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Role of Gold Nanorods Functionalized by Nucleic Acid Nanostructures Carrying Doxorubicin in Synergistic Anti-Cancer Therapy: 《Biomedical and Environmental Sciences》2025年第4期403-415,共13页Hao Wu Huangshui Ma Xinghan Wu Qiang Sun Lin Feng Ruifang Jiang Yanhong Li Quan Shi; supported by the PLAGH Innovation Funds,(Grant No.22QNFC080);the Sichuan Science and Technology Program(Grant No.2023ZYD0064 and 2023YFG0220);the Fundamental Research Funds for the Central Universities(Grant No.YJ202242);the Research Funding from West China School/Hospital of Stomatology, Sichuan University(Grant No.QDJF2022-2);National Undergraduate Training Program for Innovation(Grant No.C2024129736)。; Objective Cancer remains a significant global health challenge, necessitating the development of effective treatment approaches. Developing synergistic therapy can provide a highly promising strategy for anti-cancer t...; 关键词：Gold Nanorods Synergistic therapy NANOMATERIALS Anti-tumor therapy

Shenmai Injection Reduces Cardiomyocyte Apoptosis Induced by Doxorubicin through miR-30a/Bcl-2: 《Chinese Journal of Integrative Medicine》2025年第3期240-250,共11页ZHANG Xiao-nan LI Yan-yang LYU Shi-chao JIA Qiu-jin ZHANG Jun-ping LIU Long-tao; Supported by the National Natural Science Foundation of China(No.81904118);Hospital Capability Enhancement Project of Xiyuan Hospital,China Academy of Chinese Medical Sciences(No.XYZX0201-09);the Special Programme for the Cultivation of Outstanding Young Scientific and Technological Talents of the China Academy of Chinese Medical Sciences(No.ZZ17-YQ-005)。; Objective:To explore the molecular mechanism of Shenmai Injection(SMI)against doxorubicin(DOX)induced cardiomyocyte apoptosis.Methods:A total of 40 specific pathogen-free(SPF)male Sprague Dawley(SD)male rats were divi...; 关键词：Shenmai Injection DOXORUBICIN CARDIOTOXICITY miR-30a/Bcl-2 APOPTOSIS

CircAkap7:A novel circular RNA with a role in Doxorubicin-induced cardiotoxicity: 《Genes & Diseases》2025年第1期110-113,共4页Jiaqin Liu Sa Liu Xiangyun Li Shanshan Wei Taoli Sun Ning Xie Bikui Zhang Wenqun Li; supported by grants from the National Natural Science Foundation of China(No.82173911,81973406,82373970);Hunan Provincial Natural Science Foundation of China(No.2023JJ30761,2023JJ30802);Scientific Research Project of Hunan Provincial Health and Family Planning Commission(China)(No.202113050843);Research Project established by Chinese Pharmaceutical Association Hospital Pharmacy Department(No.CPA-Z05-ZC-2021-002);Changsha Scienceand Technology Project(China)(No.kq2004137);Chinese Anti-Cancer Association HER2 target Chinese Research Fund(No.CORP-239-S5).; Doxorubicin(Dox),an anthracycline chemotherapy drug,is used extensively in cancer chemotherapy and has been studied in depth in relation to cancers including leukemia,small-cell lung cancer,and ovarian cancer.1 Howeve...; 关键词：CHEMOTHERAPY CIRCULAR SPONGE

Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis: 《Acta Pharmacologica Sinica》2025年第1期81-95,共15页Lin wu Li-tao Wang Yu-xin Du Ying-mei Zhang Jun Ren; This work was supported by the National Natural Science Foundation of China(82130011,92249301,and RFIS82250710173).; Doxorubicin(DOx),a common chemotherapeutic agent in cancer therapy,is accompanied by pronounced cardiotoxicity.Ferroptosis has been implicated in the pathogenesis and therapeutics of DOX-induced cardiotoxicity(DIC).As...; 关键词：asiatic acid DOXORUBICIN CARDIOTOXICITY ferroptosis IRON

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment: 《Nano Research》2025年第1期607-617,共11页Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han; supported by the National Key Research and Development Program of China(No.2022YFE0107800);National Natural Science Foundation of China(Nos.82373206,and 82073332);Zhejiang Provincial Natural Science Foundation of China(No.LHDMZ24H300002)。; Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drug...; 关键词：zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) DOXORUBICIN

