TNFΑ

作品数：1129被引量：5005H指数：26
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相关领域：医药卫生更多>>
相关作者：王占科许霖水宋林生朱长庚陈盛强更多>>
相关机构：华中科技大学第二军医大学中国医科大学第三军医大学更多>>
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络赛维对肝细胞脂肪变性的影响及机制
《中国药理学通报》2025年第3期466-474,共9页王燊 蔡金慧 郑琳 张研 曾凯晴 徐启恩 冯燕敏 叶晓霞 
广东省基础与应用基础研究基金项目(No 2018030310106);广东省大学生攀登计划项目(No pdjh2023b0236);广东省大学生创新创业训练计划项目(No S202310571061,S202410571044)。
目的探讨络赛维对肝细胞脂肪变性的影响及作用机制。方法采用游离脂肪酸(free fatty acid,FFA)作用AML^(-1)2和HepG2细胞诱导肝细胞脂肪变性,油红O染色和CCK-8实验确定FFA最佳诱导浓度。络赛维给药后CCK-8实验检测细胞活性,油红O染色观...
关键词：非酒精性脂肪性肝病 玫瑰红景天 络赛维 脂肪变性 TNFΑ PPARG 
TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis
《Genes & Diseases》2025年第1期327-340,共14页Cheng Qiu Lin Cheng Derun Di Ziqian Xiang Congyu Wang Jinghang Li Yinuo Xiong Manyu Li Jingwei Liu Jian Zhou Tianyi Liu Xinyu Wang Dan Luo Xiaoxiong Wang Shangye Li Hui Wang Xia Wang Yunpeng Zhao Xinyu Liu Lianlei Wang 
supported in part by the National Natural Science Foundation of China(No.81874022 and 82172483 to Xinyu Liu,No.82102522 to Lianlei Wang);Key R&D Project of Shandong Province(China)(No.2022CXGC010503 to Xinyu Liu);Shandong Natural Science Foundation(No.ZR202102210113 to Lianlei Wang);Shandong Province Taishan Scholar Project(No.tsqn 202211317 to Lianlei Wang);National High Level Hospital Clinical Research Funding(No.2022-PUMCH-D-004).
Intervertebral disc degeneration(IDD)is a common chronic inflammatory degenerative disease that causes lower back pain.However,the underlying mechanisms of IDD remain unclear.Ferroptosis suppressor protein 1(FSP1)is a...
关键词：Caspase 3 FSP1 iFSP1 Intervertebraldisc degeneration NF-ΚB TNFΑ 
SPAG6通过NF-κB/TNF-α途径促进B-ALL细胞增殖和耐药
《陆军军医大学学报》2024年第24期2723-2735,共13页潘施睿 罗洁 罗菁 尹家秀 赵海秋 苏榕 刘林 
国家自然科学基金面上项目(82070130)。
目的探究精子相关抗原6(sperm-associated antigen 6,SPAG6)对急性B淋巴细胞白血病(B-cell acute lymphoblastic leukemia,B-ALL)细胞增殖及耐药的相关作用机制。方法纳入2019年1月至2023年12月重庆医科大学附属第一医院血液内科收治的5...
关键词：急性B淋巴细胞白血病 精子相关抗原6 细胞增殖 耐药 NF-κB/TNFα 
Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα-TRAF3-TAK1-MAPK axis
《Signal Transduction and Targeted Therapy》2024年第11期5217-5236,共20页Lin Xie Fei Xue Cheng Cheng Wenhai Sui Jie Zhang Linlin Meng Yue Lu Wenjing Xiong Peili Bu Feng Xu Xiao Yu Bo Xi Lin Zhong Jianmin Yang Cheng Zhang Yun Zhang 
supported by grants of the National Natural Science Foundation of China(Nos.82000411,82030051,82241203,81920108003 and 81970366);State Key R&D Program of China(2021YFF0501403);Key R&D Program of Shandong Province(2021SFGC0503,2021ZLGX02,2021ZDSYS05,2020ZLYS05);Shandong Provincial Natural Science Foundation(ZR2020QH023);the Taishan Scholars Program of Shandong Province(C.Z.);China Postdoctoral Science Foundation(2023M742124);Postdoctoral Innovation Talents Support Program(BX20230210).
The pathogenesis of doxorubicin-induced cardiomyopathy remains unclear.This study was carried out to test our hypothesis that ADAM17 aggravates cardiomyocyte apoptosis induced by doxorubicin and inhibition of ADAM17 m...
