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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications
《Neural Regeneration Research》2025年第5期1324-1335,共12页Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh 
supported by the Department of Veterans Affairs(VA Merit Award BX004256)(to AMA);Emory Department of Neurosurgery Catalyst Grant;Emory Medical Care Foundation Grant(to AMA and JG)。
Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery...
关键词：COMPLEMENT NEUROINFLAMMATION NEUROPLASTICITY regeneration spinal cord injury targeted therapy 
Research progress on the roles of complement in liver injury
《World Journal of Hepatology》2025年第3期13-24,共12页Li-Li Ou Jin-Lian Jiang Man-Lu Guo Jin-Hua Wu Wei-Wei Zhong Yi-Huai He 
Supported by the Science and Technology Planning Projects of Guizhou Province,No.QKHJC-ZK[2022]YB642;the Science and Technology Planning Projects of Zunyi City,No.ZSKHHZ(2022)344;the WBE Liver Fibrosis Foundation,No.CFHPC2025028;the Chinese Foundation for Hepatitis Prevention and Control Muxin Research Fund of CHB,No.MX202404;Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund,No.iGandanF-1082024-Rgg018;the Graduate Research Fund Project of Zunyi Medical University,No.ZYK246;the Student Innovation and Entrepreneurship Training Program of Zunyi Medical University,No.2024106610923 and No.S202310661028.
The complement system is crucial for maintaining immunological homeostasis in the liver,playing a significant role in both innate and adaptive immune responses.Dysregulation of this system is closely linked to the pat...
关键词：Complement system Liver injury Immune homeostasis PATHOGENESIS REVIEW 
Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis被引量：1
《Neural Regeneration Research》2025年第3期821-835,共15页Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu 
supported by the Fundamental Research Program of Shanxi Province of China,No.20210302124277;the Science Foundation of Shanxi Bethune Hospital,No.2021YJ13(both to JW)。
Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive impairment.However,the mechanism underlying this neurogenesis impairment remains unknown.In ...
关键词：complement C1 dendrite dentate gyrus hippocampus neural stem cell NEUROGENESIS NEUROINFLAMMATION neurological function neuron traumatic brain injury 
Thyroid hormone,immunoglobin and complements for predicting hepatocellular carcinoma development in patients with hepatitis B virus-related liver cirrhosis
《World Journal of Hepatology》2025年第2期130-139,共10页Xue-Cheng Tong Kai Liu Ze-Yu Huang Xiu-Jun Zhang Yuan Xue 
Supported by The Research Foundation of Jiangsu Province Administration of Traditional Chinese Medicine,No.MS2023088;The Science and Technology Project of Changzhou,No.CE20225040;The Research Foundation of Nanjing Medical University Changzhou Medical Center,No.CMCC202311;Leading Talent of Changzhou“The 14th Five-Year Plan”High-Level Health Talents Training Project,No.2022CZLJ021.
BACKGROUND Hepatocellular carcinoma(HCC)surveillance is crucial for patients with compensated cirrhosis(CC)and decompensated cirrhosis(DC).Increasing evidence has revealed a connection between thyroid hormone(TH)and H...
关键词：Thyroid hormone IMMUNOGLOBULIN COMPLEMENT Hepatocellular carcinoma Prediction 
C3 glomerulopathy post kidney transplantation:A single center experience
《World Journal of Transplantation》2025年第2期245-256,共12页Jonathan Zuckerman Phuong-Thu Pham Meena Parakkal Alexis F Velazquez Mrinalini Sarkar Michael A Pablos Suphamai Bunnapradist Erik L Lum 
BACKGROUND C3 glomerulopathies(C3G)are a rare cause of kidney failure resulting from complement dysregulation.Small studies demonstrate a high rate of recurrence and poor outcomes in kidney transplantation.Treatment e...
