INTERVERTEBRAL

作品数：91被引量：176H指数：7
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TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis
《Genes & Diseases》2025年第1期327-340,共14页Cheng Qiu Lin Cheng Derun Di Ziqian Xiang Congyu Wang Jinghang Li Yinuo Xiong Manyu Li Jingwei Liu Jian Zhou Tianyi Liu Xinyu Wang Dan Luo Xiaoxiong Wang Shangye Li Hui Wang Xia Wang Yunpeng Zhao Xinyu Liu Lianlei Wang 
supported in part by the National Natural Science Foundation of China(No.81874022 and 82172483 to Xinyu Liu,No.82102522 to Lianlei Wang);Key R&D Project of Shandong Province(China)(No.2022CXGC010503 to Xinyu Liu);Shandong Natural Science Foundation(No.ZR202102210113 to Lianlei Wang);Shandong Province Taishan Scholar Project(No.tsqn 202211317 to Lianlei Wang);National High Level Hospital Clinical Research Funding(No.2022-PUMCH-D-004).
Intervertebral disc degeneration(IDD)is a common chronic inflammatory degenerative disease that causes lower back pain.However,the underlying mechanisms of IDD remain unclear.Ferroptosis suppressor protein 1(FSP1)is a...
关键词：Caspase 3 FSP1 iFSP1 Intervertebraldisc degeneration NF-ΚB TNFΑ 
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling被引量：1
《Bone Research》2024年第3期555-570,共16页Hanwen Li Yingchuang Tang Zixiang Liu Kangwu Chen Kai Zhang Sihan Hu Chun Pan Huilin Yang Bin Li Hao Chen 
supported by National Natural Science Foundation of China (82172468,82372436 and 32301416);Natural Science Foundation of Jiangsu Province (BK20211326);Natural Science Fund for Colleges and Universities in Jiangsu Province (21KJB320009)。
Degenerated endplate appears with cheese-like morphology and sensory innervation,contributing to low back pain and subsequently inducing intervertebral disc degeneration in the aged population.1 However,the origin and...
关键词：DEGENERATION CARTILAGE INTERVERTEBRAL 
ADAM8 inactivation retards intervertebral disc degeneration in mice
《Genes & Diseases》2024年第3期91-94,共4页Zuozhen Tian Frances S.Shofer Mingyue Fan Alec Z.Sandroni Lutian Yao Lin Han Ling Qin Motomi Enomoto-lwamoto Yejia Zhang 
ADAM8 has been identified as the fibronectin-cleaving enzyme in human degenerative intervertebral disc(IVD)tissues.^(1)Increase of the active form of ADAM8 and its cleavage product,fibronectin fragment,correlated with...
关键词：ADAM8 DEGENERATION INTERVERTEBRAL 
A new perspective on intervertebral disc calcification—from bench to bedside被引量：1
《Bone Research》2024年第1期50-61,共12页Emanuel J.Novais Rajkishen Narayanan Jose A.Canseco Koen van de Wetering Christopher K.Kepler Alan S.Hilibrand Alexander R.Vaccaro Makarand V.Risbud 
support by R01AR055655, R01AR074813, and R01AG073349 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Institute on Aging (NIA);supported by PXE International.
Disc degeneration primarily contributes to chronic low back and neck pain.Consequently,there is an urgent need to understand the spectrum of disc degeneration phenotypes such as fibrosis,ectopic calcification,herniati...
关键词：DEGENERATION metabolism INTERVERTEBRAL 
Progress in regulating inflammatory biomaterials for intervertebral disc regeneration被引量：1
《Bioactive Materials》2024年第3期506-531,共26页Honglin Xiang Weikang Zhao Ke Jiang Jiangtao He Lu Chen Wenguo Cui Yuling Li 
supported by the National Natural Science Foundation of China(82102578,82102571);Special Project for the Central Government to Guide the Development of Local Science and Technology in Sichuan Province(23ZYZYTS0235);China Postdoctoral Science Foundation(2022M720603,2022M710564);Natural Science Foundation of Chongqing(CSTB2022NSCQ-MSX0104,CSTB2022NSCQ-MSX0089);Research Project of Health Commission of Sichuan Province(2023-1601);Research Project of Nanchong Science and Technology Bureau(22SXJCQN0004);Research Project of the Affiliated Hospital of North Sichuan Medical College(2022JB008,2023ZD002).
