Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment  

作　　者：Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han 

机构地区：[1]Institute of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China [2]Department of Radiation Oncology,Key Laboratory of Cancer Prevention and Intervention,The Second Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310058,China [3]Hangzhou Institute of Innovative Medicine,Zhejiang University,Hangzhou 310058,China [4]Jinhua Institute of Zhejiang University,Jinhua 321299,China [5]National Key Laboratory of Advanced Drug Delivery and Release Systems,Zhejiang University,Hangzhou 310058,China [6]Polytechnic institute,Zhejiang University,Hangzhou 310015,China

出　　处：《Nano Research》2025年第1期607-617,共11页纳米研究（英文版）

基　　金：supported by the National Key Research and Development Program of China(No.2022YFE0107800);National Natural Science Foundation of China(Nos.82373206,and 82073332);Zhejiang Provincial Natural Science Foundation of China(No.LHDMZ24H300002)。

摘　　要：Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same charge.Based on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic interaction.Then,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting transfection.Moreover,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关 键 词：zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) DOXORUBICIN 

分 类 号：R737.9[医药卫生—肿瘤]