关键词：C3 glomerulopathy Dense deposit disease C3 glomerulonephritis Kidney transplant Renal pathology Kidney biopsy Recurrent disease Complement disorder 
Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy
《Military Medical Research》2024年第5期794-796,共3页Stanislovas S.Jankauskas Fahimeh Varzideh Pasquale Mone Urna Kansakar Francesco Di Lorenzo Angela Lombardi Gaetano Santulli 
National Institutes of Health(NIH):National Heart,Lung,and Blood Institute(NHLBI:R01-HL164772,R01-HL159062,R01-HL146691,T32-HL144456);National Institute of Diabetes and Digestive and Kidney Diseases(NIDDK:R01-DK123259,R01-DK033823);National Center for Advancing Translational Sciences(NCATS:UL1-TR002556-06,UM1-TR004400)(to Gaetano Santulli);Diabetes Action Research and Education Foundation(to Gaetano Santulli);Monique Weill-Caulier and Irma T.Hirschl Trusts(to Gaetano Santulli).
Diabetic cardiomyopathy is a disorder of the cardiac muscle that affects patients with diabetes.The exact mechanisms underlying diabetic cardiomyopathy are mostly unknown,but several factors have been implicated in th...
关键词：Adipsin Complement factor D INTERLEUKIN-1 Interleukin-1 receptor-associated kinase like 2(Irak2) Opa1 Prohibitin(PHB) 
Complement activation targeted inhibitor C2-FH ameliorates acetaminophen-induced liver injury in mice被引量：1
《World Journal of Hepatology》2024年第10期1188-1198,共11页Chun-Mei Li Tian Sun Mou-Jie Yang Zhi Yang Qing Li Jia-Lin Shi Chong Zhang Jun-Fei Jin 
Supported by Natural Science Foundation of Guangxi,No.2020GXNSFDA238006;Special Fund of the Central Government Guiding Local Scientific and Technological Development by Guangxi Science and Technology Department,No.GuikeZY21195024;Research Enhancement Project for Junior Faculty in Higher Education Institutes of Guangxi,No.2018KY0419.
BACKGROUND Complement activation is recognized as an important factor in the progression of liver damage caused by acetaminophen(APAP).However,the role of the complement inhibitor C2-FH in APAP-induced liver injury re...
关键词：C2-FH COMPLEMENT Complement activation Acetaminophen-induced liver injury Inflammation 
Clinicopathological significance of extraglomerular complement C1q deposition in lupus nephritis patients
《China Medical Abstracts(Internal Medicine)》2024年第3期182-182,共1页YANG Xiaoqing 
Objective To investigate the extraglomerular deposition of C1q in patients with lupus nephritis (LN)and explore its clinicopathological significance,and to provide immunological evidence for the mechanism of renal tub...
关键词：C1Q NEPHRITIS PATIENTS 
What is new in the pathogenesis and treatment of IgA glomerulonephritis
《World Journal of Nephrology》2024年第4期13-27,共15页Maurizio Salvadori Giuseppina Rosso 
Recently,new findings have been clarified concerning both pathogenesis and treatment of IgA nephritis.The four hits theory has been confirmed but several genetic wide association studies have allowed finding several g...
关键词：IgA nephropathy Anti IgA autoantibodies Genetic wide association studies Microbiota Anti B cell-activating factor agents Anti A proliferation-inducing ligand agents Anti complement agents 
Complement C1q induces the M2-polarization of tumor-associated macrophages in lung adenocarcinoma
《Genes & Diseases》2024年第4期145-148,共4页Yuxiao Song Yang Fu Jun Wang Jiazhuo Tang Jiaxin Yin Zhimin Zhang Qibin Song Bicheng Zhang 
funded by the National Natural Science Foundation of China(No.82272928);CSCO(Chinese Society of Clinical Oncology)-BMS(Bristol-Myers Squibb)Cancer Immunotherapy Research Foundation(No.Y-BMS2019-003);the Knowledge Innovation Program of Wuhan-Basic Research(China)(No.2022020801010475).
Complement C1q was proved to be able to regulate the polarization of macrophages to the anti-inflammatory phenotype(M2 polarized),acting as an anti-inflammation molecule independent of the classical complement pathway...
关键词：C1Q LUNG INFLAMMATION 
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