THROMBOPOIETIN

作品数：32被引量：106H指数：7
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相关领域：医药卫生更多>>
相关作者：罗广平汪传喜杨默李树浓张丽蓉更多>>
相关机构：广州血液中心香港中文大学中山大学广东药学院更多>>
相关期刊：《South China Journal of Cardiology》《Cellular & Molecular Immunology》《Science China(Life Sciences)》《日本医学介绍》更多>>
相关基金：国家重点基础研究发展计划国家自然科学基金广州市医药卫生科技项目广州市科技计划项目更多>>
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Thrombopoietin ameliorates doxorubicin-induced toxicities in H9c2 myocardiocytes by inhibiting oxidative stress through the SIRT1/p38 MAPK signaling pathway
《Asian Pacific Journal of Tropical Biomedicine》2024年第9期410-416,共7页Xu-Han Zuo Yu Huang Bo-Cen Chen Ming-Yue Zhu Cai-Cai Zhang Han-Yi Jiao Li-Fang Lu Man Xiao Han Wang 
supported by the Natural Science Foundation of Hainan Province High-level Talent Project(grant number 820RC644);Innovative Research Projects for Postgraduate Students at Hainan Medical University(grant number HYYS2022B08).
Objective:To explore whether thrombopoietin can exert a protective effect against doxorubicin-induced cardiotoxicity by modulating the sirtuin 1(SIRT1)signaling pathway.Methods:H9c2 cell viability was determined by CC...
关键词：DOXORUBICIN THROMBOPOIETIN Oxidative stress Sirtuin 1 CARDIOTOXICITY 
Recombinant human thrombopoietin in alleviating endothelial cell injury in sepsis被引量：1
《Journal of Intensive Medicine》2024年第3期384-392,共9页Yun Xie Hui Lv Daonan Chen Peijie Huang Shaohong Wu Hongchao Shi Qi Zhao Ruilan Wang 
supported by grants from the Shenkang Municipal Hospital emerging Frontier technology joint project(grant no.SHDC12019131);the National Natural Science Foundation of China(grant no.82202423);the Clinical Research Innovation Plan of Shanghai General Hospital(grant no.CCTR-2022B04);the 3rd Sansheng TCP Young and Middleaged Scientific Research Funding;Shanghai Jiao Tong University“Medicine-Engineering Interdisciplinary Research Fund”(grant no.YG2021QN79);National Key Clinical Specialist Construction Project(grant no.Z155080000004);Shanghai Committee(grant no.23Y31900100).
Background To evaluate the effect of recombinant human thrombopoietin(rhTPO)on clinical prognosis by exploring changes in endothelial cell injury markers and inflammatory factors in patients with sepsis after treatmen...
关键词：THROMBOPOIETIN SEPSIS Endothelial cells 
Effects of thrombopoietin pre-treatment on peri-liver transplantation thrombocytopenia in a mouse model of cirrhosis with hypersplenism被引量：2
《World Journal of Gastrointestinal Surgery》2023年第10期2115-2122,共8页Zi-Rong Liu Ya-Min Zhang Zi-Lin Cui Wen Tong 
All procedures involving animals were reviewed and approved by the Tianjin Tiancheng New Drug Evaluation Co.,Ltd(Approval No.2023041701).
BACKGROUND During cirrhosis,the liver is impaired and unable to synthesize and clear thrombopoietin properly.At the same time,the spleen assumes the function of hemofiltration and storage due to liver dysfunction,resu...
关键词：Thrombopoietin pre-treatment CIRRHOSIS Liver transplantation Perioperative period PLATELET 
Combination of two target agonists of the thrombopoietin and thrombopoietin receptor in the treatment of elderly patients with refractory immune thrombocytopenia
《Cancer Pathogenesis and Therapy》2023年第2期154-156,共3页Jundong Zhang Zining Wang Haoran Chen Xuechun Lu 
supported by the National Key Research and Development Program of China(No.2020YFC2002706);the Army Health Care Special Project(No.19BJZ28).
Immune thrombocytopenia(ITP)is common in the elderly.Because of the coexistence of multiple diseases,there are many reservations regarding corticosteroid use in the elderly.Thrombopoietin(TPO)and its analogs can promo...
