CARDIOMYOPATHY

作品数：423被引量：972H指数：16
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相关机构：浙江大学医学院附属第二医院山西医科大学浙江大学医学院附属邵逸夫医院江苏省人民医院更多>>
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Tnni3k regulates cardiomyopathy and cardiac conduction disease through Nfatc1 signaling
《Genes & Diseases》2025年第3期50-53,共4页Shi Ouyang Yujuan Niu Le Liu Qiaorong Yi Wuming Qin Hui Cao Tao Liao Rong Xiang Yonghe Ding Yun Deng 
supported in part by the National Natural Science Foundation of China(No.31970504,31772548,82371863,82070394);the NHC Key Laboratory of Birth Defect for Research and Prevention(Hunan Provincial Maternal and Child Health Care Hospital)(No.KF2021003);the Postgraduate Scientific Innovation Fund of Hunan Province,China(No.CX2018B302).
TNNI3K(troponin-I interacting kinase)encodes a duo tyrosine and serine/threonine kinase implicated in cardiomyopathy,arrhythmias,and cardiac conduction disease(CCD).1 However,no direct downstream phosphorylation targe...
关键词：generate splicing mutation splicing mutation zebrafish tnni k ortholog gene tnni k direct downstream phosphorylation targets cardiac conduction disease ccd CARDIOMYOPATHY nfatc signaling 
Mutational single nucleotide polymorphism rs198389 and demethylation promoted natriuretic peptide B gene transcription in heart failure caused by dilated cardiomyopathy
《Genes & Diseases》2025年第2期113-116,共4页Yulong Li Mingzhi Shen Ting Yang Shui Yu Jianyuan Yin Leiming Luo Yali Zhao Ping Ping Shihui Fu 
supported by grants from the Excellent Youth Incubation Program of Chinese People's Liberation Army General Hospital (No.2020-YQPY-007);the Natural Science Foundation of Hainan Province,China (No.821QN389,821MS117,823MS161,820MS124,821MS112,822MS198,820MS126,820QN383,822MS193);the Military Medical Science and Technology Youth Incubation Program (China) (No.20QNPY110,19QNPY060);the Key R&D Program of Hainan Province,China (No.ZDYF2023SHFZ145);the Health Care Project of PLA (China) (No.22BJZ30);the Clinical Medical Research Center Project of Hainan Province,China (LCYX202106,LCYX202201,LCYX202303);the National Key R&D Program of China (No.2018YFC2000400);the National S&T Resource Sharing Service Platform Project of China (No.YCZYPT[2018]07);the Specific Research Fund of Innovation Platform for Academicians of Hainan Province,China (No.YSPTZX202216);the Heatstroke Treatment and Research Center of PLA (China) (No.413EGZ1D10);the Major Science and Technology Programme of Hainan Province,China (No.ZDKJ2019012).
B-type natriuretic peptide(BNP)system is critical to cardiovascular physiological and pathological processes,especially in the development and progression of heart failure(HF)caused by dilated cardiomyopathy(DCMHF).1,...
关键词：CARDIOMYOPATHY DILATED CARDIOVASCULAR 
Combinatorial approach to treat iron overload cardiomyopathy in pediatric patients with thalassemia-major: A systematic review and meta-analysis
《World Journal of Cardiology》2025年第2期93-102,共10页Moaz Safwan Mariam Safwan Bourgleh Aseel Alsudays Khawaja Husnain Haider 
BACKGROUND Iron overload cardiomyopathy is a significant cause of morbidity and mortality in transfusion-dependent thalassemia patients.Standard iron chelation therapy is less efficient in alleviating iron accumulatio...
关键词：AMLODIPINE CARDIOMYOPATHY Iron overload Randomized controlled trials THALASSEMIA 
Mutations in GTPBP3 cause aberrant mitochondrial respiration associated with combined oxidative phosphorylation deficiency 23
《Genes & Diseases》2025年第1期76-79,共4页Qianqian Li Yang Yang Ranran Li Chenguang Yu Kaidi Ren Yin Feng Xing Chen Yi Luan Xiangdong Kong 
supported by the National Natural Science Foundation of China(No.82000321,31900502);Henan Educational Committee Program for Science and Technology Development of Universities(China)(No.22A310022,24A320017);Natural Science Foundation of Henan,China(No.212300410275);Henan Medical Science and Technology Joint Building Program(China)(No.LHGJ20190229,LHGJ20190236,and LHGJ20230283);the Medical Science and Technology Research Project of Henan Province(No.SBGJ202103079,SBGJ202302045).
Combined oxidative phosphorylation deficiency 23(COXPD23,MIM#616198)is a rare autosomal-recessive mitochondrial disorder with variable disease severity ranging from death in early infancy to survival into the second d...
