CARDIOTOXICITY

作品数：129被引量：271H指数：9
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相关领域：医药卫生更多>>
相关作者：李朝霞胡建达杨婷更多>>
相关机构：台北荣民总医院河北医科大学第四医院福建医科大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金高等学校学科创新引智计划天津市自然科学基金更多>>
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Cardiotoxicity in platinum-based chemotherapy:Mechanisms,manifestations,and management
《Cancer Pathogenesis and Therapy》2025年第2期101-108,共8页Bety Rachma Merlyna Savitri Henry Sutanto 
Platinum-based chemotherapy,a cornerstone in the treatment of various malignancies,is often limited by its potential cardiotoxic effects.Understanding these effects is crucial for optimizing patient outcomes and guidi...
关键词：Cardiotoxic agents CHEMOTHERAPY PLATINUM Cancer Cardiovascular disease ONCOLOGY 
Shenmai Injection Reduces Cardiomyocyte Apoptosis Induced by Doxorubicin through miR-30a/Bcl-2
《Chinese Journal of Integrative Medicine》2025年第3期240-250,共11页ZHANG Xiao-nan LI Yan-yang LYU Shi-chao JIA Qiu-jin ZHANG Jun-ping LIU Long-tao 
Supported by the National Natural Science Foundation of China(No.81904118);Hospital Capability Enhancement Project of Xiyuan Hospital,China Academy of Chinese Medical Sciences(No.XYZX0201-09);the Special Programme for the Cultivation of Outstanding Young Scientific and Technological Talents of the China Academy of Chinese Medical Sciences(No.ZZ17-YQ-005)。
Objective:To explore the molecular mechanism of Shenmai Injection(SMI)against doxorubicin(DOX)induced cardiomyocyte apoptosis.Methods:A total of 40 specific pathogen-free(SPF)male Sprague Dawley(SD)male rats were divi...
关键词：Shenmai Injection DOXORUBICIN CARDIOTOXICITY miR-30a/Bcl-2 APOPTOSIS 
CircAkap7:A novel circular RNA with a role in Doxorubicin-induced cardiotoxicity
《Genes & Diseases》2025年第1期110-113,共4页Jiaqin Liu Sa Liu Xiangyun Li Shanshan Wei Taoli Sun Ning Xie Bikui Zhang Wenqun Li 
supported by grants from the National Natural Science Foundation of China(No.82173911,81973406,82373970);Hunan Provincial Natural Science Foundation of China(No.2023JJ30761,2023JJ30802);Scientific Research Project of Hunan Provincial Health and Family Planning Commission(China)(No.202113050843);Research Project established by Chinese Pharmaceutical Association Hospital Pharmacy Department(No.CPA-Z05-ZC-2021-002);Changsha Scienceand Technology Project(China)(No.kq2004137);Chinese Anti-Cancer Association HER2 target Chinese Research Fund(No.CORP-239-S5).
Doxorubicin(Dox),an anthracycline chemotherapy drug,is used extensively in cancer chemotherapy and has been studied in depth in relation to cancers including leukemia,small-cell lung cancer,and ovarian cancer.1 Howeve...
关键词：CHEMOTHERAPY CIRCULAR SPONGE 
Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis
《Acta Pharmacologica Sinica》2025年第1期81-95,共15页Lin wu Li-tao Wang Yu-xin Du Ying-mei Zhang Jun Ren 
This work was supported by the National Natural Science Foundation of China(82130011,92249301,and RFIS82250710173).
Doxorubicin(DOx),a common chemotherapeutic agent in cancer therapy,is accompanied by pronounced cardiotoxicity.Ferroptosis has been implicated in the pathogenesis and therapeutics of DOX-induced cardiotoxicity(DIC).As...
关键词：asiatic acid DOXORUBICIN CARDIOTOXICITY ferroptosis IRON 
Cardiovascular diseases in patients with cancer:A comprehensive review of epidemiological trends,cardiac complications,and prognostic implications
《Chinese Medical Journal》2025年第2期143-154,共12页Ali A.Alshahrani Evangelos Kontopantelis Catharine Morgan Rathi Ravindrarajah Glen P.Martin Mamas A.Mamas 
This article provides an overview of the current evidence on the epidemiology,overlapping risk factors,and pathophysiology of cardiovascular disease(CVD)in patients with cancer.It explores the cardiotoxic effects of a...
