INTERLEUKIN-1

作品数：157被引量：855H指数：16
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相关机构：安徽医科大学长春中医学院横滨市立大学首都医科大学更多>>
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Emerging interleukin-1 receptor-associated kinase 4(IRAK4)inhibitors or degraders as therapeutic agents for autoimmune diseases and cancer
《Acta Pharmaceutica Sinica B》2024年第12期5091-5105,共15页Yifan Feng Chengjuan Chen Anqi Shao Lei Wu Haiyu Hu Tiantai Zhang 
supported by the National Natural Science Foundation of China(82293684 and 82293680);the National Key R&D Program of China(2020YFA0908004);CAMS Innovation Fund for Medical Science of China(2022-I2M-1-014).
Interleukin-1 receptor-related kinase(IRAK4)is a widely expressed serine/threonine kinase involved in the regulation of innate immunity.IRAK4 plays a pivotal role as a key kinase within the downstream signaling pathwa...
关键词：IRAK4 IL-1R/TLRs signal pathway NF-kB Autoimmune diseases IRAK4 inhibitors Degraders CANCER 
Single-cell analysis of tumor microenvironment and cell adhesion reveals that interleukin-1 beta promotes cancer cell proliferation in breast cancer被引量：1
《Animal Models and Experimental Medicine》2024年第5期617-625,共9页Wenyan Wang Gehong Dong Ziguo Yang Shaoxiang Li Jia Li Lin Wang Qiang Zhu Yuchen Wang 
funded by Young Elite Scientists Sponsorship Program by Beijing Association for science and technology(Grant No.BYESS2023226)。
Background: Triple-negative breast cancer(TNBC), which is so called because of the lack of estrogen receptors(ER), progesterone receptors(PR), and human epidermal growth factor receptor 2(HER2) receptors on the cancer...
关键词：biomaterial breast cancer IL1B plasma cells scRNA-seq 
Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy
《Military Medical Research》2024年第5期794-796,共3页Stanislovas S.Jankauskas Fahimeh Varzideh Pasquale Mone Urna Kansakar Francesco Di Lorenzo Angela Lombardi Gaetano Santulli 
National Institutes of Health(NIH):National Heart,Lung,and Blood Institute(NHLBI:R01-HL164772,R01-HL159062,R01-HL146691,T32-HL144456);National Institute of Diabetes and Digestive and Kidney Diseases(NIDDK:R01-DK123259,R01-DK033823);National Center for Advancing Translational Sciences(NCATS:UL1-TR002556-06,UM1-TR004400)(to Gaetano Santulli);Diabetes Action Research and Education Foundation(to Gaetano Santulli);Monique Weill-Caulier and Irma T.Hirschl Trusts(to Gaetano Santulli).
Diabetic cardiomyopathy is a disorder of the cardiac muscle that affects patients with diabetes.The exact mechanisms underlying diabetic cardiomyopathy are mostly unknown,but several factors have been implicated in th...
关键词：Adipsin Complement factor D INTERLEUKIN-1 Interleukin-1 receptor-associated kinase like 2(Irak2) Opa1 Prohibitin(PHB) 
Small extracellular vesicles from hypoxia-preconditioned bone marrow mesenchymal stem cells attenuate spinal cord injury via miR-146a-5p-mediated regulation of macrophage polarization被引量：1
《Neural Regeneration Research》2024年第10期2259-2269,共11页Zeyan Liang Zhelun Yang Haishu Xie Jian Rao Xiongjie Xu Yike Lin Chunhua Wang Chunmei Chen 
supported by the Fujian Minimally Invasive Medical Center Foundation,No.2128100514(to CC,CW,HX);the Natural Science Foundation of Fujian Province,No.2023J01640(to CC,CW,ZL,HX)。
Spinal cord injury is a disabling condition with limited treatment options.Multiple studies have provided evidence suggesting that small extracellular vesicles(SEVs)secreted by bone marrow mesenchymal stem cells(MSCs)...
关键词：bone marrow mesenchymal stem cells hypoxia preconditioning interleukin-1 receptor-associated kinase 1 MACROPHAGES mesenchymal stem cells small extracellular vesicles spinal cord injury 
Conservative management of spinal pathology with autologous conditioned serum: A systematic review of the literature
《World Journal of Orthopedics》2024年第9期870-881,共12页Christian J Rajkovic Matthew L Merckling Alyssa W Lee Galadu Subah Aryan Malhotra Zachary D Thomas Sabrina L Zeller John V Wainwright Merritt D Kinon 
BACKGROUND Chronic inflammatory pain is associated with increased expression of interleukin(IL)-1,an inflammatory cytokine,and activity on its receptor(IL-1R).In response,the body produces IL-1R antagonist(IL-1Ra)to r...