Tumor targeted and GSH stimuli response a-lactalbumin nanotubes co-delivering doxorubicin and siRNA for cancer therapy: 《Journal of Future Foods》2024年第4期300-308,共9页Guohua Hou Di Wu Xing Li Bin Liu; supported by the China National Postdoctoral Program for Innovative Talents (BX2021364);the China Postdoctoral Science Foundation (2021M703525).; α-Lactalbumin(a-lac),a natural food-sourced protein,exhibits high biocompatibility as delivery systems for small bioactive molecules or RNA.However,their potential clinical application as a delivery system is greatly...; 关键词：α-Lactabumin nanotube Nanocarier Tumor-targeted SIRNA Synergistic effect

Biomimetic cell membrane decorated ZIF-8 nanocarriers with IR-780 and doxorubicin loading for multiple myeloma treatment: 《Aggregate》2024年第6期332-339,共8页Guangtao Gao Junyi Che Peipei Xu Bing Chen Yuanjin Zhao; National Key Research and Development Program of China,Grant/Award Number:2022YFA1105304;National Natural Science Foundation of China,Grant/Award Numbers:32201088,82273954;Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20210010;Fundings for Clinical Trials from the Affiliated Drum Tower Hospital,Medical School of Nanjing University,Grant/Award Number:2022-LCYJ-MS-16。; Several therapeutic drugs including heptamethine cyanine dye(IR-780),doxorubicin(DOX),and others have exhibited positive outcomes in the treatment of multiple myeloma(MM).However,curing MM is still hampered by undesir...; 关键词：BIOMIMETIC bone marrow homing cell membrane drug delivery multiple myeloma PDT/PTT

A combination strategy of DOX and VEGFR-2 targeted inhibitor based on nanomicelle for enhancing lymphoma therapy: 《Chinese Chemical Letters》2024年第12期260-264,共5页Shuheng Zhang Yuanyuan Zhang Wanyu Wang Yuzhu Hu Xinchuan Chen Bilan Wang Xiang Gao; supported by the National Natural Science Foundation of China(Nos.32222046,82172630)。; Lymphoma is a hematological malignancy with an increasing mortality rate.Nevertheless,the treatment strategy against lymphoma remains limited.Doxorubicin(DOX)is a broad-spectrum anti-tumor chemotherapeutic drug,the cl...; 关键词：DOXORUBICIN Apatinib LYMPHOMA Nanomicelle Drug delivery system

Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα-TRAF3-TAK1-MAPK axis: 《Signal Transduction and Targeted Therapy》2024年第11期5217-5236,共20页Lin Xie Fei Xue Cheng Cheng Wenhai Sui Jie Zhang Linlin Meng Yue Lu Wenjing Xiong Peili Bu Feng Xu Xiao Yu Bo Xi Lin Zhong Jianmin Yang Cheng Zhang Yun Zhang; supported by grants of the National Natural Science Foundation of China(Nos.82000411,82030051,82241203,81920108003 and 81970366);State Key R&D Program of China(2021YFF0501403);Key R&D Program of Shandong Province(2021SFGC0503,2021ZLGX02,2021ZDSYS05,2020ZLYS05);Shandong Provincial Natural Science Foundation(ZR2020QH023);the Taishan Scholars Program of Shandong Province(C.Z.);China Postdoctoral Science Foundation(2023M742124);Postdoctoral Innovation Talents Support Program(BX20230210).; The pathogenesis of doxorubicin-induced cardiomyopathy remains unclear.This study was carried out to test our hypothesis that ADAM17 aggravates cardiomyocyte apoptosis induced by doxorubicin and inhibition of ADAM17 m...; 关键词：DOXORUBICIN CARDIOMYOPATHY markedly

Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy: 《Chinese Chemical Letters》2024年第11期406-412,共7页Jiangshan Xu Weifei Zhang Zhengwen Cai Yong Li Long Bai Shaojingya Gao Qiang Sun Yunfeng Lin; supported by the National Key R&D Program of China(No.2019YFA0110600);the National Natural Science Foundation of China(Nos.82370929 and 81970916);the Sichuan Science and Technology Program(Nos.2022NSFSC0002 and 2023YFG022);Sichuan Province Youth Science and Technology Innovation Team(No.2022JDTD0021);Research and Develop Program,West China Hospital of Stomatology Sichuan University(No.RD03202302);the Research Funding from West China School/Hospital of Stomatology Sichuan University(No.QDJF2022-2)。; Triple-negative breast cancer,due to its aggressive nature and lack of targeted treatment,faces serious challenges in breast cancer treatment.Conventional therapies,such as chemotherapy,are encumbered by a range of li...; 关键词：Tetrahedron DNA nanostructure Ferroptosis DOXORUBICIN Breast cancer Combined cancer therapy

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