Intervertebral disc degeneration(IVDD)is rising worldwide and leading to significant health issues and financial strain for patients.Traditional treatments for IVDD can alleviate pain but do not reverse disease progre...
关键词：Intervertebral disc ANTI-INFLAMMATION BIOMATERIALS Tissue regeneration 
Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway被引量：2
《Bioactive Materials》2023年第4期75-90,共16页Zhaojie Wang Huiyi Yang Xu Xu Hongxing Hu Yuxin Bai Jian Hai Liming Cheng Rongrong Zhu 
This work was financially supported by the INTERNATIONAL COOPERATION Project of National Natural Science Foundation of China(Grant No.81810001048);the National Natural Science Foundation of China(Grant Nos.81922039,81873994,31727801,82225027 and 82001308);Key Basic Research Projects of Shanghai Science and Technology Commission(Grant No.19JC141470)。
Chronic low back pain and dyskinesia caused by intervertebral disc degeneration(IDD)are seriously aggravated and become more prevalent with age.Current clinical treatments do not restore the biological structure and i...
关键词：Mesenchymal stem cells Layered double hydroxide Chondrogenic differentiation Intervertebral disc degeneration Focal adhesion signaling pathway 
Retrospective study of acupuncture treatment for canine thoracolumbar intervertebral disc herniation
《One Health Advances》2023年第1期117-126,共10页Qianyu Jia Yu Wang Haidong Pang Kai Fan Huisheng Xie Jiahao Lin 
supported by the 14th Five-Year Plan National Key Research and Development Program of China(2022YFD1801104);the 2115 Talent Development Program of China Agricultural University(Grant no.00109023).
Thoracolumbar interverbal disk herniation(TL-IVDH)is a common neurological disorder in dogs,which often affects the life quality of patients and their caregivers.Acupuncture is increasingly accepted by veterinarians a...
关键词：DOG Thoracolumbar intervertebral disk herniation ACUPUNCTURE REVIEW 
Mechanical properties and microstructure characteristics of lattice-surfaced PEEK cage fabricated by high-temperature laser powder bed fusion被引量：1
《Journal of Materials Science & Technology》2022年第30期105-117,共13页Peng Chen Jin Su Haoze Wang Lei Yang Haosong Cai Maoyuan Li Zhaoqing Li Jie Liu Shifeng Wen Yan Zhou Chunze Yan Yusheng Shi 
financially supported by the National Natural Science Foundation of China(No.52105341);the China Postdoctoral Science Foundation(No.2020M682406);Post-Doctoral Innovative Research Post of Hubei Province(No.257963);the Fundamental Research Funds for the Central Universities(Nos.2019kfyRCPY044and 2021GCRC002);the Program for HUST Academic Frontier Youth Team(No.2018QYTD04);the Guangdong Provincial Enterprise Key Laboratory for 3D Printing Polymer and Composite Materials(No.2018B030323001);the Wenzhou Industrial Science and Technology Project(No.ZG2020048)。
Porous structure design on the contact surface is crucial to promote the osseointegration of the intervertebral cage while preventing subsidence and displacement.However,the stress response will undergo significant ch...
关键词：Additive manufacturing Laser powder bed fusion POLYETHERETHERKETONE Intervertebral cage Mechanical properties 
Pediatric idiopathic intervertebral disc calcification of the cervical spine被引量：1
《Chinese Medical Journal》2022年第13期1625-1627,共3页Jia Liu Jinhao Miao Dongyang Niu Chao Guo Xiaogang Bao Guohua Xu 
To the Editor:Pediatric idiopathic intervertebral disc calcification(PIIVDC)is a rare childhood disease characterized by calcification of the intervertebral disc and can progress to inflammation or extrusion.[1]The ca...
关键词：INTERVERTEBRAL inflammation CERVICAL 
Stem cells in intervertebral disc regeneration-more talk than action?
《BIOCELL》2022年第4期893-898,共6页PETRA KRAUS ANKITA SAMANTA SINA LUFKIN THOMAS LUFKIN 
supported by the Bayard and Virginia Clarkson Endowment Fund and NIH HD099588 both granted to Thomas Lufkin.
Pain and lifestyle changes are common consequences of intervertebral disc degeneration(IVDD)and affect a large part of the aging population.The stemness of cells is exploited in the field of regenerative medicine as k...
关键词：Stem cells MSC Intervertebral disc(IVD) EXOSOME Extracellular matrix(ECM) 
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