHAGE 
Bacterial indole-3-propionic acid inhibits macrophage IL-1βproduction through targeting methionine metabolism
《Science China(Life Sciences)》2025年第4期1118-1131,共14页Ziyi Han Jian Fu Aiyan Gong Wenkai Ren 
supported by the National Natural Science Foundation of China(32225047,U22A20510);Double First-Class Discipline Promotion Project(2023B10564001);National Center of Technology Innovation for Pigs(NCTIP-XD/B13);the Open Project Program of Sichuan Provincial Key Laboratory of Animal Disease-resistant Nutrition,Sichuan Agricultural University(SZ202301-02)。
The gut microbiota plays key roles in host health by shaping the host immune responses through their metabolites,like indole derivatives from tryptophan.However,the direct role of these indole derivatives in macrophag...
关键词：IPA MACROPHAGE MAT2A IL-1Β 
Bacteriocin Microcin J25’s antibacterial infection effects and novel non-microbial regulatory mechanisms: differential regulation of dopaminergic receptors
《Journal of Animal Science and Biotechnology》2025年第2期813-830,共18页Lijun Shang Fengjuan Yang Qingyun Chen Ziqi Dai Guangxin Yang Xiangfang Zeng Shiyan Qiao Haitao Yu 
supported by the National Key Research and Development Program of China(Grant number 32030105);National Pig Technology Innovation Center Leading Technology Projects(NCTIP XD/B05);Beijing Innovation Consortium of Livestock Research System(BAIC05-2024).
Background The antibacterial and immunomodulatory activities of bacteriocins make them attractive targets for development as anti-infective drugs.Although the importance of the enteric nervous system(ENS)in the strugg...
关键词：Arachidonic acid Dopaminergic receptors Enteric nervous system MACROPHAGE MICROBIOTA Microcins 
Lactobacillus alleviates intestinal epithelial barrier function through GPR43-mediated M2 macrophage polarization
《Animal Diseases》2025年第1期56-72,共17页Yong Yao Yuhan Zhang Mengzhen Song Jinping Fan Shengkai Feng Jingjing Li Zhifeng Wu Bo Zuo Shiyu Tao Xiangdong Liu 
supported by the National Nature Science Foundation of China(32272898);the National Key Research and Development Program(2021YFA0805904);the Fundamental Research Funds for the Central Universities(2662020DKQD004).
Lactobacillus species have excellent abilities to reduce intestinal inflammation and enhance gut barrier function.This study elucidated the potential mechanisms through which Lactobacillus mitigates lipopolysaccharide...
关键词：LACTOBACILLUS Butyric acid GPR43 MACROPHAGE Gut barrier 
Role of macrophage in intervertebral disc degeneration
《Bone Research》2025年第1期15-34,共20页Yiming Dou Yiming Zhang Yang Liu Xun Sun Xinyu Liu Bin Li Qiang Yang 
National Natural Science Foundation of China(U24A20670,82372419,82072435);Tianjin Science and Technology Plan Project“Unveiling and Directing”Major Project(21ZXJBSY00130);Beijing-Tianjin-Hebei Basic Research Cooperation Project(J230020)。
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles.Macrophages,as key immune cells,critically regulate inflammation through polarization into diff...
关键词：DEGENERATION INTERVERTEBRAL INFLAMMATION 
Circulating metabolites of Borneolum syntheticum(Bingpian)ameliorate atherosclerosis in ApoE−/−mice via inhibiting macrophage foam-cell formation
《Acta Pharmacologica Sinica》2025年第3期759-776,共18页Rong-rong He Chuan-rui Ma Xin He Yan-xi Dong Hui Li Zi-xuan Chu Xi-he Yang Jia-qi Wang Ting Wang Feng-qing Wang Fei-fei Du Ying Rao Wen-xuan Yu Xiu-mei Gao Guan-wei Fan Chen Cheng Chuan Li 
funded by grants from the National Natural Science Foundation of China(82192912);National Engineering Research Center of TCM Standardization Technology(2023-ZYBZH-10);National Key R&D Program“Strategic Scientific and Technological Innovation Cooperation”Key Project(2022YFE0203600).
Translational pharmacological research on traditional medicines lays the foundation for precisely understanding how the medicines function in the body to deliver therapeutic benefits.Borneolum syntheticum(Bingpian)is ...
关键词：Borneolum syntheticum Bingpian BORNEOL ISOBORNEOL metabolism ATHEROSCLEROSIS 
Lrrk2 promotes M1 macrophage polarization via regulating cytokine(IFN-g)and TLR4(LPS)-mediated responses
《hLife》2025年第2期98-111,I0001-I0005,共19页Yuchen Kang Ping Gao Xiaotong Chen Xiaoyu Zhai Xi Wang Xiaojuan Han Baoqian Jia Baidong Hou Xuyu Zhou Jian Song Fuping Zhang 
supported by a National Key Research and Development Project Grant(2021YFC2300502);the National Natural Science Foundation of China Grants(32370930 and 32360176).
Leucine-rich repeat kinase 2(Lrrk2)has received widespread attention as a risk gene associated with Parkinson’s disease.As the immune response attributes of Parkinson’s disease have been gradually revealed,the link ...
关键词：leucine-rich repeat kinase 2(Lrrk2) M1 macrophage signal transducer and activator of transcription 1(STAT1) 
Shenlian Extract Protects against Ultrafine Particulate Matter-Aggravated Myocardial Ischemic Injury by Inhibiting Inflammation and Cell Apoptosis
《Biomedical and Environmental Sciences》2025年第2期206-218,共13页Shuiqing Qu Yan Liang Shuoqiu Deng Yu Li Yue Dai Chengcheng Liu Tuo Liu Luqi Wang Lina Chen Yujie Li 
supported by CACMS Innovation Fund(No CI2021A04611,CI2021A05106);Scientific and technological innovation project of China Academy of Chinese Medical Sciences(CI2021B015);Scientific and technological innovation project of China Academy of Chinese Medical Sciences(CI2023E001TS01);Fundamental research funds for the central public welfare research institutes(L2022035).
Objective Emerging evidence suggests that exposure to ultrafine particulate matter(UPM,aerodynamic diameter<0.1μm)is associated with adverse cardiovascular events.Previous studies have found that Shenlian(SL)extract ...
关键词：Ultrafine particulate matter Shenlian extract INFLAMMATION Apoptosis MACROPHAGE 
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