关键词：OXIDATIVE clinical CARDIOMYOPATHY 
DNA-PKcs Phosphorylates Cofilin2 to Induce Endothelial Dysfunction and Microcirculatory Disorder in Endotoxemic Cardiomyopathy
《Research》2024年第4期514-532,共19页Yingzhen Du Pingjun Zhu Yukun Li Jiachi Yu Tian Xia Xing Chang Hang Zhu Ruibing Li Qingyong He 
supported by grants from the NSFC(nos.82200091,82370083,81900252,82000537,and 82170241).
The presence of endotoxemia is strongly linked to the development of endothelial dysfunction and disruption of myocardial microvascular reactivity.These factors play a crucial role in the progression of endotoxemic ca...
关键词：SUSTAINED DAMAGE inhibited 
Focus on cardiac troponin complex:From gene expression to cardiomyopathy
《Genes & Diseases》2024年第6期115-134,共20页Rosetta Ragusa Chiara Caselli 
The cardiac troponin complex(cTn)is a regulatory component of sarcomere.cTn consists of three subunits:cardiac troponin C(cTnC),which confers Ca2+sensitivity to muscle;cTnl,which inhibits the interaction of cross-brid...
关键词：Cardiac troponin CARDIOMYOPATHY Genemutation Post-translational modification THERAPY 
Arrhythmogenic left ventricular cardiomyopathy mimicking acute myocardial infarction
《Journal of Geriatric Cardiology》2024年第12期1141-1146,共6页Cen-Cen WU Le-Qun ZHOU Xin-Yu WANG Ling-Yun ZU Wei-Xian XU 
supported by the Key Clinical Projects of Peking University Third Hospital (BYSYZD2023006).
Arrhythmogenic cardiomyopathy(ACM),also known as hereditary cardiomyopathy,is characterized by a gradual loss of cardiomyocytes,which are replaced by fibrous or fibrofatty tissues.The disease was initially designated ...
关键词：CARDIOMYOPATHY VENTRICULAR initially 
The effects of hypothalamic microglial activation on ventricular arrhythmias in stress cardiomyopathy
《Journal of Geriatric Cardiology》2024年第12期1119-1132,共14页Peng-Qi LIN Quan-Wei PEI Bin LI Jie-Mei YANG Li-Na ZOU De-Zhan SU Jun-Pei ZHANG Hong-Peng YIN Mbabazi Nadine Jun-Jie YANG Nevzorova Vera A Khan Musawir Abbas Zhao-Lei JIANG Jing-Jie LI De-Chun YIN 
supported by the National Natural Science Foundation of China(No.82270320);the Postdoctoral Scientific Research Developmental Found(LBHQ21155);the Distinguished Young Foundations of the First Affiliated Hospital of Harbin Medical University(HYD2020JQ002);the Science Foundation of the First Affiliated Hospital of Harbin Medical University(No.2018 L001).
Background Stress cardiomyopathy(SCM)currently has a high incidence in older adults,and the theories regarding its causes include“catecholamine myocardial toxicity”and“sympathetic hyperactivation”.However,the role...
关键词：CARDIOMYOPATHY VENTRICULAR ACTIVATION 
Dual-chamber pacing confers better myocardial performance and improves clinical outcomes compared to single-chamber pacing
《World Journal of Cardiology》2024年第11期626-631,共6页Bishav Mohan Akash Batta 
The deleterious effects of long term right ventricular pacing are increasingly being recognized today.Current clinical practice favors the implantation of dual-chamber permanent pacemaker which maintains atrioventricu...
关键词：Permanent pacemaker insertion Pacing induced cardiomyopathy Dualchamber pacemaker Left ventricular ejection fraction Atrial fibrillation Heart failure Global longitudinal strain Stroke Cardiovascular outcomes Conduction system pacing 
Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα-TRAF3-TAK1-MAPK axis
《Signal Transduction and Targeted Therapy》2024年第11期5217-5236,共20页Lin Xie Fei Xue Cheng Cheng Wenhai Sui Jie Zhang Linlin Meng Yue Lu Wenjing Xiong Peili Bu Feng Xu Xiao Yu Bo Xi Lin Zhong Jianmin Yang Cheng Zhang Yun Zhang 
supported by grants of the National Natural Science Foundation of China(Nos.82000411,82030051,82241203,81920108003 and 81970366);State Key R&D Program of China(2021YFF0501403);Key R&D Program of Shandong Province(2021SFGC0503,2021ZLGX02,2021ZDSYS05,2020ZLYS05);Shandong Provincial Natural Science Foundation(ZR2020QH023);the Taishan Scholars Program of Shandong Province(C.Z.);China Postdoctoral Science Foundation(2023M742124);Postdoctoral Innovation Talents Support Program(BX20230210).
The pathogenesis of doxorubicin-induced cardiomyopathy remains unclear.This study was carried out to test our hypothesis that ADAM17 aggravates cardiomyocyte apoptosis induced by doxorubicin and inhibition of ADAM17 m...
关键词：DOXORUBICIN CARDIOMYOPATHY markedly 
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