CircAkap7:A novel circular RNA with a role in Doxorubicin-induced cardiotoxicity  

作　　者：Jiaqin Liu Sa Liu Xiangyun Li Shanshan Wei Taoli Sun Ning Xie Bikui Zhang Wenqun Li 

机构地区：[1]Department of Pharmacy,The Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China [2]Institute of Clinical Pharmacy,Central South University,Changsha,Hunan 410011,China [3]Department of Pharmacy,Jianli People's Hospital,Jingzhou,Hubei 433300,China [4]School of Pharmacy,Hunan University of Chinese Medicine,Changsha,Hunan 410208,China [5]Department of Breast Cancer Medical Oncology,Hunan Cancer Hospital,Changsha,Hunan 410013,China

出　　处：《Genes & Diseases》2025年第1期110-113,共4页基因与疾病(英文)

基　　金：supported by grants from the National Natural Science Foundation of China(No.82173911,81973406,82373970);Hunan Provincial Natural Science Foundation of China(No.2023JJ30761,2023JJ30802);Scientific Research Project of Hunan Provincial Health and Family Planning Commission(China)(No.202113050843);Research Project established by Chinese Pharmaceutical Association Hospital Pharmacy Department(No.CPA-Z05-ZC-2021-002);Changsha Scienceand Technology Project(China)(No.kq2004137);Chinese Anti-Cancer Association HER2 target Chinese Research Fund(No.CORP-239-S5).

摘　　要：Doxorubicin(Dox),an anthracycline chemotherapy drug,is used extensively in cancer chemotherapy and has been studied in depth in relation to cancers including leukemia,small-cell lung cancer,and ovarian cancer.1 However,the dose-dependent cardiotoxicity of Dox seriously limits its clinical application.2 As a type of noncoding RNA with a covalent cyclic structure,circular RNA(circRNA)has emerged as a new and exciting topic.Growing evidence has shown that circRNA is linked to the pathogenesis of various cardiovascular diseases,including Doxorubicin-induced cardiotoxicity(DIC).3 The function of circRNA is closely associated with its cellular sublocalization.CircRNAs distributed in the cytoplasm primarily serve as microRNA(miRNA)sponges that competitively adsorb miRNA and reduce the binding and degradation of the target mRNA by miRNA,leading to indirect up-regulation of the target gene and increased execution of its function.

关 键 词：CHEMOTHERAPY CIRCULAR SPONGE 

分 类 号：R965[医药卫生—药理学]