Role of Gold Nanorods Functionalized by Nucleic Acid Nanostructures Carrying Doxorubicin in Synergistic Anti-Cancer Therapy  

作　　者：Hao Wu Huangshui Ma Xinghan Wu Qiang Sun Lin Feng Ruifang Jiang Yanhong Li Quan Shi 

机构地区：[1]Department of Stomatology,the First Medical Centre,Chinese PLA General Hospital,Beijing 100853,China [2]State Key Laboratory of Oral Disease,National Clinical Research Center for Oral Diseases,West China College of Stomatology,Sichuan University,Chengdu 610064,Sichuan,China [3]NHC Key Laboratory of Comparative Medicine,National Human Diseases Animal Model Resource Center,Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases,National Center of Technology Innovation for Animal Model,Institute of Medical Laboratory Animal Science,CAMS&PUMC,Beijing 100021,China

出　　处：《Biomedical and Environmental Sciences》2025年第4期403-415,共13页生物医学与环境科学(英文版)

基　　金：supported by the PLAGH Innovation Funds,(Grant No.22QNFC080);the Sichuan Science and Technology Program(Grant No.2023ZYD0064 and 2023YFG0220);the Fundamental Research Funds for the Central Universities(Grant No.YJ202242);the Research Funding from West China School/Hospital of Stomatology, Sichuan University(Grant No.QDJF2022-2);National Undergraduate Training Program for Innovation(Grant No.C2024129736)。

摘　　要：Objective Cancer remains a significant global health challenge, necessitating the development of effective treatment approaches. Developing synergistic therapy can provide a highly promising strategy for anti-cancer treatment through combining the benefits of various mechanisms.Methods In this study, we developed a synergistic strategy for chemo-photothermal therapy by constructing nanocomposites using gold nanorods(GNRs) and tetrahedral framework nucleic acids(tFNA) loaded with the anti-tumor drug doxorubicin(DOX).Results Our in vitro studies have systematically clarified the anti-cancer behaviors of tFNA-DOX@GNR nanocomposites, characterized by their enhanced cellular uptake and proficient lysosomal escape capabilities. It was found that the key role of tFNA-DOX@GNR nanocomposites in tumor ablation is primarily due to their capacity to induce cytotoxicity in tumor cells via a photothermal effect, which generates instantaneous high temperatures. This mechanism introduces various responses in tumor cells, facilitated by the thermal effect and the integrated chemotherapeutic action of DOX. These reactions include the induction of endoplasmic reticulum stress, characterized by elevated reactive oxygen species levels, the promotion of apoptotic cell death, and the suppression of tumor cell proliferation.Conclusion This work exhibits the potential of synergistic therapy utilizing nanocomposites for cancer treatment and offers a promising avenue for future therapeutic strategies.

关 键 词：Gold Nanorods Synergistic therapy NANOMATERIALS Anti-tumor therapy 

分 类 号：R730.5[医药卫生—肿瘤]