关键词：Cardiovascular disease CVD CANCER EPIDEMIOLOGY CARDIOTOXICITY Cancer therapy Risk factors Cancer survivorship 
Progress in the Application of Noninvasive Myocardial Work to Evaluate Chemotherapy-Related Cardiotoxicity
《Journal of Biosciences and Medicines》2024年第12期351-360,共10页Ling Guo Qiang Zhang Jinshu Wang Xinyu Hao 
Due to advances in modern tumor treatments, patients can survive long-term. However, cardiotoxicity caused by tumor therapy poses a significant challenge to both physicians and patients. Early detection and accurate a...
关键词：Noninvasive Myocardial Work CARDIOTOXICITY Anthracycline Chemotherapy Pressure-Strain Loop Left Ventricular Pressure 
Cardiotoxicity concerns in total joint arthroplasty
《World Journal of Orthopedics》2024年第11期1007-1014,共8页Chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng 
This editorial examines the cardiotoxic effects of elevated metal concentrations in patients who received total joint arthroplasty,as detailed in the study of Brennan et al.The study findings reveal that elevated coba...
关键词：CARDIOTOXICITY Joint arthroplasty Metal ions COBALT Cardiac function 
Geraniol alleviates cyclophosphamide-induced cardiotoxicity in mice被引量：1
《Asian Pacific Journal of Tropical Biomedicine》2024年第10期427-435,共9页Shahid Karim Rasheed A.Shaik 
The Deanship of Scientific Research at King Abdulaziz University,Jeddah,Saudi Arabia has funded this project under grant no.RG-21-166-43.
Objective:To explore the effect of geraniol on cyclophosphamide-induced cardiotoxicity.Methods:Mice were divided into five groups:the control group,the cyclophosphamide group(200 mg/kg cyclophosphamide,i.p.on day 7),t...
关键词：GERANIOL CARDIOTOXICITY Natural product CYCLOPHOSPHAMIDE INFLAMMATION APOPTOSIS 
Cynaroside regulates the AMPK/SIRT3/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis被引量：1
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第9期756-772,共17页Hai ZOU Mengyu ZHANG Xue YANG Huafeng SHOU Zhenglin CHEN Quanfeng ZHU Ting LUO Xiaozhou MOU Xiaoyi CHEN 
Zhejiang Traditional Chinese Medicine Science and Technology Project(Nos.2022ZZ004 and GZY-ZJ-KJ-Z24062),China.
Doxorubicin(DOX)is a commonly administered chemotherapy drug for treating hematological malignancies and solid tumors;however,its clinical application is limited by significant cardiotoxicity.Cynaroside(Cyn)is a flavo...
关键词：Cynaroside DOXORUBICIN PYROPTOSIS CARDIOTOXICITY Oxidative stress 
Thrombopoietin ameliorates doxorubicin-induced toxicities in H9c2 myocardiocytes by inhibiting oxidative stress through the SIRT1/p38 MAPK signaling pathway
《Asian Pacific Journal of Tropical Biomedicine》2024年第9期410-416,共7页Xu-Han Zuo Yu Huang Bo-Cen Chen Ming-Yue Zhu Cai-Cai Zhang Han-Yi Jiao Li-Fang Lu Man Xiao Han Wang 
supported by the Natural Science Foundation of Hainan Province High-level Talent Project(grant number 820RC644);Innovative Research Projects for Postgraduate Students at Hainan Medical University(grant number HYYS2022B08).
Objective:To explore whether thrombopoietin can exert a protective effect against doxorubicin-induced cardiotoxicity by modulating the sirtuin 1(SIRT1)signaling pathway.Methods:H9c2 cell viability was determined by CC...
关键词：DOXORUBICIN THROMBOPOIETIN Oxidative stress Sirtuin 1 CARDIOTOXICITY 
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