Role of macrophage in intervertebral disc degeneration  

作　　者：Yiming Dou Yiming Zhang Yang Liu Xun Sun Xinyu Liu Bin Li Qiang Yang 

机构地区：[1]Department of Spine Surgery,Tianjin Hospital,Tianjin University,Tianjin,300211,China [2]Clinical School of Orthopedics,Tianjin Medical University,Tianjin,300070,China [3]Department of Orthopaedics,Qilu Hospital of Shandong University,Jinan,250012,China [4]Orthopedic Institute,Department of Orthopedic Surgery,The First Affiliated Hospital,School of Biology&Basic Medical Sciences,Suzhou Medical College,Soochow University,Suzhou,Jiangsu,215007,China

出　　处：《Bone Research》2025年第1期15-34,共20页骨研究(英文版)

基　　金：National Natural Science Foundation of China(U24A20670,82372419,82072435);Tianjin Science and Technology Plan Project“Unveiling and Directing”Major Project(21ZXJBSY00130);Beijing-Tianjin-Hebei Basic Research Cooperation Project(J230020)。

摘　　要：Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles.Macrophages,as key immune cells,critically regulate inflammation through polarization into different phenotypes.In recent years,the role of macrophages in inflammation-related degenerative diseases,such as intervertebral disc degeneration,has been increasingly recognized.Macrophages construct the inflammatory microenvironment of the intervertebral disc and are involved in regulating intervertebral disc cell activities,extracellular matrix metabolism,intervertebral disc vascularization,and innervation,profoundly influencing the progression of disc degeneration.To gain a deeper understanding of the inflammatory microenvironment of intervertebral disc degeneration,this review will summarize the role of macrophages in the pathological process of intervertebral disc degeneration,analyze the regulatory mechanisms involving macrophages,and review therapeutic strategies targeting macrophage modulation for the treatment of intervertebral disc degeneration.These insights will be valuable for the treatment and research directions of intervertebral disc degeneration.

关 键 词：DEGENERATION INTERVERTEBRAL INFLAMMATION 

分 类 号：R73[医药卫生—肿瘤]