关键词：SPINE Autologous conditioned serum Orthokine Regenokine Epidural steroid injection INTERLEUKIN-1 Inter-leukin-1 receptor antagonist 
Systemic juvenile idiopathic arthritis–associated lung disease: A retrospective cohort study
《World Journal of Clinical Pediatrics》2024年第1期73-83,共11页Konstantin E Belozerov Natalia M Solomatina Eugenia A Isupova Alla A Kuznetsova Mikhail M Kostik 
Supported by the Ministry of Science and Higher Education of the Russian Federation,No.075-15-2022-301.
BACKGROUND Lung damage in systemic juvenile arthritis(sJIA)is one of the contemporary topics in pediatric rheumatology.Several previous studies showed the severe course and fatal outcomes in some patients.The informat...
关键词：Systemic juvenile arthritis Interstitial lung disease CANAKINUMAB TOCILIZUMAB INTERLEUKIN-6 INTERLEUKIN-1 
The role of Interleukin-1 family in cardiovascular disease and its research progress
《Journal of Hainan Medical University》2023年第17期57-62,共6页Lin Heng-xiu Zhang Yuan-yuan Zhang Bin-yue Wu Yue-wei Li Tian-fa 
Key Research and Development Project of Hainan Province(No.ZDYF2021SHFZ089);Rapid Innovation Foundation for Key Laboratories of the Ministry of Education(No.KLET-202019)。
The interleukin-1 family is a group of important cytokines that play a key regulatory role in the immune and inflammatory response(including infectious and non-bacterial injuries).Nowadays,the interleukin-1 family mai...
关键词：Interleukin-1 family Cardiovascular diseases INFLAMMATION Target therapy 
Interleukin-1:an important target for perinatal neuroprotection?
《Neural Regeneration Research》2023年第1期47-50,共4页Sharmony B.Kelly Elys Green Rod W.Hunt Claudia A.Nold-Petry Alistair J.Gunn Marcel F.Nold Robert Galinsky 
supported by the CJ Martin Postdoctoral Fellowship;grants from the National Health and Medical Research Council of Australia (1090890 and 1164954);the Cerebral Palsy Alliance, Harold and Cora Brennen Benevolent Trust, Health Research Council of New Zealand (17/601);the Victorian Government’s Operational Infrastructure Support Program (to RG)
Perinatal inflammation is a significant risk factor for lifelong neurodevelopmental impairments such as cerebral palsy.Extensive clinical and preclinical evidence links the severity and pattern of perinatal inflammati...
关键词：brain INFLAMMATION interleukin-1 receptor antagonist INTERLEUKIN-1 INTERLEUKIN-1Β neonatal encephalopathy NEUROPROTECTION preterm brain injury 
Efficacy of Sishen Wan(四神丸) on dinitrobenzene sulfonic acid-induced ulcerative colitis and its effect on toll-like receptor 2/interleukin-1 receptor-associated kinase-4/nuclear factor-κB signal pathway被引量：8
《Journal of Traditional Chinese Medicine》2022年第4期565-575,共11页ZHANG Zhaohua LIU Rong DU Nana ZHU Xiangdong 
Supported by the National Natural Science Foundation of China:to Explore the Immune Mechanism of Treating Ulcerative Colitis by Regulating Treg/Th17 Cell Imbalance by Warming the Kidney and Invigorating the Spleen through Intestinal Flora(No.81960826)
OBJECTIVE:To investigate the therapeutic effect of Sishen Wan(四神丸,SSW)on ulcerative colitis(UC)induced by dinitrobenzene sulfonic acid and its effect on toll-like receptor 2/interleukin-1 receptor-associated kinase...
关键词：colitis ulcerative toll-like receptor 2 interleukin-1 receptor-associated kinases NF-kappa B signal transduction therapeutic uses Sishen Wan 
Schnitzler syndrome and Schnitzler-like syndromes
《Chinese Medical Journal》2022年第10期1190-1202,共13页Cong-Qiu Chu 
Dr. Chu’s work was supported by the Innovative Award from the American College of Rheumatology Research Foundation and the VA Merit Review grant(No. I01BX005195)。
Schnitzler syndrome is a rare disease of adult-onset with main features including chronic urticarial rash, recurrent fever, arthralgia or arthritis, monoclonal gammopathy of undetermined significance (MGUS), and marke...
关键词：Schnitzler syndrome Schnitzler syndrome-like conditions INTERLEUKIN-1 Chronic urticarial rash 
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