Complement C1q induces the M2-polarization of tumor-associated macrophages in lung adenocarcinoma  

作　　者：Yuxiao Song Yang Fu Jun Wang Jiazhuo Tang Jiaxin Yin Zhimin Zhang Qibin Song Bicheng Zhang 

机构地区：[1]Cancer Center,Renmin Hospital of Wuhan University,Wuhan,Hubei 430061,China [2]Department of Oncology,Xiangyang Hospital,Hubei University of Chinese Medicine,Xiangyang,Hubei 441100,China [3]Department of Oncology,The First Affiliated Hospital of Shandong First Medical University,Jinan,Shandong 250000,China

出　　处：《Genes & Diseases》2024年第4期145-148,共4页基因与疾病（英文）

基　　金：funded by the National Natural Science Foundation of China(No.82272928);CSCO(Chinese Society of Clinical Oncology)-BMS(Bristol-Myers Squibb)Cancer Immunotherapy Research Foundation(No.Y-BMS2019-003);the Knowledge Innovation Program of Wuhan-Basic Research(China)(No.2022020801010475).

摘　　要：Complement C1q was proved to be able to regulate the polarization of macrophages to the anti-inflammatory phenotype(M2 polarized),acting as an anti-inflammation molecule independent of the classical complement pathway.A high level of C1q expression has been detected in the tumor microenvironment(TME)of diverse tumors,including non-small cell lung cancer,in which C1q could be considered a predictor of poor prognosis.

关 键 词：C1Q LUNG INFLAMMATION 

分 类 号：R734.2[医药卫生—肿瘤]