Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling  

作　　者：Hanwen Li Yingchuang Tang Zixiang Liu Kangwu Chen Kai Zhang Sihan Hu Chun Pan Huilin Yang Bin Li Hao Chen 

机构地区：[1]Department of Orthopedic Surgery,First Affiliated Hospital of Soochow University,Suzhou,P.R.China [2]Orthopedic Institute,Suzhou Medical College,Soochow University,Suzhou,P.R.China [3]Institute of Translational Medicine,Medical College,Yangzhou University,Yangzhou,P.R.China [4]Department of Orthopedic Surgery,Affiliated Hospital of Yangzhou University,Yangzhou,P.R.China

出　　处：《Bone Research》2024年第3期555-570,共16页骨研究（英文版）

基　　金：supported by National Natural Science Foundation of China (82172468,82372436 and 32301416);Natural Science Foundation of Jiangsu Province (BK20211326);Natural Science Fund for Colleges and Universities in Jiangsu Province (21KJB320009)。

摘　　要：Degenerated endplate appears with cheese-like morphology and sensory innervation,contributing to low back pain and subsequently inducing intervertebral disc degeneration in the aged population.1 However,the origin and development mechanism of the cheese-like morphology remain unclear.Here in this study,we report lumbar instability induced cartilage endplate remodeling is responsible for this pathological change.

关 键 词：DEGENERATION CARTILAGE INTERVERTEBRAL 

分 类 号：R681.53[医药卫生—骨科学]