ADAM8 inactivation retards intervertebral disc degeneration in mice  

作　　者：Zuozhen Tian Frances S.Shofer Mingyue Fan Alec Z.Sandroni Lutian Yao Lin Han Ling Qin Motomi Enomoto-lwamoto Yejia Zhang 

机构地区：[1]Department of Physical Medicine&Rehabilitation,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA19146,USA [2]Department of Emergency Medicine,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA [3]Department of Orthopedic Surgery,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA [4]School of Biomedical Engineering,Science&Health Systems,Drexel University,Philadelphia,PA 19104,USA [5]Department of Orthopedics/Sports Medicine and Joint Surgery,the First Hospital of China Medical University,Shenyang,Liaoning 110001,China [6]Department of Orthopedics,University of Maryland School ofMedicine,Baltimore,MD21201,USA [7]Section of Rehabilitation Medicine,Corporal Michael J.Crescenz Veterans Affairs Medical Center,Philadelphia,PA 19104,USA

出　　处：《Genes & Diseases》2024年第3期91-94,共4页基因与疾病（英文）

摘　　要：ADAM8 has been identified as the fibronectin-cleaving enzyme in human degenerative intervertebral disc(IVD)tissues.^(1)Increase of the active form of ADAM8 and its cleavage product,fibronectin fragment,correlated with an increased degree of IVD degeneration.1 Furthermore,fibronectin fragments have been shown to accelerate the progression of IVD degeneration.^(2)These findings suggest that ADAM8 may play a role in degenerative disc disease,a clinical problem with tremendous socioeconomic burdens in the United States.

关 键 词：ADAM8 DEGENERATION INTERVERTEBRAL 

分 类 号：Q51[生物学—生物化学]