关键词：DOXORUBICIN CARDIOMYOPATHY markedly 
Tumor necrosis factor α deficiency promotes myogenesis and muscle regeneration
《Zoological Research》2024年第4期951-960,共10页Yu Fu Jing-Ru Nie Peng Shang Bo Zhang Da-Wei Yan Xin Hao Hao Zhang 
Xizang Major Science and Technology Project(XZ202101ZD0005N);Yunnan Major Science and Technology Project(202302AE090015);National Key R&D Program of China(2023ZD04044-04);National Natural Science Foundation of China(32060736)。
Tumor necrosis factorα(TNFα)exhibits diverse biological functions;however,its regulatory roles in myogenesis are not fully understood.In the present study,we explored the function of TNFαin myoblast proliferation,d...
关键词：TNFΑ Muscle-conditional knockout MYOGENESIS REGENERATION Muscle development 
Indoxyl sulphate-TNFαaxis mediates uremic encephalopathy in rodent acute kidney injury
《Acta Pharmacologica Sinica》2024年第7期1406-1424,共19页Ling Jiang Xue-ying Sun Si-qian Wang Yan-lin Liu Ling-jue Lu Wen-han Wu Hao Zhi Zhong-yan Wang Xiao-dong Liu Li Liu 
supported by the National Natural Science Foundation of China (No.82373943,82173844,82204511,and 82073922);the Jiangsu Funding Program for Excellent Postdoctoral Talent (No.1412200067).
Acute kidney injury(AKI)is often accompanied by uremic encephalopathy resulting from accumulation of uremic toxins in brain possibly due to impaired blood-brain barrier(BBB)function.Anionic uremic toxins are substrate...
关键词：RAW264.7 IMPAIRED UREMIC 
The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis被引量：1
《Cellular & Molecular Immunology》2023年第10期1140-1155,共16页Abrar Ul Haq Khan Alaa Kassim Ali Bryan Marr Donghyeon Jo Simin Ahmadvand Claire Fong-McMaster Saeedah Musaed Almutairi Lisheng Wang Subash Sad Mary-Ellen Harper Seung-Hwan Lee 
Natural killer(NK)cells are predominant innate lymphocytes that initiate the early immune response during infection.NK cells undergo a metabolic switch to fuel augmented proliferation and activation following infectio...
关键词：Natural killer cells TNFA TNFR2 GLYCOLYSIS PROLIFERATION Murine cytomegalovirus 
丁酸对TNFα所致肠上皮屏障损伤的保护作用被引量：3
《昆明医科大学学报》2023年第10期10-17,共8页刘路琼 陈通 张永进 谢振荣 何成禄 黄永坤 
国家自然科学基金资助项目(81360068);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202101AY070001-127)。
目的探讨丁酸对TNFα所致肠上皮屏障损伤的保护作用。方法用CCK-8细胞活力检测探索TNFα对Caco2发挥损伤作用的最佳浓度和时间,并以此为基础探索在TNFα发挥损伤作用最佳作用时间附近丁酸对Caco2细胞的保护情况,随后探索TNFα和丁酸共...
关键词：Caco2细胞 溃疡性结肠炎 TNFΑ 丁酸 ZO-1 OCCLUDIN 
作者更正
《养猪》2023年第3期17-17,共1页
我是《养猪》 2018年第3期73-76页《高脂诱导的肥胖型五指山猪TNFα、 IL-1β和IL-6的变化》一文的第一作者孙瑞萍,由于我的工作疏忽,导致文中TNFα和IL-1β引物序列及结果、资助项目编号错误。现通过《养猪》杂志向读者表示深深的歉意...
关键词：TNFΑ 五指山猪 国家自然科学基金项目 引物序列 肥胖型 CAA 
Acute heart failure as an adverse event of tumor necrosis factor inhibitor therapy in inflammatory bowel disease:A review of the literature
《World Journal of Cardiology》2023年第5期217-228,共12页Thais Gagno Grillo Caroline Ferreira da Silva Mazeto Pupo Silveira Ana Elisa Valencise Quaglio Renata de Medeiros Dutra Julio Pinheiro Baima Silmeia Garcia Zanati Bazan Ligia Yukie Sassaki 
Tumor necrosis factor inhibitors(anti-TNFs)are widely used therapies for the treatment of inflammatory bowel diseases(IBD);however,their administration is not risk-free.Heart failure(HF),although rare,is a potential a...
关键词：Tumor necrosis factor inhibitors Inflammatory bowel disease Heart failure Adverse event TNFαreceptor 
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