All procedures involving animals were reviewed and approved by the Tianjin Tiancheng New Drug Evaluation Co.,Ltd(Approval No.2023041701).
BACKGROUND During cirrhosis,the liver is impaired and unable to synthesize and clear thrombopoietin properly.At the same time,the spleen assumes the function of hemofiltration and storage due to liver dysfunction,resu...
Hepatocellular carcinoma(HCC)is the second leading cause of cancer-related deaths globally and is widely considered to be a serious threat to human health.In clinical settings,more than 70%of HCCs are unresectable at ...
Supported by Hainan Provincial Department of Science and Technology,Qiongke[2020]256。
BACKGROUND Hypersplenism associated with cirrhotic portal hypertension is a common condition often resulting from hepatitis B-related cirrhosis.However,the levels of immunoglobulin(Ig)and complement in patients with h...
National Natural Science Foundation of China,No.81870444;Tianjin Natural Science Foundation,No.19JCQNJC10300;Spring Bud Plan of Tianjin First Central Hospital,No.TFCHCL201801.
BACKGROUND The most effective treatment for advanced cirrhosis and portal hypertension is liver transplantation(LT).However,splenomegaly and hypersplenism can persist even after LT in patients with massive splenomegal...
A large proportion of patients with chronic hepatitis C have associated thrombocytopenia (TCP). Due to bleeding risks, TCP, when severe, can limit diagnostic and therapeutic procedures, treatments, and increases risk ...
AIM To determine the outcomes of partial splenic em-bolization(PSE) for massive splenomegaly due to idiopathic portal hypertension(IPH).METHODS In this prospective study, we evaluated the charac-teristics and prognosi...
supported by a grant from the National Natural Science Foundation of China(No.81402410)
This study aimed to examine the efficacy of the laparoscopic vs. traditional open splenectomy for hepatocellular carcinoma(HCC) with hypersplenism. Between 2002 and 2013, 51 Chinese HCC patients with hypersplenism u...
Objective:To discover the effect of partial splenic embolization on the immune function of cirrhotic patients with hypersplenism.Methods:Patients involved in the study were enrolled and divided into three groups,inclu...
Background: Lymphocyte subsets play important roles in rejection in liver transplant recipients, and the effect of splenic function on these roles remains unknown. The aim of this study was to explore the feasibility...
BACKGROUND:Splenectomy in patients with liver cirrhosis(LC)is expected to become more common owing to its efficacy on portal hemodynamics.In this report we describe an alarming case of group B streptococcus(GBS)infect...