关键词：Immune thrombocytopenia(ITP) TPO-MPL signaling Pathway rh-TPO ELTROMBOPAG 
Switching between eltrombopag and recombinant human thrombopoietin in patients with immune thrombocytopenia: an observational study被引量：1
《Chinese Medical Journal》2022年第19期2344-2350,共7页Xuan Cai Xiaixia Fu Xiangyu Zhao Jin Lu Qian Jiang Yingjun Chang Xiaojun Huang Xiaohui Zhang 
Beijing Natural Science Foundation(No.H2018206423);National Natural Science Foundation of China(No.81970113);Key Program of National Natural Science Foundation of China(No.81730004);National Key Research and Development Program of China(No.2017YFA0105503)。
Background:Recombinant human thrombopoietin(rh-TPO)and eltrombopag are two distinct TPO receptor agonists(TPO-RAs)with different mechanisms.During the pandemic,when immunosuppressive medications are controversial,swit...
关键词：Immune thrombocytopenia Treatment switching Treatment outcome ELTROMBOPAG THROMBOPOIETIN 
Thrombocytopenia in chronic liver disease:Physiopathology and new therapeutic strategies before invasive procedures被引量：12
《World Journal of Gastroenterology》2022年第30期4061-4074,共14页Paolo Gallo Francesca Terracciani Giulia Di Pasquale Matteo Esposito Antonio Picardi Umberto Vespasiani-Gentilucci 
Chronic liver disease is characterized by several hematological derangements resulting in a complex and barely rebalanced haemostatic environment.Thrombocytopenia is the most common abnormality observed in these patie...
关键词：THROMBOCYTOPENIA Chronic liver disease Thrombopoietin agonists Platelet transfusions Avatrombopag Lusutrombopag 
Correlation between thrombopoietin and inflammatory factors,platelet indices,and thrombosis in patients with sepsis:A retrospective study被引量：1
《World Journal of Clinical Cases》2022年第13期4072-4083,共12页Wan-Hua Xu Li-Chan Mo Mao-Hua Shi Hui Rao Xiao-Yong Zhan Mo Yang 
Supported by the Guangdong Province Medical Science and Technology Research Foundation,No.B2014377;the Medical Scientific Research Project of Foshan,No.20190036.
BACKGROUND Thrombopoietin(TPO)is a primary regulator of thrombopoiesis in physiological conditions.TPO,in combination with its specific cytokine receptor c-Mpl,drives platelet production by inducing the proliferation ...
关键词：SEPSIS THROMBOPOIETIN INTERLEUKIN-21 PLATELETS THROMBOSIS 
High plasma CD40 ligand level is associated with more advanced stages and worse prognosis in colorectal cancer
《World Journal of Clinical Cases》2022年第13期4084-4096,共13页Zoltan Herold Magdolna Herold Gyorgy Herczeg Agnes Fodor Attila Marcell Szasz Magdolna Dank Aniko Somogyi 
Supported by the National Research,Development and Innovation Office,No.K-116128;the New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research,Development and Innovation Fund,No.UNKP-20-4-I.
BACKGROUND Colorectal cancer(CRC)is often associated with elevated platelet count(>400×10^(9)/L),known as thrombocytosis.The role of CD40 ligand(CD40L),a member of the tumor necrosis factor family,is controversial in...
关键词：CD40 ligand Colorectal neoplasms INTERLEUKIN-6 THROMBOCYTOSIS THROMBOPOIETIN 
Pathogenesis of Thrombocytopenia in Chronic HCV Infection:A Review被引量：9
《Journal of Clinical and Translational Hepatology》2020年第2期184-191,共8页Sarah Rawi George Y Wu 
A large proportion of patients with chronic hepatitis C have associated thrombocytopenia (TCP). Due to bleeding risks, TCP, when severe, can limit diagnostic and therapeutic procedures, treatments, and increases risk ...
关键词：THROMBOCYTOPENIA Chronic hepatitis AUTOANTIBODIES HYPERSPLENISM THROMBOPOIETIN 
Thrombopoietin-receptor agonists in perioperative treatment of patients with chronic liver disease
《World Journal of Meta-Analysis》2020年第3期220-232,共13页Kamran Qureshi Alan Bonder 
Thrombocytopenia is a multifactorial disorder that is common in patients with chronic liver disease(CLD),leading to challenging perioperative planning.As thrombocytopenia in CLD is associated with thrombopoietin(TPO)d...
关键词：Chronic liver disease THROMBOCYTOPENIA THROMBOPOIETIN Receptor agonist Avatrombopag Lusutrombopag Romiplostim PERIOPERATIVE 
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