Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy  

作　　者：Jiangshan Xu Weifei Zhang Zhengwen Cai Yong Li Long Bai Shaojingya Gao Qiang Sun Yunfeng Lin 

机构地区：[1]College of Biomedical Engineering,Sichuan University,Chengdu 610065,China [2]State Key Laboratory of Oral Diseases,National Center for Stomatology,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China [3]Department of Orthopedics,Orthopedic Research Institute,West China Hospital,Sichuan University,Chengdu 610041,China [4]Department of Oral Implantology,The Affiliated Stomatological Hospital of Southwest Medical University,Luzhou 646000,China [5]Sichuan Provincial Engineering Research Center of Oral Biomaterials,Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2024年第11期406-412,共7页中国化学快报（英文版）

基　　金：supported by the National Key R&D Program of China(No.2019YFA0110600);the National Natural Science Foundation of China(Nos.82370929 and 81970916);the Sichuan Science and Technology Program(Nos.2022NSFSC0002 and 2023YFG022);Sichuan Province Youth Science and Technology Innovation Team(No.2022JDTD0021);Research and Develop Program,West China Hospital of Stomatology Sichuan University(No.RD03202302);the Research Funding from West China School/Hospital of Stomatology Sichuan University(No.QDJF2022-2)。

摘　　要：Triple-negative breast cancer,due to its aggressive nature and lack of targeted treatment,faces serious challenges in breast cancer treatment.Conventional therapies,such as chemotherapy,are encumbered by a range of limitations,and there is an urgent need for more effective treatment strategies.Ferroptosis,as an iron-dependent form of cell death,has exhibited promising potential in cancer treatment.Combining ferroptosis with other cancer therapies offers new avenues for treatment.Tetrahedral DNA nanostructure(TDN),a novel DNA-based three-dimensional(3D)nanomaterial,is promising drug delivery vehicle and can be utilized for functionalizing inorganic nanomaterials.In this work,we have demonstrated the preparation of Fe_(3)O_(4)-PEI@TDN-DOX nanocomposites and elucidated their antitumor mechanism.The TDN facilitated the enhanced cellular uptake of polyetherimide(PEI)-modified Fe_(3)O_(4),and the delivery of the chemotherapeutic drug doxorubicin(DOX)further augmented their anti-tumor effect.This novel strategy can destroy the tumor redox homeostasis and produce overwhelming lipid peroxides,consequently sensitizing the tumor to ferroptosis.The integration of ferroptosis with other cancer therapies opens up new possibilities for treatment.This research provides valuable mechanistic insights and practical strategies for leveraging nanotechnology to induce ferroptosis and amplify its impact on tumor cells.

关 键 词：Tetrahedron DNA nanostructure Ferroptosis DOXORUBICIN Breast cancer Combined cancer therapy 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]