Mutational single nucleotide polymorphism rs198389 and demethylation promoted natriuretic peptide B gene transcription in heart failure caused by dilated cardiomyopathy  

作　　者：Yulong Li Mingzhi Shen Ting Yang Shui Yu Jianyuan Yin Leiming Luo Yali Zhao Ping Ping Shihui Fu 

机构地区：[1]Agency for Offices Admin Pisintrga Ptioinng o sf nC,eSnhtirhaul iM Fiulit af,rhy,Commission,Beijing 100034,China [2]Department of General Practice,Hainan Hospital of Chinese People's Liberation Army General Hospital,Sanya,Hainan 572013,China [3]Central Laboratory,Hainan Hospital of Chinese People's Liberation Army General Hospital,Sanya,Hainan 572013,China [4]Dermatology Department,Hainan Hospital of Chinese People's Liberation Army General Hospital,Sanya,Hainan 572013,China [5]Department of Critical Care,Hainan Hospital of Chinese People's Liberation Army General Hospital,Sanya,Hainan 572013,China [6]Department of Geriatric Cardiology,Chinese People's Liberation Army General Hospital,Beijing 100853,China [7]General Station for Drug and Instrument Supervision and Control,Joint Logistic Support Force of Chinese People's Liberation Army,Beijing 100076,China [8]Department of Cardiology,Hainan Hospital of Chinese People's Liberation Army General Hospital,Hainan Geriatric Disease Clinical Medical Research Center,Hainan Branch of China Geriatric Disease Clinical Research Center,Sanya,Hainan 572013,China

出　　处：《Genes & Diseases》2025年第2期113-116,共4页基因与疾病(英文)

基　　金：supported by grants from the Excellent Youth Incubation Program of Chinese People's Liberation Army General Hospital (No.2020-YQPY-007);the Natural Science Foundation of Hainan Province,China (No.821QN389,821MS117,823MS161,820MS124,821MS112,822MS198,820MS126,820QN383,822MS193);the Military Medical Science and Technology Youth Incubation Program (China) (No.20QNPY110,19QNPY060);the Key R&D Program of Hainan Province,China (No.ZDYF2023SHFZ145);the Health Care Project of PLA (China) (No.22BJZ30);the Clinical Medical Research Center Project of Hainan Province,China (LCYX202106,LCYX202201,LCYX202303);the National Key R&D Program of China (No.2018YFC2000400);the National S&T Resource Sharing Service Platform Project of China (No.YCZYPT[2018]07);the Specific Research Fund of Innovation Platform for Academicians of Hainan Province,China (No.YSPTZX202216);the Heatstroke Treatment and Research Center of PLA (China) (No.413EGZ1D10);the Major Science and Technology Programme of Hainan Province,China (No.ZDKJ2019012).

摘　　要：B-type natriuretic peptide(BNP)system is critical to cardiovascular physiological and pathological processes,especially in the development and progression of heart failure(HF)caused by dilated cardiomyopathy(DCMHF).1,2 Single nucleotide polymorphism(SNP)in the noncoding region,especially the promoter region,might correlate well with plasma BNP levels,and potentially affect the susceptibility of DCM-HF,through interacting with transcription factor and regulating natriuretic peptide B(NPPB)gene transcription.

关 键 词：CARDIOMYOPATHY DILATED CARDIOVASCULAR 

分 类 号：R54[医药卫生—心血管疾病]