Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy  

作　　者：Stanislovas S.Jankauskas Fahimeh Varzideh Pasquale Mone Urna Kansakar Francesco Di Lorenzo Angela Lombardi Gaetano Santulli 

机构地区：[1]Department of Medicine,Fleischer Institute for Diabetes and Metabolism(FIDAM),Einstein-Mount Sinai Diabetes Research Center(ES-DRC),Einstein Institute for Aging Research,Albert Einstein College of Medicine,New York,NY,10461,USA [2]Department of Molecular Pharmacology,Division of Cardiology,Wilf Family Cardiovascular Research Institute,Albert Einstein College of Medicine,New York,NY,10461,USA

出　　处：《Military Medical Research》2024年第5期794-796,共3页军事医学研究（英文版）

基　　金：National Institutes of Health(NIH):National Heart,Lung,and Blood Institute(NHLBI:R01-HL164772,R01-HL159062,R01-HL146691,T32-HL144456);National Institute of Diabetes and Digestive and Kidney Diseases(NIDDK:R01-DK123259,R01-DK033823);National Center for Advancing Translational Sciences(NCATS:UL1-TR002556-06,UM1-TR004400)(to Gaetano Santulli);Diabetes Action Research and Education Foundation(to Gaetano Santulli);Monique Weill-Caulier and Irma T.Hirschl Trusts(to Gaetano Santulli).

摘　　要：Diabetic cardiomyopathy is a disorder of the cardiac muscle that affects patients with diabetes.The exact mechanisms underlying diabetic cardiomyopathy are mostly unknown,but several factors have been implicated in the pathogenesis of the disease and its progression towards heart failure,including endothelial dysfunction,autonomic neuropathy,metabolic alterations,oxidative stress,and alterations in ion homeostasis,especially calcium transients[1].In Military Medical Research,Jiang et al.[2]sought to determine the functional role of complement factor D(Adipsin)in the pathophysiology of diabetic cardiomyopathy.

关 键 词：Adipsin Complement factor D INTERLEUKIN-1 Interleukin-1 receptor-associated kinase like 2(Irak2) Opa1 Prohibitin(PHB) 

分 类 号：R587.2[医药卫生—内分泌] R542.2[医药卫生—内科学]